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Links from GEO DataSets

Items: 10

1.

Functional phenotypes alteration on dendritic cells between tolerance and immnunity

(Submitter supplied) Dendritic cells (DC) are key regulators of immunological responses, immunity and tolerance. Due to their differentiation capacities, they have emerged as a promising tool for therapeutic applications. However, there are poorly understood functional DC-specific markers and cellular mechanisms for in-vitro research and clinical usage. This study’s aim is to evaluate the gene expression profiling of up-regulated or down-regulated by DC maturation and explore their function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE59754
ID:
200059754
2.

Human monocyte-derived dendritic cells: Control vs Tolerogenic

(Submitter supplied) Transcriptional profiling of human dendritic cells (DC) comparing control (DC generated with GM-CSF plus IL-4) with three different treatments of tolerogenic (DC generated with GM-CSF plus IL-4 and IL-10, or IL-4, IL-10, and IL-6, or IL-4, IL-10, and TGF-b1)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9541
3 Samples
Download data: TXT
Series
Accession:
GSE18921
ID:
200018921
3.

High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells

(Submitter supplied) Human monocyte-derived dendritic cells (moDCs) have been used as an in vitro model for studying tolerance and immunity. However, the underlying metabolic states of tolerogenic (dexamethasone and vitamin D3-treated), immature and immunogenic (mature, LPS-treated) moDCs have not been completely characterized. Through transcriptomic analyses, we determined that tolerogenic moDCs exhibit augmented catabolic pathways with respect to oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO) and glycolysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
19 Samples
Download data: TXT
Series
Accession:
GSE52894
ID:
200052894
4.

Gene expression profile in CD11c+ splenic dendritic cells and CD11c+CD103+ dendritic cells from mesenteric lymph nodes (MLN) of mice with DC-specific targeting of TGFBR2

(Submitter supplied) Transcriptome analysis of dentritic cells from the spleen (CD11c+) or MLN (CD11c+CD103+) of mice with DC-specific deletion of TGFBR2 gene, or their control littermates. TRGFR2 gene was deleted in dendritic cells using Cre/lox approach. Mice with this deletion develop spontaneous multi-organ autoimmune inflammation and die by 15 weeks of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6096
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE39651
ID:
200039651
5.

Gene expression profiling of BM-derived dendritic cells reveals important mechanisms associated with predisposition to Staphylococcus infections

(Submitter supplied) Background: Staphylococcus aureus is a major pathogen of humans and animals and rapidly emerging antibiotic-resistant strains have further increased the severity of this health issue. Host genetics influence susceptibility to S. aureus infections, and genes determining infection outcome should be identified to analyze immune-based therapies as an alternative to antibiotics. Here, we used outbred animals from a divergent selection on susceptibility towards Staphylococcus infection to explore host immunogenetics. more...
Organism:
Ovis aries
Type:
Expression profiling by array
Platform:
GPL10427
44 Samples
Download data
Series
Accession:
GSE24448
ID:
200024448
6.

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

(Submitter supplied) The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Selective disruption of these interactions induced the typical features of DC maturation including the upregulation of costimulatory molecules, MHC class II, and chemokine receptors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
17 Samples
Download data: CEL, CHP
Series
Accession:
GSE9241
ID:
200009241
7.

Comparative gene expression profile of 1,25-dihydroxyvitamin D3-treated human monocyte-derived dendritic cells

(Submitter supplied) We have carried out global gene expression analysis to clarify the interrelationship between 1,25-dihydroxyvitamin D3 and differentiation-driven gene expression patterns in developing human monocyte-derived dendritic cells. Monocytes were treated with 10 nM 1,25-dihydroxyvitamin D3 or vehicle 14 hours after plating for 12 hours or 5 days. Monocytes, differentiating dendritic cells (+/-1,25-dihydroxyvitamin D3 for 12 hours) and immature dendritic cells (+/-1,25-dihydroxyvitamin D3 for 5 days) were harvested. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
15 Samples
Download data: CEL
Series
Accession:
GSE13762
ID:
200013762
8.

Gene expression in Mouse thrombomoudlin+ and thrombomodulin- dendritic cell

(Submitter supplied) Previously we had shown in a mouse model of bronchial asthma that thrombomodulin (TM; CD141; BDCA3) can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on the cell surface. Thrombomodulin+ dendritic cells are tolerogenic while thrombomodulin- dendritic cells are pro-inflammatory and immunogenic. Here we hypothesized that thrombomodulin treatment of dendritic cells would modulate inflammatory gene expression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
36 Samples
Download data: CEL
Series
Accession:
GSE45652
ID:
200045652
9.

Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors

(Submitter supplied) Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs changes with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. We identified up and down-regulated gene expression changes in DC from aged donors compared to young donors.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5286
Platform:
GPL571
9 Samples
Download data: CEL
Series
Accession:
GSE58015
ID:
200058015
10.
Full record GDS5286

Monocyte-derived dendritic cells from young and aged donors

Comparison of dendritic cells (DCs) from young (20 to 27 years) and aged (77 to 87 years) donors. DCs are antigen-presenting cells important in initiating and regulating innate and adaptive immune responses. Results provide insight into the molecular basis of the decline in DC function with age.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL571
Series:
GSE58015
9 Samples
Download data: CEL
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