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Links from GEO DataSets

Items: 20

1.

miR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.

(Submitter supplied) We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics resulted in reduced expression of myogenic differentiation markers including Troponin T, myosin heavy chain fast and slow type.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL18466
3 Samples
Download data: TXT
Series
Accession:
GSE63454
ID:
200063454
2.

Guanidineacetic acid regulate myogenic differentiation through miR-133a-5 and miR-1a-3p co-mediated PI3K-Akt-mTOR signaling pathway

(Submitter supplied) Through small RNA sequencing, we finded that a total of 8 miRNAs, including miR-133a-3p and miR-1a-3p cluster, showed differential expression after guanidineacetic acid supplement. To further study the function of miR-133a-3p and miR-1a-3p in guanidineacetic acid induce myotube hypertrophy, we transfected miR-133a-3p and miR-1a-3p mimics, that also induce myotube hypertrophy. Through bioinformatics and dual-luciferase reporter system, the target gene of miR-133a-3p and miR-1a-3p were respectively determined. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE118528
ID:
200118528
3.

miRNA-transcriptome expression pattern during differentiation in human skeletal muscle cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL15829 GPL11532
44 Samples
Download data: CEL, TXT
Series
Accession:
GSE53384
ID:
200053384
4.

Dynamic time course miRNA profiling of human skeletal muscle cell differentiation.

(Submitter supplied) The purpose of this study was to determine the miRNA expression profile of in vitro differentiation of human skeletal muscle cells and to couple changes in individual miRNA expression to transcriptional output of target genes. miRNA expression profiling at six different time points during the in vitro differentiation process of human skeletal muscle cells from six subjects. RNA was harvested from myoblasts before induction of differentiation and at every other day for 10 following days.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL15829
35 Samples
Download data: TXT
Series
Accession:
GSE53383
ID:
200053383
5.

Dynamic time course mRNA profiling of human skeletal muscle cell differentiation.

(Submitter supplied) The purpose of this study was to determine the miRNA expression profile of in vitro differentiation of human skeletal muscle cells and to couple changes in individual miRNA expression to effects on target genes by transcriptome profiling of mRNA expression. mRNA expression profiling at three different time points during the in vitro differentiation process of human skeletal muscle cells from three subjects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
9 Samples
Download data: CEL
Series
Accession:
GSE53382
ID:
200053382
6.

microRNA expression during skeletal muscle differentiation and exercse in skeletal muscle.

(Submitter supplied) To investigate microRNAs related to mitochondria biogenesis in skeletal muscle, microRNA expressions during skeletal muscle differentiation and exercise were analyzed in vivo and in vitro.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL13533
6 Samples
Download data: GPR
Series
Accession:
GSE29286
ID:
200029286
7.

Ethanol effect on myoblast differentiation

(Submitter supplied) Expression profiling of C2C12 myoblast cells treated with ethanol during differentiation. Ethanol inhibits C2C12 differentiation. Results provide insight into signaling pathways altered by ethanol during differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5370
Platform:
GPL6885
24 Samples
Download data: TXT
Series
Accession:
GSE46492
ID:
200046492
8.
Full record GDS5370

Ethanol effect on myoblast differentiation in vitro

Analysis of C2C12 cells cultured for up to 3 days in differentiation medium containing ethanol. Chronic alcoholics suffer from weakness and locomotor difficulty resulting from muscle damage. Results provide insight into the signaling pathways affected by ethanol in differentiating myoblasts.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL6885
Series:
GSE46492
24 Samples
Download data
9.

circRNA expression in C2C12 myoblasts and myotubes

(Submitter supplied) To determine the circRNA expression profile in C2C12 myoblasts and myotubes, we used mouse circRNA microarray from Arraystar to examine the expression of circRNAs in C2C12 myoblasts and myotubes.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL21826
6 Samples
Download data: TXT
Series
Accession:
GSE112014
ID:
200112014
10.

High-throughput sequencing identifies miRNAs and their targets involved in porcine muscle development

(Submitter supplied) To identify miRNAs involved in muscle development, three independent small RNA libraries from porcine skeletal muscle at the age of 63d、98d and 161d were constructed. A total of 4105184, 4606375 and 5113984 mappable small RNA sequences were generated in the three small RNA libraries, respectively, and 887 known and 472 new candidate miRNAs were obtained.
Organism:
Sus scrofa
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11429
3 Samples
Download data: TXT
Series
Accession:
GSE64275
ID:
200064275
11.

MUNC downregulation decreases muscle differentiation

(Submitter supplied) Gene expression profiling in differentiating C2C12 cells comparing control cells and MUNC-deprived cells
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6096
4 Samples
Download data: CEL
Series
Accession:
GSE63673
ID:
200063673
12.

MicroRNA expression in bovine satellite cells at 6th day of in vitro differentiation - myotubes (Hereford & Limousin vs Holstein-Freisian cattle)

(Submitter supplied) miRNA profiling of bovine satellite cells (BSC) differentiated into myotubes (6th day of in vitro differentiation). BSC isolated from m. semitendinosus of beef (Hereford & Limousine) and dairy (Holstein-Friesian) cattle. Goal was to determine differences in miRNA expresion during in vitro myogenesis in beef vs dairy cattle used as a control.
Organism:
Bos taurus
Type:
Non-coding RNA profiling by array
Platform:
GPL19028
24 Samples
Download data: TXT
Series
Accession:
GSE73778
ID:
200073778
13.

Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts

(Submitter supplied) The differentiation and regeneration of skeletal muscle from myoblasts to myotubes involves myogenic transcription factors, such as myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). In addition, post-transcriptional regulation by miRNAs is required during myogenesis. Here we provide evidence for novel mechanisms regulating MRTF-A during myogenic differentiation. Endogenous MRTF-A protein abundance and activity decreased during C2C12 differentiation, which was attributable to miRNA-directed inhibition. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16173
18 Samples
Download data: CSV
Series
Accession:
GSE136956
ID:
200136956
14.

Novel players in myogenesis identified by target validation for muscle specific microRNAs in C2C12 myoblasts

(Submitter supplied) Search of novel miR-206 target genes in C2C12 cells, based on differential expression of transcripts containing putative miR-206 binding sites. miR-206 candidate target genes were hpothesized to be upregulated in AM206 vs Day2 sample and downregulated in siRNA vs Day 1 sample.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE34069
ID:
200034069
15.

Differential microRNA Expression during Myogenic Progenitor Cell Proliferation and Differentiation

(Submitter supplied) MicroRNAs (miRNAs) are important in the regulation of many biological processes such as growth and development. To evaluate the role of miRNAs in skeletal muscle regeneration, global miRNA expression was measured during muscle cell growth and differentiation. Primary cultures of murine myogenic progenitor cells (MPC) were studied for miRNA expression using quantitative PCR-array. During MPC differentiation or proliferation, 139 or 16 miRNAs, respectively, exhibited significant >2-fold changes. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL8527
7 Samples
Download data: TXT
Series
Accession:
GSE16473
ID:
200016473
16.

Circular RNAs in cattle muscle: developmental stage-dependent changes

(Submitter supplied) Circular RNAs (circRNAs) have been identified in various tissues and cell types from human, monkey, porcine and mouse. However, expression profile of circRNAs across cattle muscle development has never been investigated. Here, we examine the expression of circRNA in cattle skeletal muscle at embryonic stage and adult stage, exhibiting the first report of circRNA in the cattle muscle development of a large animal. more...
Organism:
Bos taurus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL19172
7 Samples
Download data: XLSX
Series
Accession:
GSE87908
ID:
200087908
17.

Differential microRNA Expression during Muscle Regeneration

(Submitter supplied) MicroRNAs (miRNAs) are important in the regulation of many biological processes including muscle development. However, little is known regarding miRNA regulation of muscle regeneration. In mature murine tibialis anterior muscle following injury, 298 miRNAs were significantly changed during the time course of muscle regeneration including 86 that were altered greater than 10-fold as compared to uninjured muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL8527
5 Samples
Download data: TXT
Series
Accession:
GSE37479
ID:
200037479
18.

The role of microRNAs in hepatic thyroid hormone signalling

(Submitter supplied) MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic balance in mammals. We induced transient hypothyroidism in juvenile mice by short term exposure to methimazole and perchlorate from post natal day (PND) 12 to 15. more...
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Other
Platforms:
GPL4134 GPL10331
18 Samples
Download data: TXT
Series
Accession:
GSE21277
ID:
200021277
19.

Dysregulation of a miR-23b/27b-p53 axis impairs muscle differentiation in humans with type 2 diabetes

(Submitter supplied) Impaired skeletal muscle function is a central feature in the pathophysiology of type 2 diabetes (T2DM). The disease phenotype could be due to immature muscle cell development, which in turn may occur as the result of disturbed microRNA-mediated regulation of muscle differentiation in T2DM. To address this hypothesis, we assessed global miRNA expression during in vitro differentiation of muscle stem cells derived from T2DM patients and healthy controls. more...
Organism:
Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human betaherpesvirus 6B; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; Saimiriine gammaherpesvirus 2; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL22371
47 Samples
Download data: TXT
Series
Accession:
GSE86069
ID:
200086069
20.

Single-nucleus RNA-seq on undifferentiated human KD3 myoblasts and differentiated myotubes and mononucleated cells.

(Submitter supplied) We report the application of single-nucleus-based sequencing technology for high-throughput profiling of transcriptome in immortazalized human myoblast KD3. By obtaining over sixty billion bases of sequence from mRNA, we generated comprehensive transcriptome profiles from KD3 undifferentiated myoblast and differentiated multi-nucleated myotube and mono-nucleated cells. We find that the data from single-nucleus RNA-seq is consistent with the transcriptome from single-cell RNA-seq. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
254 Samples
Download data: TXT
Series
Accession:
GSE79920
ID:
200079920
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