GEO DataSets

(Submitter supplied) The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. more...

Organism:

Candida albicans; Candida albicans SC5314

Type:

Genome variation profiling by array

Platform:

GPL19026

3 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Candida albicans SC5314

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL19026 GPL19049

19 Samples

Download data: TXT

(Submitter supplied) The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL19049

16 Samples

Download data: TXT

(Submitter supplied) To investigate how organisms mitigate the deleterious effects of mistranslation during evolution, a mutant tRNA was expressed in S. cerevisiae. The expression of Candida Ser-tRNACAG from a low copy plasmid in S. cerevisiae promoted mistranslation events by random incorporation of both serine and leucine at CUG codons. As mistranslation causes an overload of the protein quality pathways, it disrupts cellular protein homeostasis leading to a major fall in fitness. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL9825

22 Samples

Download data: TXT

(Submitter supplied) Here we provide, for the first time, a longitudinal study of the prevalence, dynamics, and fixation of gross chromosomal rearrangements, including aneuploidy, in the presence and absence of fluconazole during a well-controlled in vitro evolution experiment. While no aneuploidy was detected in any of the no-drug control populations, in all fluconazole-treated populations analyzed, isochromosome 5L [i(5L)] appeared soon after drug exposure, was associated with increased fitness in the presence of drug, and became fixed in independent populations. more...

Organism:

Candida albicans

Type:

Genome variation profiling by array

Platforms:

GPL8566 GPL8479 GPL8481

34 Samples

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(Submitter supplied) Differential expression of isolates of Candida albicans grown in YPD using RNA-Seq.

Organism:

Candida albicans

Type:

Third-party reanalysis; Expression profiling by high throughput sequencing

Download data: TXT