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Links from GEO DataSets

Items: 12

1.

Human somatic cells subjected to genetic reprogramming with germ line-related factors show meiotic germ cell-like features

(Submitter supplied) Results from expression arrays identified that whole cultures of i12F-reprogrammed fibroblasts clustered in a defined group and indicated a switch in their genetic expression program, as shown by the significant up-regulation of 342 genes and the down-regulation of 288 genes in treated cells compared to MOCK controls. Manually isolated i12F clumps also clustered in a defined group different to i12F and showed significant up-regulation of 329 genes (193 of them shared with i12F treatment) and down-regulation of 372 genes (225 of them shared with i12F treatment) compared to MOCK controls (Fig. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16022
20 Samples
Download data: GPR
Series
Accession:
GSE64479
ID:
200064479
2.

mRNA-Seq profiling of Stra8-deficient and wild-type testes

(Submitter supplied) We sequenced mRNA in grossly enlarged testes from 1-year-old Stra8-deficient mice, and in testes from adult male wild-type controls, to verify that Stra8-deficient testes are enriched for genes normally expressed in type A spermatogonia.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9250
6 Samples
Download data: TXT
Series
Accession:
GSE67169
ID:
200067169
3.

Human PGC commitment shares key gene dynamics to mouse, but owns a unique PRDM14 expression pattern

(Submitter supplied) The molecular mechanisms of human primordial germ cell (PGC) specification are poorly understood due to the inaccessibility of cell materials and the lack of an alternative in vitro model that enables tracking of the earliest stages of germ cell development. Here, we introduce a defined and efficient differentiation system for the induction of pre-migratory PGC-like cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
7 Samples
Download data: TXT
Series
Accession:
GSE53498
ID:
200053498
4.

Persistent Requirement and Alteration of the Key Targets of PRDM1 during Primordial Germ Cell Development in Mice

(Submitter supplied) Primordial germ cells (PGCs) are the foundation of totipotency and vital for reproduction and heredity. PGCs in mice arise from the epiblast around Embryonic Day (E) 7.0, migrate through the hindgut endoderm, and colonize and proliferate in the embryonic gonads until around E13.5 prior to their differentiation either into pro-spermatogonia or oogonia. PRDM1, a transcriptional repressor, plays an essential role in PGC specification that includes robustly repressing a somatic mesodermal program. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15907
16 Samples
Download data: TXT
Series
Accession:
GSE74094
ID:
200074094
5.

Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes

(Submitter supplied) The juvenile onset of spermatogenesis in mice is analyzed by combining cytological and transcriptomic data in a novel computational analysis, resulting in meiotic substage-specific transcriptomes and the discovery of a transcription factor network that regulates the substages of meiosis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL13112
32 Samples
Download data: TXT, XLSX
Series
Accession:
GSE72833
ID:
200072833
6.

Derivation and differentiation of haploid human embryonic stem cells [RNA-Seq 2]

(Submitter supplied) Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
2 Samples
Download data: TXT
Series
Accession:
GSE74953
ID:
200074953
7.

Derivation and differentiation of haploid human embryonic stem cells [SNP array]

(Submitter supplied) Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL21135
4 Samples
Download data: CSV, IDAT
Series
Accession:
GSE74950
ID:
200074950
8.

Derivation and differentiation of haploid human embryonic stem cells [expression array]

(Submitter supplied) Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
2 Samples
Download data: CEL
Series
Accession:
GSE74805
ID:
200074805
9.

Derivation and differentiation of haploid human embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array; Expression profiling by array; Genome variation profiling by SNP array
4 related Platforms
30 Samples
Download data: IDAT
Series
Accession:
GSE71458
ID:
200071458
10.

Derivation and differentiation of haploid human embryonic stem cells [methylation array]

(Submitter supplied) Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE71457
ID:
200071457
11.

Derivation and differentiation of haploid human embryonic stem cells [RNA-Seq 1]

(Submitter supplied) Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
15 Samples
Download data: TXT
Series
Accession:
GSE71456
ID:
200071456
12.

Hypoxia triggers meiotic fate acquisition in maize

(Submitter supplied) Evidence from confocal microscopic reconstruction of maize anther development in fertile, mac1 (excess germ cells) and msca1 (no germ cells) flowers indicates that the male germ line is multiclonal and uses the MAC1 protein to organize the somatic niche. Furthermore, we identified redox status as a determinant of germ cell fate, defining a mechanism distinct from the animal germ cell lineage. Decreasing oxygen or H2O2 increases germ cell numbers, stimulates superficial germ cell formation, and rescues germinal differentiation in msca1 flowers. more...
Organism:
Zea mays
Type:
Expression profiling by array
Platform:
GPL7444
6 Samples
Download data: TXT
Series
Accession:
GSE39101
ID:
200039101
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