GEO DataSets

(Submitter supplied) Analysis of the effect on dendritic cells of the injection in C57BL/6 mice of VLPs or ncRNAVLPs at gene expression level.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

11 Samples

Download data: TXT

(Submitter supplied) We have investigated the in vivo transcriptional signature in dendritic cells (DCs) from mice immunised with VLPs containing distinct classes of nucleic acid and correlated the expression patterns with the efficiency of induced T cell responses.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

12 Samples

Download data: TSV

(Submitter supplied) Nanoparticles, including virus-like particles (VLP), are attractive candidates as carriers for vaccines and drug delivery. However, little is known about how they are targeted to the immune system in vivo. Using RNA phage Qb-derived VLP (Qb-VLP) as a model antigen, we found surprisingly that antigen-specific B cells, instead of dendritic cells (DCs), were the dominant antigen presenting cells that initiate the naïve CD4 T cell activation, and were sufficient to induce T follicular helper cell development in the absence of DCs. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21273 GPL24247

12 Samples

Download data: TXT

(Submitter supplied) Nanoemulsion adjuvant affects immune gene expression in dendritic cells. Microarray was used to asses global changes in gene expression in JAWS II dendritic cells upon treatment with nanoemulsion (NE) adjuvant W805EC

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5601

Platform:

GPL1261

10 Samples

Download data: CEL, TXT

Analysis of JAWS II DCs incubated with nanoemulsion (NE) adjuvant W805EC for up to 24 hrs. W805EC is an oil-in-water emulsion with nanodroplets similar in size to many viruses infecting the nasal mucosa. Results provide insight into the molecular basis of the adjuvant activity of W805EC NE in DCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 protocol, 2 time sets

Platform:

GPL1261

Series:

GSE51804

10 Samples

Download data: CEL

(Submitter supplied) The DALIA-1 trial was designed to evaluate the safety and immunogenicity of a DC-based vaccine generated by culturing blood monocytes with GM-CSF and IFN-a. DCs were pulsed for 24 hrs with the ANRS LIPO5 peptide pool and activated for the last 6 hrs with LPS. In total, 19 asymptomatic HAART-treated patients were included in the study. Microarray samples were collected in both the treatment phase and follow-up phase of the study.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

330 Samples

Download data: TXT

(Submitter supplied) A greater understanding of the relationships between a vaccine, the immune response it induces, and protection from disease would greatly facilitate vaccine development. Modified Vaccinia virus Ankara expressing antigen 85A (MVA85A) is a novel tuberculosis (TB) vaccine designed to enhance responses induced by Bacille Calmette-Guerin (BCG). Antigen-specific interferon-γ (IFN-γ) production is greatly enhanced by MVA85A and peaks one week post-vaccination, however, the variability in response between healthy individuals is extensive. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

96 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Bone-Marrow derived mouse Dendritic Cells (bmDCs) infected with Ad-MyD88 vs. Ad-GFP or mock infected

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6524

9 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of Murine Embryonic Fibroblasts (MEFs) infected with Ad-MyD88 vs. Ad-GFP or mock infected.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6524

9 Samples

Download data: GPR

(Submitter supplied) PBMC-derived CD8 T cell activation and gene expression profiles were assessed 14 days following a single dose of a candidate live-attenuated tetravalent denge virus vaccine (DENVax). Three distinct populations of CD8+ T cells were isolated by flow cytometric sorting: 1) CD3+ CD8+ CD38- HLA-DR- T cells, 2) CD3+ CD8+ CD38+ HLA-DR+ T cells, and 3) CD3+ CD8+ CD71+ HLA-DR+ T cells

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

3 Samples

Download data: MTX, TSV

(Submitter supplied) Analysis of gene expression on day four and day six after tumor inoculation. We used microarrays to detail the global programme of gene expression underlying differences between wildtype and TLR knockout mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL