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Links from GEO DataSets

Items: 20

1.

Genome Wide Expression of Mammary Epithelial Populations in Slug (SNAI2) WT vs Slug Null Mice

(Submitter supplied) This experiment shows differential expression of genes in the luminal, basal and stromal subpopulations from SNAI2+/+ and SNAI2 LacZ/LacZ mammary epithelial cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
24 Samples
Download data: TXT
Series
Accession:
GSE55620
ID:
200055620
2.

Cell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10481 GPL17784
21 Samples
Download data
Series
Accession:
GSE54735
ID:
200054735
3.

Cell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Agilent microarray samples]

(Submitter supplied) Alterations that perturb differentiation and cell state transitions can lead to defects in development, function and the genesis of cancer. Studying cellular plasticity at high resolution and in real time has proven difficult using existing methods. Here, we use a quantitative approach to gain insights into cell state dynamics of normal mammary epithelial cells (MECs) and validate the model's predictions in vivo. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10481
18 Samples
Download data
Series
Accession:
GSE54713
ID:
200054713
4.

Cell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Nanostring nCounter samples]

(Submitter supplied) Gene expression data of MCF10A cell subpopulations: luminal, basal and luminal.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17784
3 Samples
Download data: TXT
Series
Accession:
GSE51397
ID:
200051397
5.

Gene expression profiles of young and aged mammary epithelial and stromal cell populations from Wild Type and Slug/Snai2-null mice

(Submitter supplied) This experiment shows RNA-Seq gene expression profiles of Wild Type and Slug/Snai2-null luminal, basal, and stromal mammary cell populations from young (3 mo) and aged (12 mo) mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
26 Samples
Download data: TXT
Series
Accession:
GSE132127
ID:
200132127
6.

Genome-wide maps of SNAI2 binding in undifferentiated and differentiated keratinocytes

(Submitter supplied) We report the ChIP-Seq results of SNAI2 in several different conditions which include: SNAI2 binding in both control and SNAI2 knockdown cells to demonstrate specificity of the binding. SNAI2 ChIP-Seq was also performed in SNAI2 or control LACZ overexpressing cells cultured in growth medium as well as LACZ or SNAI2 overexpressing cells in differentiation medium.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
18 Samples
Download data: TXT
Series
Accession:
GSE55421
ID:
200055421
7.

Gene expression data on human keratinocytes with knockdown or overexpression of SNAI2

(Submitter supplied) 1. Keratinocytes infected with retroviruses expressing control or SNAI2 shRNAs were cultured in growth medium and Affymetrix HG-U133 plus 2.0 arrays were used to determine global gene expression profiles. 2. Keratinocytes infected with retroviruses overexpressing LACZ or SNAI2 were cultured in growth medium and Affymetrix HG-U133 plus 2.0 arrays were used to determine global gene expression profiles.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE55269
ID:
200055269
8.

The transcription factors Snail and Slug activate the TGF-B signaling pathway in breast cancer

(Submitter supplied) Gene expression profiling to determine transcriptome changes following Snail or Slug expression in MCF-7 breast cancer cells Samples were isolated in three biological replicates for microarray analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE29672
ID:
200029672
9.

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
20 Samples
Download data: TXT
Series
Accession:
GSE47493
ID:
200047493
10.

Transcriptome profiles of mouse mammary stem cells and progenitor cells

(Submitter supplied) MaSC, Luminal progenitor enriched subpopulations were isolated from virgin and pregnant mice based on using both surface marker or internal reporter transgene (GFP) expression. (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the transcirptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
14 Samples
Download data: TXT
Series
Accession:
GSE47419
ID:
200047419
11.

∆Np63 regulates stem cell activity in mammary gland development

(Submitter supplied) MaSC, luminal progenitor enriched subpopulations and total MECs as well, were isolated from both wild type and ∆Np63 KO heterozygous mouse and the transcriptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE47417
ID:
200047417
12.

Gene expression analyses of C/EBPb knockout in stem/progenitor cell populations

(Submitter supplied) CCAAT/enhancer binding protein beta (C/EBPb) is a member of a family of highly conserved transcription factors that regulates numerous genes involved in proliferation and differentiation in a variety of tissues. C/EBPb is deregulated in human breast cancer and germline deletion of this gene results in multiple defects in mammary gland development. We hypothesized that C/EBPb regulates mammary stem cell self-renewal, maintenance and/or differentiation through the regulation of multiple target genes that coordinate mammary gland development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE16380
ID:
200016380
13.

mRNA and miRNA expression profiling in mouse bronchoalveolar stem cells (BASC)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Other
Platforms:
GPL1261 GPL11199
8 Samples
Download data: CEL
Series
Accession:
GSE30437
ID:
200030437
14.

MicroRNA expression profile in mouse bronchoalveolar stem cells (BASC)

(Submitter supplied) We performed miRNA and mRNA profiling in BASC cells and c-Myc depleted BASC cells. We built potential miRNA-mRNA interaction networks specific to c-Myc regulation in BASCs
Organism:
Mus musculus
Type:
Other
Platform:
GPL11199
4 Samples
Download data: TXT
Series
Accession:
GSE30435
ID:
200030435
15.

mRNA expression profiling in mouse bronchoalveolar stem cells (BASC)

(Submitter supplied) We performed miRNA and mRNA profiling in BASC cells and c-Myc depleted BASC cells. We built potential miRNA-mRNA interaction networks specific to c-Myc regulation in BASCs
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE30323
ID:
200030323
16.

Distinct EMT programs control normal stem cells and cancer stem cells of mammary tissue

(Submitter supplied) Cancer stem cells (CSCs) are proposed to be responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between CSCs and normal tissue stem cells (SC) has led to the notion that CSCs often co-opt the normal SC program of their tissue-of-origin. The cell-biological program termed epithelial-mesenchymal transition (EMT) has been found to encourage entrance of normal and neoplastic mammary cells into the corresponding SC states. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL17021
4 Samples
Download data: BED
Series
Accession:
GSE61198
ID:
200061198
17.

Early parity-induced gene expression in total mammary epithelial cells and mammary cell subtypes in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
43 Samples
Download data: CEL
Series
Accession:
GSE40877
ID:
200040877
18.

Early parity-induced gene expression in total mammary epithelial cells in mice

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profile of total isolated mammary epithelial cells in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE40876
ID:
200040876
19.

Early parity-induced gene expression in mouse mammary cell subtypes

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profiles of stromal and various epithelial mammary cell subpopulations in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
35 Samples
Download data: CEL
Series
Accession:
GSE40875
ID:
200040875
20.

Expression data from tumor and normal epithelium derived from BRCA1-mutation carriers

(Submitter supplied) Microarrays were used to determine relative global gene expression changes in WT and BRCA1-mutation carrier breast epithelium as well as tumors created from WT and BRCA1-mutation carrier breast epithelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3921
16 Samples
Download data: CEL
Series
Accession:
GSE25835
ID:
200025835
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