Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 17

1.

Gene Expression Analysis of 4T1 orthotopic tumors in PDGFRb-TK mice

(Submitter supplied) Analysis of the gene expression level of 4T1 orthotopic tumors in mice with and without pericyte depletion.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6887 GPL6885
13 Samples
Download data: TXT
Series
Accession:
GSE55785
ID:
200055785
2.

Imatinib Disrupts Lymphoma Angiogenesis by Targeting Vascular Pericytes

(Submitter supplied) Pericytes/vascular smooth muscle cells (VSMCs), regulated by platelet-derived growth factor receptor β (PDGFRβ) signaling, play important roles in endothelial survival and vascular stability. Here we report that treatment with imatinib, an inhibitor of PDGFRβ, led to significant tumor growth impairment associated with increased apoptosis in human lymphoma xenografts including Farage, Karpas422 and OCI-Ly7 in SCID mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7437
4 Samples
Download data: PAIR
Series
Accession:
GSE30752
ID:
200030752
3.

FACS-array profiling in retinal endothelial cells from living mouse retinas without pericyte coverage

(Submitter supplied) Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice treated with neutralizing antibody against PDGFRb (APB5) and performed gene expression profiling using DNA microarray. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL82 GPL83 GPL81
9 Samples
Download data: CEL
Series
Accession:
GSE86819
ID:
200086819
4.

FACS-array profiling in retinal endothelial cells from living mouse retinas

(Submitter supplied) Deregulated retinal angiogenesis directly cause vision loss in many ocular diseases, such as diabetic retinopathy and retinopathy of prematurity. To identify endothelial-specific genes expressed in angiogenic retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice and performed gene expression profiling using DNA microarray. To find out genes associated with angiogenesis, comparisons of microarray data were carried out between GFP-negative non-endothelial retinal cells and GFP-positive retinal endothelial cells in angiogenic P8 retina.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4461 GDS4462 GDS4463
Platforms:
GPL82 GPL81 GPL83
18 Samples
Download data: CEL
Series
Accession:
GSE27238
ID:
200027238
5.
Full record GDS4463

Endothelial cells from P8 neonatal retina [MG_U74Cv2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL83
Series:
GSE27238
6 Samples
Download data: CEL
6.
Full record GDS4462

Endothelial cells from P8 neonatal retina [MG_U74Bv2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL82
Series:
GSE27238
6 Samples
Download data: CEL
7.
Full record GDS4461

Endothelial cells from P8 neonatal retina [MG_U74Av2]

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL81
Series:
GSE27238
6 Samples
Download data: CEL
8.

Pericyte-fibroblast transition promotes tumor growth and metastasis

(Submitter supplied) Vascular pericytes, an important cellular component, in the tumor microenvironment, are often associated with tumor vasculatures and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte fibroblast transition (designated as PFT), which significantly contributes to tumor invasion and metastasis. Gain- and loss-of-function experiments demonstrate that the PDGF-BB-PDGFRβ signaling promotes PFT in vitro and in in vivo tumors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18535
9 Samples
Download data: CEL
Series
Accession:
GSE85955
ID:
200085955
9.

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.

(Submitter supplied) The platelet-derived growth factor (PDGF) signaling system contributes to tumor angiogenesis and vascular remodeling. Here, we show PDGF-BB markedly induces erythropoietin (EPO) mRNA and protein expression by targeting the PDGFR-beta+ stromal and perivascular compartments. In mouse tumor models, PDGF-BB-induced EPO promotes tumor growth via two mechanisms: 1) paracrine stimulation of tumor angiogenesis by directly inducing endothelial cell proliferation, migration, sprouting and tube formation; and 2) endocrine stimulation of extramedullary hematopoiesis leading to increased oxygen perfusion and protection against tumor-associated anemia. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7546
6 Samples
Download data: CEL
Series
Accession:
GSE33717
ID:
200033717
10.

