Similar studies for GEO DataSets (Select 200058822) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000588221.

TMPRSS2 Influences Prostate Cancer Metastasis

(Submitter supplied) TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion of Tmprss2, we demonstrate that the activity of this protease regulates cancer cell invasion and metastasis to distant organs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4070
9 Samples

Download data: GPR

Series

Accession:: GSE58822

ID:: 200058822

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001421582.

Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin–mediated prostatic tumorigenesis

(Submitter supplied) Co-occurrence of aberrant hepatocyte growth factor (HGF)/MET proto-oncogene receptor tyrosine kinase (MET) and Wnt/β-catenin signaling pathways has been observed in advanced and metastatic prostate cancers. This co-occurrence positively correlates with prostate cancer progression and castration-resistant prostate cancer (CRPC) development. However, the biological consequences of these abnormalities in these disease processes remain largely unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE142158

ID:: 200142158

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000220103.

TMPRSS2:ERG promotes invasiveness and epithelial to mesenchymal transition in prostate cancer model

(Submitter supplied) Recently, a frequent chromosomal aberration fusing Androgen regulated TMPRSS2 promoter and the ERG gene (T/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between the T/ERG and other defective pathways in cancer progression however, the biological mechanism by which the T/ERG operates is yet to be determined. Using immortalized prostate epithelial cells (EP) model we were able to show that EP with the combination of androgen receptor(AR) and T/ERG(EP-AR T/ERG cell line) demonstrate an Epithelial to Mesenchymal Transition (EMT) manifested by a mesenchyme-like morphological appearance and behavior. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE22010

ID:: 200022010

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000610084.

Investigating gene expression changes in wildtype and TMPRSS2-ERG homozygous mouse prostate tissue

(Submitter supplied) A transgenic TMPRSS2:ERG mouse model was engineered in FVB background and compared to its wildtype counterpart in the absence of any treatment This experiment is designed to look at ERG-dependent changes in phenotype and gene expression

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE61008

ID:: 200061008

PubMed Similar studies SRA Run Selector

Select item 2000607715.

Testing gene expression changes in VCaP upon depletion of the mutated ETS transcription factor ERG

(Submitter supplied) VCaP cells expressing inducible shRNAs for either ERG or a non-targeting control were treated with Doxycycline for 1, 3, 7 and 10 days prior to collection This experiment is designed to see which genes and pathways are modulated by ERG knockdown

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL

Series

Accession:: GSE60771

ID:: 200060771

Select item 2000714046.

Expression array analysis of the hepatocyte growth factor (HGF) invasive program

(Submitter supplied) HGF stimulates mitogenesis, motogenesis and morphogenesis in most epithelial target cells. Selective inhibition of HGF signaling blocks spontaneous metastasis, but not primary tumor growth, in the prostate adenocarcinoma derived PC3M cell xenograft model. To identify the HGF activated genes and pathways that contribute to cell motility and invasion, i.e. the HGF invasive program, expression profiling was performed on PC3M cells that were untreated or were treated with human HGF (hHGF), which drives all 3 primary activities, or with human HGF/NK2 (hNK2) or murine HGF (mHGF), which drive motility and invasion but not proliferation in human cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
36 Samples

Download data: CEL

Series

Accession:: GSE71404

ID:: 200071404

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000630707.

Haploinsufficiency of interstitial genes between TMPRSS2 and ERG contributes to prostate tumorigenesis

(Submitter supplied) TMPRSS2-ERG gene fusions that are frequently identified in prostate cancer can be generated either through chromosomal translocation or via interstitial deletion. The latter mechanism deletes an interstitial region of ~3Mb and it remains largely unanswered whether genes deleted within this region contribute to prostate cancer. By characterizing two knockin mouse models recapitulating TMPRSS2-ERG fusions with or without the interstitial deletion, we found that only those with deletion developed poorly differentiated adenocarcinomas with epithelial-to-mesenchymal transition, when under a Pten-null background. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE63070

ID:: 200063070

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000323568.

