GEO DataSets

(Submitter supplied) HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune respone and cell signaling pathways. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human macrophages infected with HIV-1 Vpr. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5294

Platform:

GPL570

4 Samples

Download data: CEL, TXT

Analysis of monocyte-derived macrophages infected with a recombinant adenovirus expressing the HIV-1 Vpr protein. HIV-1 Vpr is a multi-functional protein involved in HIV-1 replication and pathogenesis. Results provide further insight into the role of HIV-1 Vpr in HIV-1 infected macrophages.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 individual sets

Platform:

GPL570

Series:

GSE56591

4 Samples

Download data: CEL

(Submitter supplied) HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune responses. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human dendritic cells infected with HIV-1 Vpr. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

4 Samples

Download data: CEL

(Submitter supplied) Temporal changes of the expression levels of the complete human transcriptome during the first 24 hours following infection of IFN-pre-treated macrophages. This approach has allowed us to identify genes involved in the IFN signaling that have an impact on HIV-1 infection of macrophages KEYWORDS: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4232

Platform:

GPL570

17 Samples

Download data: CEL

Temporal analysis of macrophages pretreated for 18hrs with interferon alpha 2 (IFNα2) then infected with HIV-1 (Bal strain). IFN treatment prior to in vitro HIV infection inhibits virus replication. Results provide insight into molecular mechanisms underlying this modulation of viral replication.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 infection, 2 protocol, 6 time sets

Platform:

GPL570

Series:

GSE30536

17 Samples

Download data: CEL

(Submitter supplied) HIV is able to outpace the innate immune response, including the response mediated by interferon (IFN), to establish a productive infection. However, monocyte derived macrophages (MDMs) may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to modulate the type I IFN-mediated innate immune response when it encounters a cell that has already been exposed to IFN was investigated.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6884

24 Samples

Download data: IDAT, SDF, TXT

(Submitter supplied) HIV-1 Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon-stimulated genes (ISGs) in the absence of interferons (IFNs). We investigated the genome-wide Tat association with cellular promoters in immature dendritic cells (iDC) and in monocyte derived macrophages (MDM). Chromatin immunoprecipitation (ChIP) of Tat together with chromatin profiling by ChIP-on-chip analysis demonstrated that Tat associates with the MAP2K6 and MAP2K3 promoters and mediates its increase, which also affects the induction of some ISGs.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL8170 GPL8169

6 Samples

Download data: TXT

(Submitter supplied) Our work demonstrated that miR-183 cluster regulates IFN production and signaling We used microarrays to detail the effect of miR-183 cluster on hepatic gene expression during immunostimulation with poly(I:C). Our finding suggests enrichment of pathways involved in IFN production and signaling. Amoung the miR-183 repressed genes, we identifies PPP2CA and TRIM27, which are negative regulators of the innate immune response.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16686

4 Samples

Download data: CEL, CHP

(Submitter supplied) Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neuronal deregulation. The viral protein R (Vpr), a protein encoded by HIV-1, has been shown to alter the expression of various important cytokines and inflammatory proteins in infected and uninfected cells; however the mechanisms involved remain unclear. more...

Organism:

human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:

Expression profiling by array; Non-coding RNA profiling by array

4 related Platforms

28 Samples

Download data: CEL, GPR, TXT

(Submitter supplied) We sought to determine how gene expression changes during the first two years of HIV-1 infection among participants from HIV-1 serodiscordant couple cohorts from sub-Saharan Africa. This study included whole blood samples from 26 participants who did not have HIV-1 at study enrollment, had a steady sexual relationship with a partner with HIV-1 and acquired HIV-1 during follow-up. Most participants had samples from before and after infection.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

90 Samples

Download data: TXT