RNAseq of B16F10 melanoma CD31+ cells

(Submitter supplied) Intravasation, vascular dissemination and metastasis of malignant tumor cells require their passage over the vascular wall which is commonly composed of pericytes (mural cells) and the endothelial cell barrier. We currently decided to investigate the relative contribution of these cell types for B16F10 melanoma metastasis in mice using an experimental model of Shb gene inactivation. RNAseq of tumor endothelial cells from these mice revealed changes in cellular components such as adherens junctions and focal adhesions by gene ontology analysis that were in line with the observed effects on leakage and junction morphology.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL17021
10 Samples
Download data: TXT
Series
Accession:
GSE145201
ID:
200145201
11.

Dose-dependent dual roles of PDGF-BB–PDGFR-β in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis

(Submitter supplied) Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, anti-PDGF drugs significantly inhibited tumor growth and metastasis by preventing pericyte (PC) loss and vascular permeability. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13730
6 Samples
Download data: CEL
Series
Accession:
GSE46564
ID:
200046564
12.

Hypoxia-responsive gene expression profile of U87 MG glioblastoma cells and their exosomes.

(Submitter supplied) How cancer cells adapt to hypoxia during tumor development remains an important question. The hypothesis tested in the present study was that tumor cell-derived exosome vesicles (also known as microvesicles or extracellular vesicles) are mediators of hypoxia-dependent intercellular signaling in glioblastoma (GBM), i.e. highly aggressive brain tumors characterized by hypoxia and a vascular density that is among the highest of all human malignancies. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
12 Samples
Download data: TXT
Series
Accession:
GSE45301
ID:
200045301
13.

Mesenchymal tumors can derive from pericytes.

(Submitter supplied) We demonstrated that deletion of the p53 tumor suppressor gene in NG2 expressing cells resulted in the development of bone and soft tissue sarcomas that closely resemble human tumors. To determine gene expression differences between NG2 expressing pericytes lacking p53 and sarcomas that arose from deletion of p53 in NG2 expressing cells, RNA sequencing analysis was implemented.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE63679
ID:
200063679
14.

Transcriptome analysis of a novel mouse model of osteosarcoma and soft tissue sarcoma

(Submitter supplied) Analysis of differential gene expression between mouse sarcoma and normal tissue
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE63631
ID:
200063631
15.

Expression data from control and Angpt2 silenced mouse melanoma cells

(Submitter supplied) The functional role of tumor cell-expressed Angpt2 still remains elusive. Here, we used mouse melanoma cells which have endgeneous Angpt2 expression and invesitgated the functional role of tumor cell-derived Angpt2. Total RNA from control and Angpt2 silenced mouse melanoma cells (RET) was isolated and was further utilized for microarray analysis using Affymetrix Mouse Gene 2.0 ST array.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE146320
ID:
200146320
16.

Genome-wide analysis of ex vivo gene expression of tumour pericytes and tumour endothelial cells obtained from 67NR mouse primary tumors

(Submitter supplied) Pericytes are integral components of the tissue vasculature and have essential functions in tumour angiogenesis. Endosialin (CD248) is a type I transmembrane glycoprotein highly expressed on pericytes in the tumour vasculature of most solid tumours, however it is low or negligibly expressed on normal tissue pericytes. Experiments using wild-type and endosialin-knockout mice has revealed that stromal endosialin expression facilitates intravasation of tumor cells from the primary tumor into the circulation, thereby promoting metastatic dissemination.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
16 Samples
Download data: TXT
Series
Accession:
GSE84008
ID:
200084008
17.

Analysis of NSL knockout brains

(Submitter supplied) In the current study, we analyse the function of MOF-NSL complex in neural cells. We find that the NSL complex regulates metabolic networks in the brain.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21493 GPL19057
85 Samples
Download data: BW, TSV, TXT
Series
Accession:
GSE138981
ID:
200138981
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_616e997945cdce0789da37ac|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center