U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 12

1.

Hepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10332
4 Samples
Download data: TXT
Series
Accession:
GSE70781
ID:
200070781

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Hepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines [mock-treated]

(Submitter supplied) To facilitate accurate measurement of the relative expression levels in Hepatitis C virus infection, we carried out in four human cancer cell lines derived from Hepatic (Hec3B; human hepatoma and Huh7; human hepatocellular carcinoma) or nonhepatic (Hec1B; human endometrial and 293T;human embryonic kidney) cells. These experiments identified several genes , expression of which was altered in the same direction among them with real time PCR analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10332
4 Samples
Download data: TXT
Series
Accession:
GSE32886
ID:
200032886

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Expression data from Huh7.5.1 cells transfected with siNDRG1 or siNT

(Submitter supplied) Host cells harbor various intrinsic mechanisms to restrict viral infections as a first line of antiviral defense. Viruses have evolved various countermeasures against these antiviral mechanisms. Here we show that N-Myc Downstream-Reguated Gene 1 (NDRG1) limits productive HCV infection by inhibiting viral assembly. Interestingly, HCV infection down-regulates NDRG1 protein and mRNA expression. Loss of NDRG1 increases the size and number of lipid droplets, which are the sites of HCV assembly. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE106988
ID:
200106988

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

Whole transcriptome RNA sequencing of human cells after HCV infection (ML-1 thyroid cell line, primary thyrocytes and Huh7.5 hepatocyte cell line)

(Submitter supplied) HCV infection induce thyroid dysfunction by influencing both immune and non immune thyroid-toxic mechanisms. Similar to hepatocytes, HCV infection of thyrocytes had a significant effect on pathways of lipid and glucose metabolic processes (Figures 6A-C). These findings may suggest that HCV infection has a dual effect, inducing pathways that trigger autoimmunity as well as metabolic pathways.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
14 Samples
Download data: TXT
Series
Accession:
GSE136339
ID:
200136339

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

5.

Hepatitis C virus functionally sequesters miR-122

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL15520 GPL11154
59 Samples
Download data
Series
Accession:
GSE64680
ID:
200064680

PubMed Full text in PMC Similar studies

6.

Hepatitis C virus functionally sequesters miR-122 [miR-122 KO vs Control CLIP]

(Submitter supplied) Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5’UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL15520
7 Samples
Download data: TXT
Series
Accession:
GSE64679
ID:
200064679

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Hepatitis C virus functionally sequesters miR-122 [m15 vs Mock CLIP]

(Submitter supplied) Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5’UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
8 Samples
Download data: TXT
Series
Accession:
GSE64678
ID:
200064678

PubMed Full text in PMC Similar studies SRA Run Selector

8.

Hepatitis C virus functionally sequesters miR-122 [RNA-Seq]

(Submitter supplied) Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5’UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: TXT
Series
Accession:
GSE64677
ID:
200064677

PubMed Full text in PMC Similar studies SRA Run Selector

9.

Hepatitis C virus functionally sequesters miR-122 [LNAs vs Mock CLIP]

(Submitter supplied) Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5’UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
19 Samples
Download data: TXT
Series
Accession:
GSE64676
ID:
200064676

PubMed Full text in PMC Similar studies SRA Run Selector

10.

Hepatitis C virus functionally sequesters miR-122 [HCV vs Mock CLIP]

(Submitter supplied) Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5’UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
17 Samples
Download data: TXT
Series
Accession:
GSE64675
ID:
200064675

PubMed Full text in PMC Similar studies SRA Run Selector

11.

MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells

(Submitter supplied) Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity of the lipotrophic hepatitis C virus (HCV) is regulated by cellular lipid status. Among differentially expressed micro (mi)RNAs, we found that miR-27a was preferentially expressed in HCV-infected compared with hepatitis B virus (HBV)-infected liver. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE41737
ID:
200041737

PubMed Full text in PMC Similar studies Analyze with GEO2R

12.

Gene expression analysis of different passages and subclones of the Huh7 cell line

(Submitter supplied) Hepatitis C Virus (HCV) has a extremely narrow host cell tropism and robustly infects only very few cell lines, most importantly the human hepatoma cell line Huh7. This cell line was isolated from a 57-year old Japanese male with fulminant hepatitis. Different subclones and passages of the Huh7 cell line show up to 1000-fold differences in HCV replication efficiency (permissiveness). In this experiment, we sought to identify factors responsible for these differences by correlating gene expression from eight different uninfected Huh7 variants with their respective HCV permissiveness. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE140114
ID:
200140114

PubMed Full text in PMC Similar studies Analyze with GEO2R

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=|query=1|qty=2|blobid=MCID_66593f23e795547e5f2125b2|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center