GEO DataSets

(Submitter supplied) This study was designed to identify molecular changes induced by radiation in mouse lung.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

9 Samples

Download data: TXT

(Submitter supplied) Background: In the event of an improvised nuclear device detonation, the prompt radiation exposure would consist of γ rays plus a neutron component that would contribute to the total dose. As neutrons cause more complex and difficult to repair damage to cells that would result in more severe health burden to affected individuals, it is paramount to be able to estimate the contribution of neutrons to an estimated dose, to provide information for those making treatment decisions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

72 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse kidney cortex and medulla following 177Lu irradiation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

72 Samples

Download data: TXT

(Submitter supplied) Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged animals. We demonstrate that NOX4 expression and superoxide elaboration is increased in irradiated lungs and pneumocytes in a dose dependent fashion. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4822

Platform:

GPL1261

45 Samples

Download data: CEL

Analysis of total lung from C57Bl/Ncr females exposed to 0, 5, or 17.5 Gy at 2, 4, 8, 16, and 30 weeks after thoracic irradiation. The lungs show extensive fibrosis at 30 weeks after 17.5 Gy. Results provide insight into molecular mechanisms underlying radiation-induced pulmonary fibrosis (RIPF).

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 dose, 5 time sets

Platform:

GPL1261

Series:

GSE41789

45 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) The aim of our research is to clarify the mechanisms generating heterogeneity in response to C-ion irradiation that arise from individual genetic variations in humans. In this study, we performed whole lung C-ion irradiation using three different strains of mice to examine whether strain-dependent differences in radiation effects occur in high-LET C-ion thoracic irradiation. Murine strain-variance was evaluated by histopathological examination of intra-alveolar hemorrhage that is likely to occur during the early phase after irradiation, and of lung fibrosis during the late phase, occurring more than three months after irradiation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

108 Samples

Download data: TXT

(Submitter supplied) Expression profiles in mouse liver exposed to long-term gamma-irradiation were examined to assess in vivo effects of low dose-rate radiation. Three groups of male C57BL/6J mice were exposed to whole body irradiation at dose-rates of 17-20 mGy/day, 0.86-1.0 mGy/day or 0.042-0.050 mGy/day for 401-485 days (cumulative doses were approximately 8 Gy, 0.4 Gy or 0.02 Gy, respectively). Expression profiles were produced for RNA isolated from irradiated individual animals and for pooled RNA from sham-irradiated 3 animals for control. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

20 Samples

Download data: CEL, CHP

(Submitter supplied) Based on gene expression changes measured in the peripheral blood within the first 2 days after irradiation we aimed to predict the later occurring hematological acute radiation syndrome (HARS). Altogether 18 baboons were irradiated simulating different patterns of partial body irradiation or total body irradiation corresponding to an equivalent dose of 2.5 or 5 Gy. According to changes in blood cell counts (BCC) they were either suffering from H1-2 (n=4) or H2-3 (n=13) degree HARS. more...

Organism:

Homo sapiens; Papio papio

Type:

Expression profiling by array

Platform:

GPL17077

23 Samples

Download data: TXT

(Submitter supplied) Measuring global gene expression using cDNA or oligonucleotide microarrays is an effective approach to understanding the complex mechanisms of the effects of radiation. However, few studies have been carried out that investigate gene expression in vivo after prolonged exposure to low-dose-rate radiation. In this study, C57BL/6J mice were continuously irradiated with γ-rays for 485 days at dose-rates of 0.032 – 13 μGy/min. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

24 Samples

Download data: CSV

(Submitter supplied) Female BALB/c nude mice (n=3/group) were subjected to partial body irradiation under anesthesia using 2 Gy external photon (4 MV, nominal) irradiation. In group A, the collum (i.e. the thyroid) was irradiated; in group B, thorax+abdomen were irradiated, and in group C, collum+thorax+abdomen were irradiated. The control group (n=5) was anesthetized but not irradiated. At 24 h after treatment, the kidneys, liver, lungs, spleen, and thyroid were excised, flash-frozen, and stored at -80°C. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

88 Samples

Download data: TXT

(Submitter supplied) Adopting boron neutron capture, we separately irradiated Kupffer cells and endothelial cells in mouse liver in vivo and the changes in gene transcriptions were analyzed by an oligonucleotide microarray. Keywords: Gene expression

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL5978 GPL5984

8 Samples

Download data: TXT

(Submitter supplied) The present work identified gene expression changes in response to total body irradiation (TBI) in heart, lungs, and liver tissue in Gottingen minipigs. Animals were exposed to 1.7 Gy, 1.9 Gy, 2.1 Gy and 2.3 Gy of TBI and were followed for 45 days. Organ samples were collected at the end of 45 days or sooner if the animal displayed morbidity necessitating euthanasia. RNA was extracted and gene expression profiling studied using Agilent arrays.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

90 Samples

Download data: TXT, XLSX

(Submitter supplied) Background: The effects of dose-rate and its implications on radiation biodosimetry methods are not well studied in the context of large-scale radiological scenarios. There are significant health risks to individuals exposed to an acute dose in such an event, but the most realistic scenario would be a combination of exposure to both high and low dose-rates, from both external and internal radioactivity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

35 Samples

Download data: TXT

(Submitter supplied) We have developed a new model of radiation-induced liver fibrosis and aimed to understand the underlying mechanism using RNAseq.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

35 Samples

Download data: TXT

(Submitter supplied) The objective of this investigation was to characterize, at individual level, the transcriptional response and the onset of regenerative processes in mouse skin irradiated with different doses of fast neutrons. We performed a high-throughput gene expression analysis, by DNA oligonucleotide microarray on 24 three months old C57Bl/6 mice irradiated with 0, 0,2 and 1 Gy of mono-energetic 14 MeV neutron. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11211

8 Samples

Download data: GPR

(Submitter supplied) XPA is required for Nucleotide Excision Repair system, which could function to repair DNA damage induced by the UV. UV damage on the genomic DNA cannot be removed, thus persistence of damage could affect the transcriptional machinary. We used the microarray to investigate the global expression profiles in the XP-A and XP-V cells in the low dose of UVC comparing with fibroblast from healthy person.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

11 Samples

Download data: CEL, CHP

(Submitter supplied) Background: In the event of an improvised nuclear device or radiological dirty bomb detonation large numbers of people will be exposed to radiation that would require a timely and accurate biodosimetry to identify the highly exposed individuals who would require medical treatment from those who have received low or no radiation (the “worried well”). Gene expression signatures in response to radiation have been derived from mice and human peripheral blood and the impact of a number of variables, such as dose, time, genotype, and gender, on gene expression has been analyzed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11202

24 Samples

Download data: TXT

(Submitter supplied) A set of changes is identified in the transcription profile associated with the long-term, but not the acute, response to radiation exposure. The study was performed in vivo using zebrafish. To study the long-term response, 24 hour post-fertilization embryos were exposed to 0.1 Gy (low dose) or 1.0 Gy (moderate dose) of whole-body gamma radiation and allowed to develop for 16 weeks. Liver mRNA profiles were then analyzed using the Affymetrix microarray platform, with validation by quantitative PCR. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

15 Samples

Download data: CEL