GEO DataSets

(Submitter supplied) Background: Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Therefore, there is a pressing need to explore the effects of PZQ on the parasites at the molecular level and to pursue alternative and/or or synergistic drugs against schistosomiasis. Methodology: We used a custom-designed Schistosoma mansoni oligo-microarray to explore the effects of a sublethal dose of praziquantel on S. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL8606

12 Samples

Download data: TXT

(Submitter supplied) Schistosomiasis is a chronic neglected tropical disease caused by digenetic parasitic flatworms of the genus Schistosoma. The disease is estimated to affect over 206 million people, the majority of whom live in Africa where Schistosoma mansoni and Schistosoma japonicum are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

24 Samples

Download data: XLSX

(Submitter supplied) Schistosoma mansoni is one of the most common etiological agents responsible for the disease schistosomiasis. More than 200 million people suffer from this disease making it the most severe tropical disease after malaria in terms of morbidity. Praziquantel (PZQ) is the treatment of choice for schistosomiasis and has been used almost exclusively to treat the disease since the 1970s. However, while the drug is lethal for sexually mature schistosomes, it is ineffective against juveniles. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL6936

42 Samples

Download data: TXT

(Submitter supplied) Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its mechanism of action remains unknown. We have developed an assay based on the transcriptional response of S. mansoni PR-1 to heat shock to confirm that while 6 week post infection (p.i.) schistosomes are sensitive to PZQ, 4 week p.i. schistosomes are not. Further, we have used this assay to demonstrate that this sensitivity develops between days 37 and 40 p.i. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL6936

16 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of MG132 treated S. mansoni adult worms (50uM of MG132 in DMSO during 24h) vs. Non-treated S.mansoni adult worms (DMSO during 24h) Two conditions (treated vs. Non-treated) with four biological samples of treated worms (MG132 1, 2, 3 and 4) and four biological samples of non-treated worms (Control 1, 2, 3 and 4). For each sample (four treated and four non-treated) were performed two technical replicas.

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL18703

8 Samples

Download data: TXT

(Submitter supplied) We have used a Schistosoma japonicum infected murine model with in vivo sub-lethal dosages of praziquantel against adult parasites. Differential gene expression of parasites was followed between 30 minutes and 24 hours post- drug administration, using a whole transcriptome microarray platform. Differential gene expression was considered separately between parasite gender.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

20 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL8606

12 Samples

Download data: TXT

(Submitter supplied) The body’s defense against schistosome infection can take many forms. For example, upon developing acute schistosomiasis, patients often have fever coinciding with larval maturation, migration and early oviposition. As the infection becomes established, the parasite comes under oxidative stress generated by the host immune system. The most common treatment for schistosomiasis is the anti-helmenthic drug praziquantel. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL6936

16 Samples

Download data: GPR

(Submitter supplied) This study provides a detailed transcriptomic analysis of the reproductive tissues (ovary, vitelline and testes) and gastrodermis S. mansoni. The results obtained will help direct future research on the functional aspects of these specific tissues, and will allow the characterisation of currently unannotated genes in S. mansoni

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL10875

16 Samples

Download data: TXT