Similar studies for GEO DataSets (Select 200054798) - GEO DataSets

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE54799

ID:: 200054799

Select item 2000547974.

Long non-coding RNAs and mRNAs regulated by TGF-β

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB promotes the invasion-metastasis cascade, which suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for anti-metastatic therapies.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platform:: GPL15314
6 Samples

Download data: TXT

Series

Accession:: GSE54797

ID:: 200054797

Select item 2000470115.

Human breast cancer SKBr-3 cells: trastuzumab-resistant vs. parental

(Submitter supplied) Human breast cancer SKBr-3 cells selected with trastuzumab for 6 month compared with parental SKBr-3 cells; Goal was to screen for microRNAs involved in development of trastuzumab resistance.

Organism:: Merkel cell polyomavirus; Rattus norvegicus; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Mus musculus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8

Type:: Non-coding RNA profiling by array

Platform:: GPL11434
6 Samples

Download data: GPR

Series

Accession:: GSE47011

ID:: 200047011

Select item 2000861606.

Cancer associated-mesenchymal stem cells accelerate hepatocellular carcinoma progression though lncRNA-MUF-miR-34a-Snail1 axis

(Submitter supplied) Recently, long noncoding RNAs (lncRNAs) have been implicated in diverse processes of hepatocarcinogenesis. However, the involvement of lncRNAs in the crosstalk between LC-MSCs microenvironment and HCC progression is still unknown. In this study, for the first time, we investigated the role of lncRNAs in the crosstalk between HCC cells and LC-MSCs. We found that LC-MSCs acted as a pivotal contributor to HCC metastasis, cancer stem cell maintenance and epithelial-mesenchymal transition (EMT).

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL19072
6 Samples

Download data: TXT

Series

Accession:: GSE86160

ID:: 200086160

Select item 2000954237.

lncRNA expression of CRC liver metastasis

(Submitter supplied) The purpose of this study is to identify lncRNAs involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms. A total of 439 miRNAs were identified to be differentially expressed between 7 primary CRC tissues with liver metastases and 8 CRC tissues without liver metastases from 15 patients by Arraystar lncRNA microarrays

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16956
15 Samples

Download data: TXT

Series

Accession:: GSE95423

ID:: 200095423

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001511118.

The lncRNA expression profiles in hepatocellular carcinoma cell lines under sulfatide treatment

(Submitter supplied) Sulfatide significantly promoted hepatocellular carcinoma cells survival, proliferation and angiogenesis. To understand the molecular mechanisms of sulfatide, the transcriptional profiles of lncRNAs in human hepatocellular carcinoma cells SMMC-7721 was investigated with ArrayStar lncRNA microarray with sulfatide treatment. Galactose-cerebroside treatment served as the control.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15314
6 Samples

Download data: XLSX

Series

Accession:: GSE151111

ID:: 200151111

PubMed Full text in PMC Similar studies

Select item 2000355119.

Gene-expression profiling of ZNF217-overexpressing MDA-MB-231 cells

(Submitter supplied) To obtain an overview of the cellular functions regulated by ZNF217 signaling in breast-cancer cell lines, we performed global gene-expression profiling on MDA-MB-231-pcDNA6 and MDA-MB-231-ZNF217 cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4885
Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE35511

ID:: 200035511

Select item 488510.

Kruppel-like zinc finger protein ZNF217 overexpression effect on breast cancer cell line

Analysis of MDA-MB-231 cells overexpressing ZNF217. ZNF217 is a Kruppel-like zinc finger protein that localizes to the nucleus. Results provide insight into the role of ZNF217 in the progression of breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL570
Series:: GSE35511
4 Samples

Download data: CEL

DataSet

Accession:: GDS4885

ID:: 4885

Select item 20006726011.

Invasion and metastasis related long non-coding RNA expression profiles in hepatocellular carcinoma

(Submitter supplied) Aberrant expression of LncRNAs might be responsible for the HCC invasion and metastasis. we employed the LncRNAs microarray technology to study the LncRNAs expression profiles at genome-wide in hepatocellular carcinoma (HCC)tissue samples with early recurrence (less than 1 year, with invasion and metastasis out of liver) and late recurrence (longer than 2 years, without invasion and metastasis out of liver), which had different recurrent/metastatic potentials, by using normal liver tissue as control to screen the dysregulated LncRNAs which are potentially involved in the recurrence, invasion and metastasis process of HCC

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL19072
15 Samples

Download data: TXT

Series

Accession:: GSE67260

ID:: 200067260

Select item 20009935112.

Long noncoding RNA expression profiles in sub-lethal heat treated hepatoma carcinoma cells. (SMMC-7721 cells: sub-lethal heat treated vs. untreated)

(Submitter supplied) Transcriptional profiling of SMMC-7721 cells comparing control untreated with sub-lethal heat treated cells (50°C for 10 min). Differentially expressed lncRNA and mRNA were measured with an Agilent Human lncRNA+mRNA Array V4.0 (4 × 180 K format) containing 41,000 lncRNAs and 34,000 mRNAs. Goal was to determine the effects of sub-lethal heat treatment on global hepatoma carcinoma cells gene expression.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20115
6 Samples

Download data: TXT

Series

Accession:: GSE99351

ID:: 200099351

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011165513.

The LINC01138 Drives Malignancies via Activating Arginine Methyltransferase 5 in Hepatocellular Carcinoma

(Submitter supplied) Our study have demonstrated LINC01138 acts as an oncogenic driver that promotes cell proliferation, tumourigenicity, tumour invasion and metastasis through physically interacting with Arginine Methyltransferase 5 (PRMT5) in HCC cells. In order to investigate the related signaling pathways regulated by LINC01138 or PRMT5, we performed the unbiased transcriptome profiling using high-throughput RNA sequencing in SMMC-7721 cells transfected with si-LINC01138 or si-PRMT5. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE111655

ID:: 200111655

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008576614.

Cellular model of colon cancer progression reveals signatures of mRNAs, miRNA, lncRNAs and epigenetic modifications associated with metastasis.

(Submitter supplied) H3K4me3, H3K27me3, and H3K79me3 profiling of a cellular model of colorectal cancer progression, which is based on four defined derivates of a CRC cell line that resulted from EMT/MET transitions and phenotypically recapitulate the metastatic cascade: epithelial-like primary tumor, mesenchymal-like tumor cells growing in soft agar or as colonospheres, and mouse xenografts of the latter resulting in lung-metastasis comprised of epithelial-state cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE85766

ID:: 200085766

PubMed Similar studies SRA Run Selector

Select item 20008568815.

Cellular model of colon cancer progression reveals signatures of mRNAs, miRNA, lncRNAs and epigenetic modifications associated with metastasis.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array; Non-coding RNA profiling by array

Platforms:: GPL21576 GPL13534 GPL16791
18 Samples

Download data: IDAT, TXT

Series

Accession:: GSE85688

ID:: 200085688

Select item 20008568716.

microRNA profiling of four DLD1 colorectal cancer cell derivatives that recapitulate EMT/MET transitions during metastasis.

(Submitter supplied) microRNA profiling of a cellular model of colorectal cancer progression, which is based on four defined derivates of a CRC cell line that resulted from EMT/MET transitions and phenotypically recapitulate the metastatic cascade: epithelial-like primary tumor, mesenchymal-like tumor cells growing in soft agar or as colonospheres, and mouse xenografts of the latter resulting in lung-metastasis comprised of epithelial-state cells.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21576
10 Samples

Download data: TXT

Series

Accession:: GSE85687

ID:: 200085687

Select item 20008568517.

RNA profiling of four DLD1 colorectal cancer cell derivatives that recapitulate EMT/MET transitions during metastasis.

(Submitter supplied) RNA profiling of a cellular model of colorectal cancer progression, which is based on four defined derivates of a CRC cell line that resulted from EMT/MET transitions and phenotypically recapitulate the metastatic cascade: epithelial-like primary tumor, mesenchymal-like tumor cells growing in soft agar or as colonospheres, and mouse xenografts of the latter resulting in lung-metastasis comprised of epithelial-state cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE85685

ID:: 200085685

Select item 20008552918.

DNA methylation profiling of four DLD1 colorectal cancer cell derivatives that recapitulate EMT/MET transitions during metastasis.

(Submitter supplied) DNA methylation profiling of four DLD1 colorectal cancer cell derivatives that recapitulate EMT/MET transitions during metastasis. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
4 Samples

Download data: IDAT

Series

Accession:: GSE85529

ID:: 200085529

Select item 20010112519.

RNA-Seq expression profiling of mouse DEN-initiated hepatocytes with or without Tgfbr2 inactivation

(Submitter supplied) Initiated hepatocytes (IHCs), isolated from DEN exposed Tgfbr2 flox/flox mouse, were infected with GFP or Cre-expressed adenovirus, followed by 1ng/ml TGFβ × 48 hours incubation. Then total RNAs were isolated and processed to routine sequencing on Illumina platform. RNA-Seq libraries were prepared from total RNA using polyA enrichment.