Similar studies for GEO DataSets (Select 200057132) - GEO DataSets

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Items: 20

Select item 2000571321.

Evaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL18609 GPL18615
120 Samples

Download data: CEL, GPR, TXT

Series

Accession:: GSE57132

ID:: 200057132

Select item 2000571292.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]

(Submitter supplied) The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18615
60 Samples

Download data: CEL

Series

Accession:: GSE57129

ID:: 200057129

Select item 2000570823.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]

(Submitter supplied) The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL18609
60 Samples

Download data: GPR, TXT

Series

Accession:: GSE57082

ID:: 200057082

Select item 2000720884.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL18615 GPL18609
340 Samples

Download data: CEL, GPR, TXT

Series

Accession:: GSE72088

ID:: 200072088

Select item 2000720815.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)

(Submitter supplied) The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has been proven successful in improving the prediction of genotoxicity in vivo and the understanding of underlying mechanisms. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18615
184 Samples

Download data: CEL

Series

Accession:: GSE72081

ID:: 200072081

Select item 2000720146.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)

Organism:: Homo sapiens; Rattus norvegicus; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL18609
156 Samples

Download data: GPR, TXT

Series

Accession:: GSE72014

ID:: 200072014

Select item 2000401177.

Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(Submitter supplied) For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared.

Organism:: Rattus norvegicus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL15933 GPL13916
548 Samples

Download data: CEL

Series

Accession:: GSE40117

ID:: 200040117

Select item 2000365248.

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

(Submitter supplied) At present, substantial efforts are focused on the development of in vitro assays coupled with ”omics” technologies for the identification of carcinogenic substances as an alternative to the classical 2-year rodent carcinogenicity bioassay. A prerequisite for the eventual regulatory acceptance of such assays, however, is the in vivo relevance of the observed in vitro findings.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
72 Samples

Download data: CEL

Series

Accession:: GSE36524

ID:: 200036524

Select item 2000438479.

MicroRNA and mRNA biomarkers for short-term in vivo genotoxic and non-genotoxic carcinogen classification

(Submitter supplied) Many innovative techniques and scientific improvements are available to tackle societal concerns, like public health safety and confining the risk of cancerous exposure to chemicals, but have not been thoroughly tested and implicated yet. We investigated if microRNA and mRNA transcription profiles can be implemented in a short-term carcinogen classifier assay. Our study is additionally focusing on the drawbacks of present-day carcinogen screening strategies and also aims to contribute to a more ethical approach towards animal use and welfare within risk assessment. more...

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL16560
68 Samples

Download data: TXT

Series

Accession:: GSE43847

ID:: 200043847

Select item 20002475110.

Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage

(Submitter supplied) Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in microRNA (miRNA) expression in adult mouse liver following oral gavage with BaP despite a robust transcriptome response. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL8824 GPL4134
45 Samples

Download data: TXT

Series

Accession:: GSE24751

ID:: 200024751

Select item 20003812411.

Characterization of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows a strong conservation of involved transcription factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL15592 GPL11084
30 Samples

Download data: CEL

Series

Accession:: GSE38124

ID:: 200038124

Select item 20003812312.

Expression Profiles of PMH treated with 7µM of the genotoxic compound cisplatin

(Submitter supplied) The transcriptomic changes induced in primary mouse hepatocytes (C57BL/6 ) by 7µM of cisplatin after treatment for 24 and 48h

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15592
12 Samples

Download data: CEL

Series

Accession:: GSE38123

ID:: 200038123

Select item 20003812213.

Expression Profiles of HepG2 cells treated with 7µM of the genotoxic compound cisplatin

(Submitter supplied) The transcriptomic changes induced in the human liver cell line HepG2 by 7µM of cisplatin after treatment for 12, 24 and 48h

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11084
18 Samples

Download data: CEL

Series

Accession:: GSE38122

ID:: 200038122

Select item 20007154914.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL18402 GPL16284 GPL17996
18 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE71549

ID:: 200071549

Select item 20007154815.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma [DNA methylation]

(Submitter supplied) Chronic exposure to aflatoxin B1 (AFB1) has, in certain regions in the world, been strongly associated with the development of hepatocellular carcinoma (HCC). AFB1 is a very potent hepatotoxic and carcinogenic mycotoxin which is frequently reported as a food contaminant. Epigenetic modifications provoked by environmental exposures, such as AFB1, may create a so called persistent "epigenetic memory" or "footprint". more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
6 Samples

Download data: PAIR, TXT

Series

Accession:: GSE71548

ID:: 200071548

PubMed Similar studies

Select item 20007154716.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma [mRNA]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17996
6 Samples

Download data: CEL

Series

Accession:: GSE71547

ID:: 200071547

Select item 20007154517.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma [miRNA]

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
6 Samples

Download data: TXT

Series

Accession:: GSE71545

ID:: 200071545

Select item 20006707818.

Aflatoxin B1 exposure induces epigenetic mechanisms in primary human hepatocytes revealing novel biological processes associated with hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL16284 GPL18402 GPL17996
31 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE67078

ID:: 200067078

Select item 20006700519.

Aflatoxin B1 exposure induces epigenetic mechanisms in primary human hepatocytes revealing novel biological processes associated with hepatocellular carcinoma (MeDIP)

(Submitter supplied) The study investigated differential gene expression, microRNA expression and DNA methylation changes in a pool of primary human hepatocyte RNA and DNA following 5 days of repetitive exposure to a low or moderate dose of aflatoxin B1 or DMSO. Three biological replicates per compound/solvent. In total 9 arrays.