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Links from GEO DataSets

Items: 19

1.

Transcriptional and functional characterization of dendritic cell differentiation induced by CD137 ligand reverse signaling in human monocytes

(Submitter supplied) The contribution of monocyte-derived dendritic cells (DC) to an immune response is essential for the elimination of pathogens. In vitro DC can be generated by treatment of monocytes with GM-CSF + IL-4 but it is unknown what stimuli induce the differentiation of monocytes to DC in vivo. CD137L-DC are human monocyte-derived DC that are generated by CD137 ligand (CD137L) signaling. Since CD137 is only expressed at sites of inflammation it would be a suitable signal for the induction of monocyte-derived DC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
30 Samples
Download data: TXT
Series
Accession:
GSE60199
ID:
200060199
2.

Time-dependent regulation of cellular programming of monocytes by NCOR2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL10558 GPL18460 GPL6947
77 Samples
Download data
Series
Accession:
GSE96719
ID:
200096719
3.

Time-dependent regulation of cellular programming of monocytes by NCOR2 [RNASeq_TK]

(Submitter supplied) Whole transcriptome profiling (RNA-Seq) of a time kinetics experiment containing human monocyte-derived cells, which were activated with IL4 either directly at the start of the culture, or at different hours after an initial activation with GMCSF alone. Cells being activated solely with GMCSF were added as controls
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
20 Samples
Download data: TXT
Series
Accession:
GSE96715
ID:
200096715
4.

Time-dependent regulation of cellular programming of monocytes by NCOR2 [RNASeq_KD]

(Submitter supplied) Whole transcriptome profiling (RNA-Seq) was performed on human Mo-GMCSF[IL4 (0-72h)] cells with either NCOR2 being knocked down or corresponding WT cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
6 Samples
Download data: TXT
Series
Accession:
GSE96713
ID:
200096713
5.

Time-dependent regulation of cellular programming of monocytes by NCOR2 [Illumina array]

(Submitter supplied) Whole transcriptome profiling (Illumina Microarray) of human ex vivo lymphocytes and monocytes, as well as of human monocyte-derived cells generated in vitro by activating CD14+ monocytes with MCSF, GMCSF or the combination of GMCSF and IL4
Organism:
Homo sapiens
Type:
Expression profiling by array; Third-party reanalysis
Platforms:
GPL6947 GPL10558
51 Samples
Download data: TXT
Series
Accession:
GSE96703
ID:
200096703
6.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL10333 GPL4134
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE39863
ID:
200039863
7.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [A]

(Submitter supplied) T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific activation process, triggered by specialized dendritic cells (DCs), by which naive CD4+ Th0 cells acquire the capacity to produce Th2 cytokines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
4 Samples
Download data: GPR
Series
Accession:
GSE39862
ID:
200039862
8.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [B]

(Submitter supplied) T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific activation process, triggered by specialized dendritic cells (DCs), by which naive CD4+ Th0 cells acquire the capacity to produce Th2 cytokines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE39858
ID:
200039858
9.

Mesenchymal stromal cells perturb human monocyte in vitro differentiation into dendritic cells

(Submitter supplied) Monocytes cultured in media containing GM-CSF and IL4 for 5 days normally differentiate into immature dendritic cells which, upon further stimulation with LPS for an additional 2 days, acquire a mature phenotype. In the present study, we evaluated the effect of human cord-blood mesenchymal stem cells (MSC) on human monocyte differentiation into immature and mature DCs by examining the trancriptional profile of the cells that were obtained after both the differentiation and maturation stages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
18 Samples
Download data: TXT
Series
Accession:
GSE68962
ID:
200068962
10.

Expression data from human monocyte-derived dendritic cells treated or not with interleukin 17A (IL-17A)

(Submitter supplied) IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodeling of lipid metabolism in human monocyte-derived DC, as revealed by microarrays analysis. In particular NR1H3/LXR-a and its target genes were significantly upregulated in response to IL-17A. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5817
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE53163
ID:
200053163
11.
Full record GDS5817

Interleukin 17A effect on monocyte-derived dendritic cells

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol, 2 time sets
Platform:
GPL570
Series:
GSE53163
9 Samples
Download data: CEL
12.

Single-cell RNA-seq analysis of human CD14+ monocytes

(Submitter supplied) We performed single-cell RNA-seq on CD14+ monocytes isolated from the blood of healthy donors. Using the 10x chromium technology, we analyzed 425 and 431 cells from 2 individual donors.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
2 Samples
Download data: CSV
Series
Accession:
GSE103544
ID:
200103544
13.

Transcriptomic analysis of in vitro-generated human monocyte-derived cells

(Submitter supplied) We analyzed the transcriptomes of human dendritic cells and macrophages derived from monocytes using MCSF + IL-4 + TNFa, or IL-34 + IL-4 + TNFa, or dendritic cells derived from monocytes using GMCSF + IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
30 Samples
Download data: CEL
Series
Accession:
GSE102046
ID:
200102046
14.

BDCA1+ mDCs and BDCA3+ mDCs stimulated with vaccines for 6 hr

(Submitter supplied) The mechanisms by which vaccines interact with human APCs remain elusive. We applied systems biology to define the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Upon exposing DCs to influenza, Salmonella enterica and Staphylococcus aureus, we built a modular framework containing 204 pathogen-induced transcript clusters. Module fingerprints were then analyzed in DCs activated with 16 innate receptor ligands. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
88 Samples
Download data: TXT
Series
Accession:
GSE56744
ID:
200056744
15.

Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL6947
413 Samples
Download data
Series
Accession:
GSE44722
ID:
200044722
16.

IL4 DCs and monocytes stimulated by 13 human vaccines and LPS for 6hr

(Submitter supplied) While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DCs (moDCs) in vitro in response to influenza H1N1 Brisbane, Salmonella enterica and Staphylococcus aureus. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
128 Samples
Download data
Series
Accession:
GSE44721
ID:
200044721
17.

IFNa DCs and IL4 DCs exposed to H1N1, heat killed S. aureus, or heat killed S. enterica (HKSE) for 1h, 2h, 6h, 12h, or 24h

(Submitter supplied) While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DCs (moDCs) in vitro in response to influenza H1N1 Brisbane, Salmonella enterica and Staphylococcus aureus. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
120 Samples
Download data: TXT
Series
Accession:
GSE44720
ID:
200044720
18.

IFNa and IL4 DCs stimulated with microbial components for 6hr

(Submitter supplied) While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DCs (moDCs) in vitro in response to influenza H1N1 Brisbane, Salmonella enterica and Staphylococcus aureus. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
77 Samples
Download data: TXT
Series
Accession:
GSE44719
ID:
200044719
19.

Comparison of the PU.1 transcriptional regulome and interactome in human and mouse dendritic cells

(Submitter supplied) Dendritic cells (DCs) are key immune modulators, and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed transcription factor in DCs, and coordinates relevant aspects of DC biology. Due to their role as immune regulators, DCs pose as a promising immunotherapy tool. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: TXT
Series
Accession:
GSE157844
ID:
200157844
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