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Links from GEO DataSets

Items: 20

1.

mRNA expression profile in IL-4-treated macrophages transfected with miR-142-5p ASO or miR-130a-3p mimics

(Submitter supplied) To identify target genes of miR-142-5p and miR-130a-3p that are involved in M2 polarization, we examined the mRNA expression profile changes after altering miR-142-5p or miR-130a-3p expression in IL-4-treated macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
12 Samples
Download data: TXT
Series
Accession:
GSE59347
ID:
200059347
2.

The differential miRNA expression induces M2 macrophage polarization and mediates their profibrogenic effects

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL13497 GPL17107
21 Samples
Download data: TXT
Series
Accession:
GSE59349
ID:
200059349
3.

M2 cytokines alter the miRNA expression profile in macrophages

(Submitter supplied) To examine the miRNA expression profile of the profibrogenic macrophages, we compared miRNA expression in untreated versus IL-4 or IL-13-treated macrophages using miRNA microarray.IL-4 and IL-13 treatment resulted in marked changes in 18 and 19 miRNAs in macrophages, respectively.(n=3, fold changes>2, P<0.05)
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL17107
9 Samples
Download data: TXT
Series
Accession:
GSE59348
ID:
200059348
4.

The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6246 GPL8786
21 Samples
Download data: CEL, CHP
Series
Accession:
GSE71644
ID:
200071644
5.

Negative control and mir-342-3p mimics-transfected RAW264.7 mouse macrophages.

(Submitter supplied) RAW264.7 mouse macrophages were transfected with negative control and miR-342-3p mimics and subjected to microarray analysis 18 hours after the transfection. We used microarray to obtain global mRNA expression data of negative control and miR-342-3p mimics-transfected RAW264.7 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE71642
ID:
200071642
6.

Human periheral blood-derived monocytes and unstimulated as well as IL-4-stimulated differentiating macrophages

(Submitter supplied) CD14+ monocytes were separated from human peripheral blood and exposed to IL-4 for 12 or 72 hours then subjected to microarray analysis We used Affymetrix miRNA1.0 microarray to obtain global miRNA expression data of human monocytes, unstimulated and IL-4-stimulated differentiating macrophages.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
15 Samples
Download data: CEL, CSV
Series
Accession:
GSE71641
ID:
200071641
7.

miR-221-3p drives the Shift of M2-Macrophage to a Pro-Inflammatory Function by Modulating JAK3/STAT3 Signaling and is Increased in Rheumatoid Arthritis

(Submitter supplied) We performed a transcriptome analysis of M2 macrophages generated in vitro from monocytes isolated from peripheral blood of healthy donors, and studied the effect of miR-221-3p mimic transfection and stimulation with LPS.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
20 Samples
Download data: TSV
Series
Accession:
GSE133527
ID:
200133527
8.

MiR-204-3p inhibits the production of TLR4-related cytokines in familial Mediterranean fever by targeting the PI3Kγ signaling pathway

(Submitter supplied) Our data suggest that serum miR-204-3p has a potential as a useful biomarker among patients with FMF and that miR-204-3p plays a critical role as a suppressor to regulate the production of TLR4-related cytokines by targeting PI3K signaling pathway.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
4 Samples
Download data: TXT
Series
Accession:
GSE98940
ID:
200098940
9.

MiRNA expression profile in murine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
28 Samples
Download data
Series
Accession:
GSE34648
ID:
200034648
10.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34647
ID:
200034647
11.

MiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34646
ID:
200034646
12.

MiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
8 Samples
Download data: XLSX
Series
Accession:
GSE34645
ID:
200034645
13.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: XLSX
Series
Accession:
GSE34644
ID:
200034644
14.

MicroRNA expression in thioglycollate and alternatively activated

(Submitter supplied) Macrophage activation must be tightly controlled to prevent overzealous responses that cause self-damage. MicroRNAs have been shown to promote classical macrophage activation by blocking concomitant anti-inflammatory signals and transcription factors, but can also place restraints on activation by preventing excessive TLR-signalling. In contrast, the microRNA profile associated with alternatively activated macrophages and their role in regulating wound-healing or anti-helminthic responses has not yet been described. more...
Organism:
Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL15121
14 Samples
Download data: TXT
Series
Accession:
GSE35047
ID:
200035047
15.

Experimental identification of miR-378-3p targets by overexpression and silencing in murine NIH-3T3 fibroblasts

(Submitter supplied) MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAs and their targets. We provide data here utilizing an experimental approach to identify targets of mmu-miR-378-3p, where mmu-miR-378-3p was overexpressed and silenced in NIH-3T3 murine fibroblasts and compared to control RNA transfected cells (RISC-free siRNA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL
Series
Accession:
GSE34873
ID:
200034873
16.

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

(Submitter supplied) Among the miRNAs regulated by IL-23, expression levels of 5 miRNAs were increased in T cells from patients with AS. The transfection of miR-29b-1-5p mimic could inhibit the IL-23-mediated STAT3 phosphorylation and might play a negative feedback control in the immunopathogenesis of AS.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL24741
6 Samples
Download data: TXT
Series
Accession:
GSE118806
ID:
200118806
17.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
141 Samples
Download data: TSV
Series
Accession:
GSE106706
ID:
200106706
18.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TSV
Series
Accession:
GSE106705
ID:
200106705
19.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
53 Samples
Download data: TSV
Series
Accession:
GSE106704
ID:
200106704
20.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [GRO-Seq]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: TSV
Series
Accession:
GSE106703
ID:
200106703
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