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Links from GEO DataSets

Items: 20

1.

Host responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein domains and host responses that contribute to rSARS-CoV-MA15-ΔE attenuation, several mutants (rSARS-CoV-MA15-E*) containing point mutations or deletions in the amino-terminal or the carboxy-terminal regions of E protein, respectively, were generated. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
15 Samples
Download data: TXT
Series
Accession:
GSE59185
ID:
200059185
2.

Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

(Submitter supplied) Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. more...
Organism:
Homo sapiens; Chlorocebus aethiops
Type:
Expression profiling by array
Platform:
GPL570
33 Samples
Download data: CEL
Series
Accession:
GSE30589
ID:
200030589
3.

Gene Expression Analysis of Host Immune Responses in CD11b positive cells isolated from lungs of the UV inactivated SARS-CoV-immunized mice following Lethal SARS-CoV Infection

(Submitter supplied) To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in macrophages from the lungs of mouse.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
24 Samples
Download data: TXT
Series
Accession:
GSE50855
ID:
200050855
4.

Gene Expression Analysis of Host Immune Responses in the UV inactivated SARS-CoV-immunized mice following Lethal SARS-CoV Infection

(Submitter supplied) To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in mouse lungs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
24 Samples
Download data: TXT
Series
Accession:
GSE44274
ID:
200044274
5.

SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

(Submitter supplied) Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
92 Samples
Download data: TXT
Series
Accession:
GSE33266
ID:
200033266
6.

SM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course

(Submitter supplied) This purpose of this experiment was to investigate the transcriptional differences between mice infected with SARS MA15 or SARS nsp16 mutant viruses.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
40 Samples
Download data: TXT
Series
Accession:
GSE49263
ID:
200049263
7.

The PDZ-binding motif of SARS-CoV envelope protein is a determinant of viral pathogenesis

(Submitter supplied) A recombinant SARS-CoV lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major virulence determinant in vivo. Elimination of SARS-CoV E protein PBM by using reverse genetics led to attenuated viruses (SARS-CoV-mutPBM) and to a reduction in the deleterious exacerbate immune response triggered during infection with the parental virus (SARS-CoV-wt). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
9 Samples
Download data: TXT
Series
Accession:
GSE52920
ID:
200052920
8.

Mouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice

(Submitter supplied) The purpose is to determine the role of TLR3-/- on the regulation of the host immune response during lethal SARS-CoV infection
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
52 Samples
Download data: TXT
Series
Accession:
GSE68820
ID:
200068820
9.

Absence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge

(Submitter supplied) To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy, physiology and clinical sequelae. The ferret, Mustela putorius furo, supports SARS-CoV replication and displays many of the symptoms and pathological features seen in SARS-CoV-infected humans. more...
Organism:
Mustela putorius furo; Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3738
38 Samples
Download data: CEL
Series
Accession:
GSE11704
ID:
200011704
10.

Immunization with Attenuated Equine Herpesvirus 1 Strain KyA Induces Innate Immune Responses that Protect Mice from Lethal Challenge

(Submitter supplied) Equine herpesvirus 1 (EHV-1) is a major pathogen affecting equines worldwide and causes respiratory disease, abortion, and in some cases, neurological disease. EHV-1 strain KyA is attenuated in the mouse and equine, whereas wild-type strain RacL11 induces severe inflammatory infiltration of the lung, causing infected mice to succumb at 4 to 6 days post-infection. Our previous results showed that EHV-1 KyA immunization protected CBA mice from pathogenic RacL11 challenge at 2 and 4 weeks post-immunization, and that the infection with the attenuated KyA elicits protective humoral and cell-mediated immune responses. To investigate the protective mechanisms of EHV-1 KyA by innate immune responses, CBA mice immunized with live KyA were challenged with RacL11 at various times post-vaccination. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
23 Samples
Download data: CEL, CHP, XLSX
Series
Accession:
GSE81219
ID:
200081219
11.

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL15103
16 Samples
Download data: TXT
Series
Accession:
GSE90624
ID:
200090624
12.

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

(Submitter supplied) Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets. more...
Organism:
Canis lupus familiaris; Mustela putorius furo
Type:
Expression profiling by array
Platform:
GPL3738
43 Samples
Download data: CEL
Series
Accession:
GSE22581
ID:
200022581
13.

Gene expression pattern of pulmonary CD11c+ cells from middle-aged and young mice.

(Submitter supplied) Analysis of function of CD11c+ cells from middle-aged and young mice at gene level. This experiment provided insight into the different genes that plays roles in inflammation, immune response and mainly arachidonic acid cascade that are differentiall expressed in CD11c+ cells from middle aged and young mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5879
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE71868
ID:
200071868
14.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
Download data
15.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(Submitter supplied) RNA was isolated from the lungs of mock and infected control and Trim55-/- mice at 2 and 4 DPI.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
21 Samples
Download data: TXT
Series
Accession:
GSE64660
ID:
200064660
16.

SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
438 Samples
Download data: TXT
Series
Accession:
GSE47963
ID:
200047963
17.

SHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-dORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
134 Samples
Download data: TXT
Series
Accession:
GSE47962
ID:
200047962
18.

SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-ddORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
141 Samples
Download data: TXT
Series
Accession:
GSE47961
ID:
200047961
19.

SHAE002: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-dORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
163 Samples
Download data: TXT
Series
Accession:
GSE47960
ID:
200047960
20.

RNA-Seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis

(Submitter supplied) We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression profiles to protein-coding genes of known function. To build a large panel of diverse host responses to viral infection, we took advantage of the genetic diversity present in the 8 founder strains of the Collaborative Cross (CC) mouse resource. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11002
123 Samples
Download data: TXT
Series
Accession:
GSE52405
ID:
200052405
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