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Links from GEO DataSets

Items: 18

1.

Genome-wide changes in gene expression during the development and after recovery from heart failure in a mouse model of transient cardiomyopathy.

(Submitter supplied) Altered myocardial gene expression from heart failure (HF) has mostly been identified by single-point analysis of end-stage disease. This may miss earlier changes in gene expression that are transient and/or directionally opposite to those observed later. By sampling left ventricular myocardial tissue at different time points in a mouse model of cardiomyopathy, we examined differentially expressed transcripts between non-failing controls, early-HF (2 and 3 days after cardiac insult), peak-HF (10 days) and after recovery from HF (28 days). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5469
Platform:
GPL6885
19 Samples
Download data: TXT
Series
Accession:
GSE54681
ID:
200054681
2.
Full record GDS5469

Left ventricle myocardium from MerCreMer model of transient cardiomyopathy: time course

Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets
Platform:
GPL6885
Series:
GSE54681
19 Samples
Download data
3.

Progression of heart failure induced by tachycardia

(Submitter supplied) Analysis of changes of gene expression profiles in the left ventricle (LV) during the progression of heart failure (HF) in the canine tachypacing induced HF model. Gene expression profiling was performed on samples collected at different time points representing various stages of LV dysfunction, i.e. tachypaced for 3 days (Day-3), 1 week (Week-1), 2 weeks (Week-2), 3-4 weeks (End stage), and unpaced controls (Day-0). more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3979
45 Samples
Download data: CEL, CHP
Series
Accession:
GSE9794
ID:
200009794
4.

Expression data during plantaris muscle hypertrophy induced by synergist ablation in young adult mice

(Submitter supplied) Global gene expression patterns were determined from microarray results on day 1, 3, 5, 7, 10 and 14 during plantaris muscle hypertrophy induced by synergist ablation in young adult mice (5 months).
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4932
Platform:
GPL6246
14 Samples
Download data: CEL
Series
Accession:
GSE47098
ID:
200047098
5.
Full record GDS4932

Synergist ablation effect on young adult plantaris muscle: time course

Analysis of right and left plantaris muscle from young males (5 months old) subjected to 1, 3, 5, 7, 10 and 14 days of synergist ablation surgery to induce hypertrophy. Results provide insight into the molecular response of young skeletal muscle to mechanical overload induced by synergist ablation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 stress, 7 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE47098
14 Samples
Download data: CEL
6.

Gene expression microarray profiling in mice hearts with pathological and physiological cardiac hypertrophy

(Submitter supplied) Compelling evidence suggests that mitochondrial dysfunction contributes to the pathogenesis of heart failure, including defects in the substrate oxidation, and the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS). However, whether such changes occur early in the development of heart failure, and are potentially involved in the pathologic events that lead to cardiac dysfunction is unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
30 Samples
Download data: CEL
Series
Accession:
GSE56348
ID:
200056348
7.

Gene expression profiles of rat enamel organs (secretory--stage and maturation stage)

(Submitter supplied) We conducted the genome-wide mRNA expression profiling in parallel with miRNA expression profiling using RNA samples extracted from rat incisor enamel organs, so as to refine the number of predicted gene targets for miRNA regulators.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
8 Samples
Download data: TXT
Series
Accession:
GSE59401
ID:
200059401
8.

Molecular alterations following myocardial infarction in mice

(Submitter supplied) Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. To address this issue, we have performed microarray analysis of non-infarcted left ventricular tissue from mice at various time-points after myocardial infarction. Methods: Molecular alterations in myocardial tissue were measured 3, 5, 7 and 14 days after induced infarction by using cDNA microarrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3386
Platform:
GPL891
20 Samples
Download data
Series
Accession:
GSE6580
ID:
200006580
9.
Full record GDS3386

Heart failure progression model: non-infarcted ventricular tissue

Analysis of non-infarcted left ventricular tissues from animals at various time points up to 14 days following myocardial infarction (MI). MI induced by ligating the left coronary artery. Results provide insight into the molecular pathogenesis of heart failure.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 time sets
Platform:
GPL891
Series:
GSE6580
20 Samples
Download data
DataSet
Accession:
GDS3386
ID:
3386
10.

Gene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support

(Submitter supplied) Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are available for the transcriptome regulation during non-pulsatile VAD-support. Therefore we analysed the gene-expression patterns of 30 paired samples from VAD-supported (including 8 non-pulsatile VADs) and 8 non-failing control hearts (NF) using the first total human genome-array available. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
68 Samples
Download data: CEL, TXT
Series
Accession:
GSE21610
ID:
200021610
11.

Genome-wide analysis of p53 binding by ChIP-seq

(Submitter supplied) We used ChIP-seq to identify the genomic locations bound by p53 in mouse kidney
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
2 Samples
Download data: BED
Series
Accession:
GSE49916
ID:
200049916
12.

Gene expression of p53 null vs. p53 wild-type mouse kidneys at embryonic day 15.5

(Submitter supplied) Gene expression microarray analysis was performed on E15.5 p53+/+ and p53-/- litter-matched kidneys. We have previously shown that p53 is expressed in both UB and MM lineages in the kidney, and that p53-null embryos on C57B6L background exhibit a range of congenital abnormalities of the kidney and urinary tract such as duplicated ureters, reduced nephron numbers, and compromised nephron progenitor renewal and differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
8 Samples
Download data: TXT
Series
Accession:
GSE49878
ID:
200049878
13.

Human ischemic cardiomyopathy, idiopathic cardiomyopathy, and nonfailing controls

(Submitter supplied) Left ventricular myocardium was snap-frozen at time of cardiac transplantation from patients with advanced idiopathic or ischemic cardiomyopathy, or at time of harvest from unused donor heart that serve as a nonfailing control. No subjects received mechanical support devices. Keywords: disease state analysis (case:control)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
210 Samples
Download data
Series
Accession:
GSE5406
ID:
200005406
14.

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
60 Samples
Download data: CEL, WIG
Series
Accession:
GSE48112
ID:
200048112
15.

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [NRVM Expression]

(Submitter supplied) Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylation, the role of epigenetic reader proteins in cardiac biology is unknown. We therefore undertook a first study of acetyl-lysine reader proteins, or bromodomains, in HF. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
20 Samples
Download data: CEL
Series
Accession:
GSE48111
ID:
200048111
16.

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [Mouse Heart Expression]

(Submitter supplied) Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylation, the role of epigenetic reader proteins in cardiac biology is unknown. We therefore undertook a first study of acetyl-lysine reader proteins, or bromodomains, in HF. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
27 Samples
Download data: CEL
Series
Accession:
GSE48110
ID:
200048110
17.

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [ChIP-Seq]

(Submitter supplied) Heart failure is driven by the interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. Coordinate activation of developmental, inflammatory, fibrotic and growth regulators underlies the hallmark phenotypes of pathologic cardiac hypertrophy and contractile failure. While transactivation in this context is known to be associated with recruitment of histone acetyl-transferase enzymes and local chromatin hyperacetylation, the role of epigenetic reader proteins in cardiac biology is unknown. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL9250
13 Samples
Download data: WIG
Series
Accession:
GSE46668
ID:
200046668
18.

RNA-sequencing of healthy human skeletal myocytes

(Submitter supplied) Skeletal myocytes are metabolically active and susceptible to insulin resistance, thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes and their elucidation at the systems level requires genome-wide data and biological networks. Genome-scale metabolic models (GEMs) provide a network-context to integrate high-throughput data. We generated myocyte-specific RNA-seq data and investigated their correlation with proteome data. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE63887
ID:
200063887
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