GEO DataSets

(Submitter supplied) We performed a whole-transcriptome analysis of the peripheral blood of untreated patients with stage 1 PD (Hoehn–Yahr scale).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5646

Platform:

GPL10558

10 Samples

Download data: TXT

Analysis of peripheral blood of untreated patients with stage 1 Parkinson's disease (PD), according to the Hoehn-Yahr scale, and paired healthy, age- and sex-matched controls. Results provide insight into molecular mechanisms underlying the initiation of the development of PD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL10558

Series:

GSE54536

10 Samples

Download data

(Submitter supplied) To get insight into systemic molecular events associated with Parkinson's disease (PD), an age-related neurodegenerative disorder, we compared gene expression patterns of peripheral blood mononuclear cells (PBMC) derived from elderly healhy controls and from PD patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

50 Samples

Download data: TXT

(Submitter supplied) Peripheral blood was collected from 18 Parkinson's Disease (PD) patients and 12 healthy controls (Ctrls). Total RNA was isolated and hybridized onto Affymetrix Exon_ST1 arrays to find in PDs versus controls: 1) genes that are differentiallly expressed and 2) genes with differential exonic expression (alternative splicing).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

28 Samples

Download data: CEL, TXT

(Submitter supplied) LRRK2 mutations are the most common genetic cause of Parkinson’s disease (PD). We performed a whole-genome RNA profiling of locus coeruleus post-mortem tissue from idiopathic PD (IPD) and LRRK2-associated PD patients. The differentially expressed genes found in IPD and LRRK2-associated PD were involved in the gene ontology terms of synaptic transmission and neuron projection. In addition, in the IPD group we found associated genes belonging to the immune system. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

10 Samples

Download data: CEL

(Submitter supplied) The given data set is the first deep sequencing transcriptome-wide data set of human Parkinson's disease (PD) patients RNA. The data set was produced from blood leukocytes of PD patients, from the same patients following deep brain stimulation (DBS), and from matched healthy control volunteers. Post-DBS samples were taken from the patients while being on electrical stimulation (ON-Stim), and following one hour off of electrical stimulation (OFF-Stim state). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9442

13 Samples

Download data: BED, GFF3, TAB, TXT

(Submitter supplied) Sub-thalamic deep brain stimulation (DBS) reversibly modulates Parkinson’s disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we report rapid stimulus-induced and largely reversible changes in PD leukocyte transcripts, which were larger in scope than the disease-induced changes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5188

27 Samples

Download data: CEL

(Submitter supplied) PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the first drugs used for symptomatic treatment of PD. Of note, MPTP intoxication is a model of choice for symptomatic neuroprotective therapies since it have been quite predictive. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4157

Platform:

GPL8321

29 Samples

Download data: CEL

Analysis of caudate-putamen and pre-frontal cortex from transgenics, over-expressing either risk-associated synaptic acetylcholinesterase (AChE)-S variant or the protective soluble AChE-R variant, exposed to environmental risk factor MPTP. Results provide insights into the molecular basis of PD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 genotype/variation, 2 tissue sets

Platform:

GPL8321

Series:

GSE31458

29 Samples

Download data: CEL

(Submitter supplied) Importance. Biological markers of Parkinson’s disease are essential for achieving disease modification. Objective. To determine the association of SNCA blood transcript levels with prevalence of Parkinson’s disease. Background. The SNCA locus is preferentially transcribed in neurons and blood cells. Non-coding genetic variants and neuronal aggregates of α-synuclein protein associate this locus with sporadic Parkinson’s disease and suggest a potential role for abnormal SNCA transcription in the disease mechanism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

142 Samples

Download data: TXT

(Submitter supplied) Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

93 Samples

Download data: CEL, CHP

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

29 Samples

Download data: CEL, CHP

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

35 Samples

Download data: CEL, CHP

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

29 Samples

Download data: CEL, CHP

(Submitter supplied) To investigate the role of miRNAs in the etiology of idiopathic PD, we conducted global miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of PD patients and controls.

Organism:

Rattus norvegicus; JC polyomavirus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Homo sapiens; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

32 Samples

Download data: TXT

(Submitter supplied) We performed transcriptional profiling to test the hypothesis that type I grouping severity in Parksino's disease link to distinct gene expression networks

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

36 Samples

Download data: TXT