Similar studies for GEO DataSets (Select 200060247) - GEO DataSets

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Items: 20

Select item 2000602471.

PPARγ controls alveolar macrophage identity [part1]

(Submitter supplied) Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARγ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
8 Samples

Download data: CEL

Series

Accession:: GSE60247

ID:: 200060247

Select item 2000602492.

PPARγ controls alveolar macrophage identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
12 Samples

Download data: CEL

Series

Accession:: GSE60249

ID:: 200060249

Select item 2000602483.

PPARγ controls alveolar macrophage identity [part2]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
4 Samples

Download data: CEL

Series

Accession:: GSE60248

ID:: 200060248

Select item 2000887684.

Identification of PPARG regulated genes in human GM-CSF-primed monocyte-derived macrophages

(Submitter supplied) Identification of PPARG regulated genes in human GM-CSF polarized monocyte-derived macrophages by siRNA knock-down approaches.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
6 Samples

Download data: TXT

Series

Accession:: GSE88768

ID:: 200088768

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000769995.

Capacity of yolk sac macrophages, fetal liver and adult monocytes to colonize an empty niche and develop into functional tissue resident macrophages

(Submitter supplied) Tissue-resident macrophages can derive from yolk sac macrophages, fetal liver monocytes or adult bone marrow monocytes. Whether these precursors can give rise to transcriptionally identical alveolar macrophages is unknown. Here, we transferred traceable yolk sac macrophages, fetal liver monocytes, adult bone marrow monocytes or adult alveolar macrophages as a control, into the empty alveolar macrophage niche of neonatal Csf2rb-/- mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
36 Samples

Download data: CEL

Series

Accession:: GSE76999

ID:: 200076999

Select item 2001902596.

Expression data from human alveolar macrophages (AMs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
17 Samples

Download data: CEL, CHP

Series

Accession:: GSE190259

ID:: 200190259

PubMed Full text in PMC Similar studies

Select item 2001902577.

Expression data from human alveolar macrophages (AMs) of fetal versus adult origin

(Submitter supplied) The impact of cell origin on human lung macrophage identity and function remains unknown. In this study we characterized human alveolar macrophages of fetal versus adult origin. We used microarray to define the gene signatures of human alveolar macrophages derived from CD116+CD64+ fetal monocytes, CD116+CD64- fetal precursors, and CD34+ HSPCs in MISTRG humanized mice.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE190257

ID:: 200190257

PubMed Full text in PMC Similar studies

Select item 2001902568.

Expression data from different types of human alveolar macrophage (AM) precursors

(Submitter supplied) Despite their importance in lung health and disease, it remains unknown how human alveolar macrophages develop early in life. In this study we identified the fetal progenitor of human alveolar macrophages. We used microarray to define the gene signatures of human CD14+ blood monocytes (adult AM precursors), CD116+CD64+ fetal liver monocytes, and CD116+CD64- fetal AM precursors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE190256

ID:: 200190256

PubMed Full text in PMC Similar studies

Select item 2000474739.

Global gene expression profiling using total RNA [BMM, MPI and SPG]

(Submitter supplied) Differentiation of myeloid progenitor cells leads to distinct populations of mononuclear phagocytes.Various macrophages exhibit distinct biological properties. Here wanted to delineate and characterize gene expression patterns in bone marrow derived macrophages Here wanted to delineate and characterize gene expression patterns in two newly established, self-renewing, in vitro grown non-transformed lines (MPI cells) and in the SP37A3 immature myeloid dendritic cell line. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE47473

ID:: 200047473

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005405010.

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.

(Submitter supplied) Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bach2) developed PAP-like accumulation of surfactant proteins in the lungs. Bach2 was expressed in AMs, and Bach2-deficient AMs showed alterations in lipid handling in comparison with wild-type (WT) cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
4 Samples

Download data: TXT

Series

Accession:: GSE54050

ID:: 200054050

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014064511.

Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development

(Submitter supplied) We studied alveolar macrophage (AM) development after single and competitive transplantation of different precursors from YS, fetal liver, and lung into neonatal Csf2ra-/- mice, which lack endogenous AM. Fetal monocytes, promoted by Myb, outcompeted primitive MΦ (pMΦ) in empty AM niches and preferentially developed to mature AM, which is associated with enhanced mitochondrial respiratory and glycolytic capacity and repression of the transcription factors c-Maf and MafB. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
14 Samples

Download data: CSV

Series

Accession:: GSE140645

ID:: 200140645

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019353712.

Gene therapy of Csf2ra-/- deficiency in long-term cultured fetal monocyte precursors restores bona fide alveolar macrophage development and function in mice

(Submitter supplied) Tissue-resident macrophage-based immune therapies have been proposed for various diseases. However, generation of sufficient numbers that possess tissue-specific functions remains a major handicap. Here, we show that fetal liver monocytes cultured with GM-CSF (CSF2-cFLiMo) rapidly differentiate into a long-lived, homogeneous alveolar macrophage (AM)-like population in vitro. CSF2-cFLiMo remained the capacity to develop into bona fide AM upon transfer into Csf2ra-/- neonates and prevented development of alveolar proteinosis and accumulation of apoptotic cells for at least 1 year in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30172 GPL17021
10 Samples

Download data: CSV, TXT

Series

Accession:: GSE193537

ID:: 200193537

PubMed Full text in PMC Similar studies

Select item 20003203413.

Tissue-specific differences in PPARγ control of macrophage function.

(Submitter supplied) PPARγ is known for its anti-inflammatory actions in macrophages. However, which macrophage populations express PPARγ in vivo and how it regulates tissue homeostasis in the steady state and during inflammation is not completely understood. We show that lung and spleen macrophages constitutively expressed PPARγ, while other macrophage populations did not. Recruitment of monocytes to sites of inflammation was associated with induction of PPARγ as they differentiated to macrophages. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
14 Samples

Download data: CEL

Series

Accession:: GSE32034

ID:: 200032034

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016608514.

PPARγ is essential for the development of erythroblastic island macrophages and red pulp macrophages

(Submitter supplied) Macrophages in the bone marrow erythroblastic island (EIM) and splenic red pulp (RPM) are required for terminal erythropoiesis and removal of aged erythrocytes, respectively. This manuscript shows that EIM and RPM development require both PPARg and Spi-C.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL24247
23 Samples

Download data: TXT

Series

Accession:: GSE166085

ID:: 200166085

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018204415.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: MTX, RDS, TSV, TXT

Series

Accession:: GSE182044

ID:: 200182044

PubMed Full text in PMC Similar studies

Select item 20018204316.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair [Alveolar macrophages]

(Submitter supplied) We compare the transcriptional profile of Egr2-sufficient or Egr2-deficient airway macrophages obtained from Lyz2-Cre-Egr2-floxed mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: CSV, TXT

Series

Accession:: GSE182043

ID:: 200182043

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018189417.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair [myeloid cells]

(Submitter supplied) We profile the transcriptomes of over 3,000 mouse single myeloid cells from mouse lung to define the transcriptional profiles of monocytes and subsets of dendritic cells and macrophages. We perform differential gene expression analysis to determine the transcriptional regulators unique to each cluster.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
1 Sample

Download data: MTX, RDS, TSV

Series

Accession:: GSE181894

ID:: 200181894

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014668318.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
12 Samples

Download data

Series

Accession:: GSE146683

ID:: 200146683

PubMed Full text in PMC Similar studies

Select item 20014668219.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties [scRNA-seq]

(Submitter supplied) Tissue-resident macrophages are a diverse population of cells that perform specialized functions including sustaining tissue homeostasis and tissue surveillance. Here we report an interstitial subset of CD169+ lung-resident macrophages that are transcriptionally and developmentally distinct from alveolar macrophages (AMs). They are primarily localized around the airways and are found in close proximity to the sympathetic nerves located in the bronchovascular bundle. more...