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Links from GEO DataSets

Items: 9

1.

COPD lung tissue expression

(Submitter supplied) Comparison of emphysema vs non emphysema COPD lung tissue expression
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
70 Samples
Download data: CEL
Series
Accession:
GSE69818
ID:
200069818
2.

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.

(Submitter supplied) BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. METHODS: In order to gain insights into the molecular pathways underlying progression of emphysema and explore computational strategies for identifying COPD therapeutics, we profiled gene expression in lung tissue samples obtained from regions within the same lung with varying amounts of emphysematous destruction from smokers with COPD (8 regions x 8 lungs = 64 samples). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5175 GPL13243
72 Samples
Download data: CEL
Series
Accession:
GSE27597
ID:
200027597
3.

Expression Profiling Identifies Genes Involved in Emphysema

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is a major public health problem. The aim of this study was to identify genes involved in emphysema severity in COPD patients. Gene expression profiling was performed on total RNA extracted from non-tumor lung tissue from 30 smokers with emphysema. Class comparison analysis based on gas transfer measurement was performed to identify differentially expressed genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3877
30 Samples
Download data
Series
Accession:
GSE17770
ID:
200017770
4.

Genes related to emphysema are enriched for ubiquitination pathways

(Submitter supplied) Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is emphysema; the small airway obstruction is due to inflammatory narrowing and obliteration. Despite their convergence in altered physiology, different mechanisms contribute to these processes. The relationships between gene expression and these specific phenotypes may be more revealing than comparison with lung function. We measured the ratio of alveolar surface area to lung volume (SA/V) in lung tissue from 43 smokers. Two samples from 21 subjects, in which SA/V differed by > 49 cm2/mL were profiled to select genes whose expression correlated with SA/V. The level of expression of 181 transcripts was related to SA/V ( p< 0.05). The relationship between expression of these transcripts and SA/V was tested in the 22 remaining subjects as a replication. Thirty of the 181 genes remained significantly associated with SA/V (P<0.05) and the direction of association was the same in 164/181. Pathway and network analysis revealed enrichment of genes involved in protein ubiquitination, and western blotting showed altered expression of genes involved in protein ubiquitination in obstructed individuals. These data implicate modified protein ubiquitination and degradation as a potentially important pathway in the pathogenesis of emphysema. Raw data not available for this study
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3991
42 Samples
Download data: TXT
Series
Accession:
GSE63073
ID:
200063073
5.

Induced Sputum Genes Associated With Spirometroc and Radiological Disease Severity in COPD Ex-smokers

(Submitter supplied) Induced sputum is used to sample inflammatory cells, predominantly neutrophils and macrophages, from the airways of COPD patients. Our aim was to identify candidate genes associated with the degree of airflow obstruction and the extent of emphysema by expression profiling, and then to confirm these findings for selected candidates using specific PCR and protein analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4265
Platform:
GPL570
143 Samples
Download data: CEL
Series
Accession:
GSE22148
ID:
200022148
6.
Full record GDS4265

Chronic obstructive pulmonary disease in ex-smokers: sputum

Analysis of sputum from ex-smokers with moderate (stage 2) or severe (stages 3, 4) chronic obstructive pulmonary disease (COPD). Induced sputum contains inflammatory cells, predominantly neutrophils and macrophages. Results provide insight into molecular mechanisms underlying COPD progression.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL570
Series:
GSE22148
143 Samples
Download data: CEL
DataSet
Accession:
GDS4265
ID:
4265
7.

COPD Study

(Submitter supplied) Comparison of severely emphysematous tissue removed at lung volume reduction surgery to that of normal or mildly emphysematous lung tissue resected from smokers with nodules suspicious for lung cancer. Data obtained from the 18 patients with severe emphysema and 12 patients with mild/no emphysema. Research may provide insights into the pathogenetic mechanisms involved in chronic obstructive pulmonary disease (COPD). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS737
Platform:
GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE1650
ID:
200001650
8.
Full record GDS737

Lung tissue from smokers with severe emphysema

Comparison of lung tissue from smokers with severe emphysema (removed at lung volume reduction surgery) and smokers with mild or no emphysema. Study provides insights into the pathogenesis of chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE1650
30 Samples
Download data: CEL
DataSet
Accession:
GDS737
ID:
737
9.

Gene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke

(Submitter supplied) Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE33512
ID:
200033512
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