AR binding in prostate cancer cell lines VCaP and VCS2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL570 GPL9052
6 Samples

Download data: BED, CEL

Series

Accession:: GSE32356

ID:: 200032356

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000323459.

Genome-wide maps of AR binding in prostate cancer cell lines VCaP and VCS2

(Submitter supplied) We report the high-throughput profiling of AR binding in prostate cancer cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: BED

Series

Accession:: GSE32345

ID:: 200032345

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003234410.

Expression profiling of prostate cancer VCaP and VCS2

(Submitter supplied) Microarray experiments were performed for VCaP and VCS2 cells with and without androgen stimulation

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE32344

ID:: 200032344

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003226911.

Expression data for primary localized prostate cancer versus castration-resistant bone metastatic prostate cancer

(Submitter supplied) We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle, proliferation, DNA synthesis, and androgen metablism are significantly increased in CRPC group. The expression of AR-stimulated genes were partially reactivated. TMPRSS2-ERG fusion status was determined for the samples by PCR. The expression of ERG was highly increased in fusion positive versus negative.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
55 Samples

Download data: CEL

Series

Accession:: GSE32269

ID:: 200032269

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003938812.

Distinct transcriptional programs controlled by ERG and ETV1 in prostate cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL1261 GPL5082 GPL570
43 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE39388

ID:: 200039388

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003935713.

ETV1 and ERG genome binding/occupancy profiling by genome tiling array

(Submitter supplied) Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. How these factors contribute to tumorigenesis and whether they play similar in vivo roles remain elusive. We show that ERG and ETV1 control a common transcriptional network but in an opposing fashion. In mice with ERG or ETV1 targeted to the endogenous Tmprss2 locus, either factors cooperated with Pten-loss, leading to localized cancer, but only ETV1 supported development of advanced adenocarcinoma, likely through enhancement of androgen receptor signaling and steroid biosynthesis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL5082
2 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE39357

ID:: 200039357

PubMed Full text in PMC Similar studies

Select item 20003935514.

Expression profiling of mouse primary prostate luminal cells from WT and T-ETV1 mice, which contains human ETV1 cDNA under the endogenous Tmprss2 promoter.

(Submitter supplied) Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. We here examine mouse prostate cells from WT mice with s with T-ETV1 mice, which contains express the truncated human ETV1 under the endogenous Tmprss2 promoter. ETV1 expression can be tracked by GFP expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
7 Samples

Download data: CEL

Series

Accession:: GSE39355

ID:: 200039355

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003935415.

Expression profiling of human prostate VCaP and LNCaP cancer cells after silencing ERG or ETV1, respectively

(Submitter supplied) Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. We here examine human prostate cancer cells control VCaP and LNCaP cells with ERG- or ETV1-silenced VCaP or LNCaP cells, respectively, in hormone deprived and stimulated conditions.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE39354

ID:: 200039354

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003935316.

Expression profiling of human prostate non-tumorigenic RWPE-1 cells after overexpressing ERG and ETV1, and ERG and ETV1 silencing on prostate cancer cells LNCaP and VCaP, respectively

(Submitter supplied) Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. We here examine human prostate non-tumorigenic RWPE-1 cells with ERG- or ETV1-expressing stable RWPE-1 cell.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE39353

ID:: 200039353

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009880917.

Loss of Function Mutations in ETS2 Repressor Factor (ERF) Reveal a Balance Between Positive and Negative ETS Factors Controlling Prostate Oncogenesis [VCaP ChIP-Seq]

(Submitter supplied) Half of prostate cancers are caused by a gene-fusion that enables androgens to drive expression of the normally silent ETS transcription factor ERG in luminal prostate cells1-4. Recent prostate cancer genomic landscape studies5-10 have reported rare but recurrent point mutations in the ETS repressor ERF11. Here we show these ERF mutations cause decreased protein stability and ERF mutant tumours are mostly exclusive from those with ERG fusions. more...