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Links from GEO DataSets

Items: 20

1.

Gene expression profiling of the human HepaRG hepatocellular carcinoma cell line under WNT3A stimulation.

(Submitter supplied) The aim of the study was to characterize at a molecular level (changes in mRNA level) the effects of WNT3A on the human HepaRG hepatocellular carcinoma cell line. This was adressed by culturing HepaRG cells in presence or absence of Wnt3a.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
24 Samples
Download data: TXT
Series
Accession:
GSE68633
ID:
200068633
2.

Gene Expression Profiling of Hepatocellular Carcinoma

(Submitter supplied) To identify the prognostic subtypes of hepatocellular carcinoma with potential progenitor cell origin. Keywords: disease state design
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1528
238 Samples
Download data
Series
Accession:
GSE5975
ID:
200005975
3.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL4125 GPL4124
8 Samples
Download data: TXT
Series
Accession:
GSE17733
ID:
200017733
4.

Gene expression of colon from control or VilCre;Ihhflox/flox mice

(Submitter supplied) Ihh expression is required for intestinal stem cell niche development. Loss of Ihh leads to disruption of intestinal stem cell niche, which leads to abnormal stem cell development and epithelial cell differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE18393
ID:
200018393
5.

Human HAK-1A hepatocellular carcinoma (HCC) cells: TCF-4J-overexpressing clone (under normoxia) vs. TCF-4K-overexpressing clone (under normoxia)

(Submitter supplied) The microarray gene expression analysis revealed that TCF-4 isoforms activate different downstream target genes in HCC. TCF-4J upregulated genes associated with Wnt/beta-catenin, Notch, and insulin/IGF-1/IRS1 signal transduction pathway.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
6 Samples
Download data: TXT
Series
Accession:
GSE42512
ID:
200042512
6.

Early parity-induced gene expression in total mammary epithelial cells and mammary cell subtypes in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
43 Samples
Download data: CEL
Series
Accession:
GSE40877
ID:
200040877
7.

Early parity-induced gene expression in total mammary epithelial cells in mice

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profile of total isolated mammary epithelial cells in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE40876
ID:
200040876
8.

Early parity-induced gene expression in mouse mammary cell subtypes

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profiles of stromal and various epithelial mammary cell subpopulations in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
35 Samples
Download data: CEL
Series
Accession:
GSE40875
ID:
200040875
9.

Hepatoma cell lines vs. Universal control 3

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2913
36 Samples
Download data
Series
Accession:
GSE3536
ID:
200003536
10.

Hepatoma cell lines vs. Universal control 2

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2912
18 Samples
Download data
Series
Accession:
GSE3511
ID:
200003511
11.

Hepatoma cell lines vs. Universal control

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2911
18 Samples
Download data
Series
Accession:
GSE3444
ID:
200003444
12.

TMEM88 knockdown during human embryonic stem cell cardiac differentiation

(Submitter supplied) TMEM88 is indispensable for heart development and acts in the pre-cardiac mesoderm to specify lineage commitment of the cardiovascular progenitor cell through inhibition of Wnt signaling.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5077
Platform:
GPL10558
4 Samples
Download data: TXT
Series
Accession:
GSE43805
ID:
200043805
13.
Full record GDS5077

Transmembrane protein 88 depletion effect on stem cell cardiac differentiation in vitro

Analysis of RUES2 stem cells first depleted for transmembrane protein 88 (TMEM88) and then induced to differentiate into cardiac cells. RUES cells examined at day 5 of differentitation. Results provide insight into the role of TMEM 88 in cardiac cell differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 other, 2 protocol sets
Platform:
GPL10558
Series:
GSE43805
4 Samples
Download data
14.

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFbeta signaling pathways

(Submitter supplied) Primary liver tumours include hepatocellular carcinomas (HCC), cholangiocarcinomas (CC) and a group of rare tumours exhibiting biliary and hepatocytic differentiation called combined hepatocholangiocarcinomas (cHCC-CC). To better define this latter group, we take advantage of a series of these tumours based on their morphological characteristics and we performed transcriptional analysis allowing thereafter global comparison with published data. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
30 Samples
Download data: CEL
Series
Accession:
GSE35306
ID:
200035306
15.

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma

(Submitter supplied) Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal liver development. We found a major shift in expression of Wnt and RXR-α pathway genes (up and down, respectively) coincident with the transition from hepatoblasts to hepatocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5818
Platform:
GPL7202
11 Samples
Download data: TXT
Series
Accession:
GSE65063
ID:
200065063
16.
Full record GDS5818

Normal liver developmental stages: embryonic and postnatal

Analysis of hepatoblasts, immature hepatocytes and hepatocytes from livers at different developmental timepoints (embryonic day 14, embryonic day 18, post-natal day 5, post-natal day 56). Results provide insight into molecular mechanisms underlying normal liver development.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 age, 3 cell type, 2 development stage sets
Platform:
GPL7202
Series:
GSE65063
11 Samples
Download data: TXT
17.

Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas

(Submitter supplied) Integrative whole genome and transcriptome analyses of tumor tissue, invasive border region as well as tumor-surrounding liver (SL) in 28 HCC patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
66 Samples
Download data: TXT
Series
Accession:
GSE84598
ID:
200084598
18.

Transcriptome profiling of self-renewing hESCs and multipotent mesoderm progenitor cells as a function of substrate stiffness

(Submitter supplied) We performed RNA-sequencing on human embryonic stem cell samples grown on soft (400Pa) and stiff (60kPa) hydrogels under self-renewal and differentiation conditions
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: TXT
Series
Accession:
GSE83584
ID:
200083584
19.

RNA sequencing based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers

(Submitter supplied) Hepatic progenitor cells (HPCs) are small cells with a relative large oval nucleus and a scanty cytoplasm situated in the canals of Hering, that express markers of (immature) hepatocytes and cholangiocytes. HPCs are present in large numbers in alcoholic steatohepatitis (ASH), one of the leading causes of chronic liver disease. To date, the mechanisms responsible for proliferation and differentiation of human HPCs are still poorly understood and the role of HPCs in ASH development is unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
19 Samples
Download data: CSV
Series
Accession:
GSE102683
ID:
200102683
20.

Identification of NOTCH3 unique target genes

(Submitter supplied) Notch signaling is an evolutionarily conserved signaling pathway.NOTCH3 signaling has been shown to potentially paly an important role in luminal cell fate commitment in human breast tissue by regulating unique target genes We overexpressed the intracellular domain of NOTCH1 (N1ICD) and NOTCH3 (N3ICD) receptor in nonmalignant human breast cell line, 184-hTerts
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
9 Samples
Download data: CEL
Series
Accession:
GSE127236
ID:
200127236
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