GEO DataSets

(Submitter supplied) p65-/-Ras cells show delayed tumor formation in SCID mice. However, after prolonged latency, tumor formation was observed from these mice. To understand the changes of NF-kB regulated genes before and after tumor formation, RNA from p65+/+Ras, p65+/+RasTumor, p65-/-Ras, p65-/-RasTumor cells were isolated and microarray were performed.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5608

Platform:

GPL1261

4 Samples

Download data: CEL, DCP, TXT

Analysis of p65+/+Ras and p65-/-Ras cells generated by infecting NF-κB subunit p65+/+ and p65-/- MEFs with pBabe-HRASG12V. Post-injection of the Ras cells into SCID mice, RasT tumors were removed, reconstituted in culture and examined. Results provide insight into role of NF-κB in tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE59545

4 Samples

Download data: CEL, DCP, TXT

(Submitter supplied) We look at differential gene expression between immortalized p65+/+ and p65-/- MEFs to identify potential NF-kB regulated genes which when grouped based on biological function indicates candidates involved in protecting p65+/+ cells from macrophage-mediated killing

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

2 Samples

Download data: TXT

(Submitter supplied) Purpose: To compared the gene expression profiles of splenocytes from wild type and UBLA4/GdX (Ubiquitin-like protein 4A, also named GdX) knockout mice upon LPS stimulation. Methods: GdX+/Y and GdX-/Y mice were injected with LPS. Their splenocytes were collected at different time (90min or 6 hrs), and then performed RNA-sequencing analysis. We sequence the samples used BGISEQ-500 platform. Results: The average mapping ratio with reference genome is 93.42%, the average mapping ratio with gene is 83.40%; A total of 17,920 genes were detected.A number of NF-κB targeting genes, such as IL-6, IL-1a and IL-12, have dramatic higher expressions in the splenocytes of GdX+/Y mice than that of GdX-/Y mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23479

7 Samples

Download data: XLS

(Submitter supplied) Developmental signals are known to modulate inflammation. How ever, the mechanistic insight that links developmental and inflammatory signaling remains elusive. In the current study, we identifya critical role of NF-kB system in mediating stimulus specific crosstalk that allows developmental LTbR signals to sustain inflammatory TLR4 induced RelA/NF-kB response and gene expression. LTbR activated non-canonical signaling targets canonical TLR4 induced, nfkb2 encoded p100 not only to deplete inhibitory IkBd/(p100)2, but also to supplement RelA:p52/NF-kB dimers. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5655

Platform:

GPL6885

4 Samples

Download data: TXT

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL6885

Series:

GSE62301

4 Samples

Download data

(Submitter supplied) Our study shows that TGF-β signaling promotes tumorigenesis in the liver through upregulation of its target gene, Snail. We explored gene expression changes in tumors following TGF-β inhibition, and tumors ectopically expressing Snail with the TGF-β inhibition. RNA samples were harvested from tumors expressing Smad7 (S7HP tumors), firefly luciferase (LHP tumors), and Smad7 plus Snail (S7HP+Snail), respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

9 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Expression profiling by array

Platforms:

GPL14189 GPL14360

320 Samples

Download data: CEL, TXT

(Submitter supplied) A custom microarray was used to measure the gene expression of NSCLC tumors. This represents a subset of samples which also have matched DNA copy number profiles from array CGH experiments

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14189

49 Samples

Download data: CEL

(Submitter supplied) Whole genome tiling path array CGH was used to measure the copy number profiles of 271 NSCLC tumors

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL14360

271 Samples

Download data: TXT