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Links from GEO DataSets

Items: 20

1.

Microarray analysis of skeletal muscle in PGC1α transgenic mice

(Submitter supplied) Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC1α) is a coactivator of various nuclear receptors and other transcription factors that shows increased expression in skeletal muscle during exercise. In skeletal muscle, PGC1α is considered to be involved in contractile protein function, mitochondrial function, metabolic regulation, intracellular signaling, and transcriptional responses. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
4 Samples
Download data: TXT
Series
Accession:
GSE67049
ID:
200067049
2.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE34773
ID:
200034773
3.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
4.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
5.

Peroxisome proliferator-activated receptor gamma coactivator-1alpha isoforms selectively regulate multiple splicing events on target genes.

(Submitter supplied) Endurance and resistance exercise training induce specific and profound changes in the skeletal muscle transcriptome. PGC-1a; coactivators are not only among the genes differentially induced by distinct training methods, but also participate in the ensuing signaling cascades that allow skeletal muscle to adapt to each type of exercise. While endurance training preferentially induces PGC-1a1 expression, resistance exercise activates the expression of PGC-1a2, a3, and a4. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6096
15 Samples
Download data: CEL
Series
Accession:
GSE75448
ID:
200075448
6.

Gene expression profiles from nandrolone-treated rats with denervation

(Submitter supplied) We showed that nandrolone attenuated subacute, but not acute, denervation atrophy and upregulation of MAFbx. The present study explored the molecular determinants for this time-dependent effect using microarray analysis to identify genes that were differentially regulated by administration of nandrolone for 7 days beginning either concomitantly with denervation (7 days) or 29 days later (35 days)
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE17959
ID:
200017959
7.

Expression data from quadriceps muscle of WT and ERRgamma transgenic mice

(Submitter supplied) We show that the orphan nuclear receptor ERRg is expressed at high levels in type I muscle and when transgenically expressed in anaerobic type II muscles (ERRGO mice) or cultured cells, powerfully regulates VEGF expression, angiogenesis and vascular supply in absence of exercise. ERRGO mice show increased expression of genes promoting fat metabolism, mitochondrial respiration and type I fiber specification. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE22086
ID:
200022086
8.

Microarray analysis of skeletal muscle in aged mice

(Submitter supplied) Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function, which is accompanied by reduced muscle performance. Individuals with sarcopenia often become bedridden or dependent on a wheelchair, leading to decreased quality of life. In this study, to better understand changes in skeletal muscle during sarcopenia, we performed a microarray analysis of skeletal muscle in young (13-week-old) and aged (26-month-old) mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
6 Samples
Download data: TXT
Series
Accession:
GSE125815
ID:
200125815
9.

RNA-seq analysis of Akt1-mediated muscle growth

(Submitter supplied) Background: Skeletal muscle constitutes a significant portion of total body mass and is a major regulator of systemic metabolism as it serves as the major site for glucose disposal and the main reservoir for amino acids. With aging, cachexia, starvation, and myositis, there is a preferential loss of fast glycolytic muscle fibers. We previously reported a mouse model in which a constitutively-active Akt transgene is induced to express in a subset of muscle groups leading to the hypertrophy of type IIb myofibers with an accompanying increase in strength. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: XLSX
Series
Accession:
GSE85763
ID:
200085763
10.

Expression data from a lung metastatic cell line or metastatic explants in mouse and human

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL23038 GPL23159
40 Samples
Download data: CEL
Series
Accession:
GSE99557
ID:
200099557
11.

Expression data from lung metastatic explants

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastatic explants overexpressing PGC1alpha or control, treated with phenformin to understand global gene expression changes which occur in a PGC1alpha context and under phenformin treatment. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE99556
ID:
200099556
12.

Expression data from lung metastasis

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastasis of mice injected with PGC1alpha overexpression or control cells to understand global changes that occur upon overexpression of PGC1alpha that lead to lung metastasis. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
22 Samples
Download data: CEL, TXT
Series
Accession:
GSE99555
ID:
200099555
13.

Expression data from a human lung metastatic cell line treated with siPGC1alpha or siControl

(Submitter supplied) To understand global expression changes in a knockdown of PGC1alpha (siPGC1alpha) vs control (siControl) in a lung metastatic cell line (4175) Metabolic adaptations play a key role in fuelling tumour growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that PGC-1a expression and activity are differentially regulated depending on breast cancer metastatic sites. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE99554
ID:
200099554
14.

Skeletal muscle gene expression changes with exercise mode, duration and intensity: STRRIDE study

(Submitter supplied) Skeletal muscle adapts to exercise training of various modes, intensities and durations with a programmed gene expression response. This study dissects the independent and combined effects of exercise mode, intensity and duration to identify which exercise has the most positive effects on skeletal muscle health. Full details on exercise groups can be found in: Kraus et al Med Sci Sports Exerc. 2001 Oct;33(10):1774-84 and Bateman et al Am J Cardiol. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
114 Samples
Download data: CEL, CHP
Series
Accession:
GSE48278
ID:
200048278
15.

Distinct skeletal muscle gene regulation from active contraction, passive vibration, and whole body heat stress in humans

(Submitter supplied) We used a novel approach to study the acute effect of three physiologic stressors (active contractions, vibration, and systemic heat stress) in human skeletal muscle. Three hours after the completion of a dose of physiologic stress, we sampled the soleus (contraction and vibration) or vastus lateralis (heat) muscle and developed a unique gene expression signature for each stressor. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold change), PGC-1α (5.46 fold change), and ABRA (5.98 fold change); and repressed MSTN (0.56 fold change). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
34 Samples
Download data: CEL
Series
Accession:
GSE82323
ID:
200082323
16.

Microarray analysis of transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice)

(Submitter supplied) FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle during atrophy. Previously, we created transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice). These mice weighed less than the wildtype control mice, had a reduced skeletal muscle mass. In this study, to better understand changes in skeletal muscle during atrophy, we performed a microarray analysis of skeletal muscle in wild-type control and FOXO1 Tg mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
2 Samples
Download data: TXT
Series
Accession:
GSE146919
ID:
200146919
17.

Expression data from wildtype and Tfr1 skeletal muscle KO mice

(Submitter supplied) Tfr1 is important for iron uptake in red blood cells. We deleted Tfr1 in skeletal muscle to determine the role of Tfr1 in iron uptake in skeletal muscle. We used microarrays to identify global gene changes associated with deletion of Tfr1 in skeletal muscle
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE68675
ID:
200068675
18.

Effect of Mut heterozygosity in skeletal muscle gene expression

(Submitter supplied) Branched-chain amino acids (BCAA) have emerged as predictors of type 2 diabetes (T2D). However, their potential role in the pathogenesis of insulin resistance and T2D remains unclear. By integrating data from skeletal muscle gene expression and metabolomic analyses, we demonstrate evidence for perturbation in BCAA metabolism and fatty acid oxidation in skeletal muscle from insulin-resistant humans. Experimental modulation of BCAA flux in cultured cells alters fatty acid oxidation in parallel. Furthermore, heterozygosity for the BCAA metabolic enzyme methylmalonyl-CoA mutase (MUT) alters muscle lipid metabolism in vivo, resulting in increased muscle triacylglycerol (TAG) accumulation and increased body weight after high-fat feeding. Together, our results demonstrate that impaired muscle BCAA catabolism may contribute to the development of insulin resistance by reducing fatty acid oxidation and increasing TAG accumulation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE66766
ID:
200066766
19.

Increased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice

(Submitter supplied) Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) and is even present in offspring of diabetic parents. However, molecular mediators of insulin resistance remain unclear. We find that the top-ranking gene set in expression analysis of muscle from humans with T2D and normoglycemic insulin resistant subjects with parental family history (FH+) of T2D is increased expression of actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator MKL1. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3884
Platform:
GPL570
50 Samples
Download data: CEL
Series
Accession:
GSE25462
ID:
200025462
20.
Full record GDS3884

Type 2 diabetic and insulin-resistant but normoglycemic cohorts: skeletal muscle

Analysis of quadriceps muscle from type 2 diabetes (T2D) patients and from normoglycemic but insulin-resistant subjects with a parental family history of T2D. Insulin resistance in skeletal muscle is a key phenotype of T2D. Results provide insight into the molecular basis of this insulin resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state, 2 gender sets
Platform:
GPL570
Series:
GSE25462
50 Samples
Download data: CEL
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