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Links from GEO DataSets

Items: 20

1.

Human periheral blood-derived monocytes and unstimulated as well as IL-4-stimulated differentiating macrophages

(Submitter supplied) CD14+ monocytes were separated from human peripheral blood and exposed to IL-4 for 12 or 72 hours then subjected to microarray analysis We used Affymetrix miRNA1.0 microarray to obtain global miRNA expression data of human monocytes, unstimulated and IL-4-stimulated differentiating macrophages.
Organism:
synthetic construct; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
15 Samples
Download data: CEL, CSV
Series
Accession:
GSE71641
ID:
200071641
2.

The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6246 GPL8786
21 Samples
Download data: CEL, CHP
Series
Accession:
GSE71644
ID:
200071644
3.

Negative control and mir-342-3p mimics-transfected RAW264.7 mouse macrophages.

(Submitter supplied) RAW264.7 mouse macrophages were transfected with negative control and miR-342-3p mimics and subjected to microarray analysis 18 hours after the transfection. We used microarray to obtain global mRNA expression data of negative control and miR-342-3p mimics-transfected RAW264.7 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE71642
ID:
200071642
4.

MicroRNA expression in thioglycollate and alternatively activated

(Submitter supplied) Macrophage activation must be tightly controlled to prevent overzealous responses that cause self-damage. MicroRNAs have been shown to promote classical macrophage activation by blocking concomitant anti-inflammatory signals and transcription factors, but can also place restraints on activation by preventing excessive TLR-signalling. In contrast, the microRNA profile associated with alternatively activated macrophages and their role in regulating wound-healing or anti-helminthic responses has not yet been described. more...
Organism:
Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL15121
14 Samples
Download data: TXT
Series
Accession:
GSE35047
ID:
200035047
5.

Experimental identification of miR-378-3p targets by overexpression and silencing in murine NIH-3T3 fibroblasts

(Submitter supplied) MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAs and their targets. We provide data here utilizing an experimental approach to identify targets of mmu-miR-378-3p, where mmu-miR-378-3p was overexpressed and silenced in NIH-3T3 murine fibroblasts and compared to control RNA transfected cells (RISC-free siRNA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL
Series
Accession:
GSE34873
ID:
200034873
6.

The differential miRNA expression induces M2 macrophage polarization and mediates their profibrogenic effects

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL13497 GPL17107
21 Samples
Download data: TXT
Series
Accession:
GSE59349
ID:
200059349
7.

M2 cytokines alter the miRNA expression profile in macrophages

(Submitter supplied) To examine the miRNA expression profile of the profibrogenic macrophages, we compared miRNA expression in untreated versus IL-4 or IL-13-treated macrophages using miRNA microarray.IL-4 and IL-13 treatment resulted in marked changes in 18 and 19 miRNAs in macrophages, respectively.(n=3, fold changes>2, P<0.05)
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL17107
9 Samples
Download data: TXT
Series
Accession:
GSE59348
ID:
200059348
8.

mRNA expression profile in IL-4-treated macrophages transfected with miR-142-5p ASO or miR-130a-3p mimics

(Submitter supplied) To identify target genes of miR-142-5p and miR-130a-3p that are involved in M2 polarization, we examined the mRNA expression profile changes after altering miR-142-5p or miR-130a-3p expression in IL-4-treated macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
12 Samples
Download data: TXT
Series
Accession:
GSE59347
ID:
200059347
9.

miR-221-3p drives the Shift of M2-Macrophage to a Pro-Inflammatory Function by Modulating JAK3/STAT3 Signaling and is Increased in Rheumatoid Arthritis

(Submitter supplied) We performed a transcriptome analysis of M2 macrophages generated in vitro from monocytes isolated from peripheral blood of healthy donors, and studied the effect of miR-221-3p mimic transfection and stimulation with LPS.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
20 Samples
Download data: TSV
Series
Accession:
GSE133527
ID:
200133527
10.

Extensive overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte-derived differentiating macrophages

(Submitter supplied) Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) g or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: TXT
Series
Accession:
GSE100889
ID:
200100889
11.

miRNA in mouse macrophages

(Submitter supplied) By employing miRCURY LNA™ microRNA Array, we have identified a subset of 21 top miRNAs that are differentially expressed between GM-BMM and M-BMM cells
Organism:
Rattus norvegicus; Human alphaherpesvirus 2; JC polyomavirus; Murid gammaherpesvirus 4; Mus musculus; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Human alphaherpesvirus 1; Mus musculus cytomegalovirus 2; Macaca mulatta polyomavirus 1; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
4 Samples
Download data: TXT
Series
Accession:
GSE46085
ID:
200046085
12.

Regulation of Activation-Associated mRNA and MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platforms:
GPL19055 GPL14851
57 Samples
Download data
Series
Accession:
GSE60550
ID:
200060550
13.

Regulation of Activation-Associated Transcripts Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled macrophage activation-associated transcripts using TaqMan assays in a Fluidigm 48.48 Gene Expression Array to identify transcripts with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL19055
48 Samples
Download data: TXT, XLS
Series
Accession:
GSE60549
ID:
200060549
14.

Regulation of Activation-Associated MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled miRNA expression using TaqMan TLDA assays to identify miRNAs with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL14851
9 Samples
Download data: TXT
Series
Accession:
GSE60110
ID:
200060110
15.

miRCURY LNATM microRNA Array (7th Gen) profiling of monocyte-derived macrophages and monocyte-derived dendritic cells.

(Submitter supplied) To examine the miRNA changes that occur during macrophage and dendritic cell differentiation we used the miRCURY LNATM microRNA Array (7th Gen) to profile monocyte-derived macrophages and monocyte-derived dendritic cells. Of the 2046 probes present on the assay, we detected expression of ~400 (20%) miRNAs across all samples.
Organism:
Human alphaherpesvirus 2; Lymphocryptovirus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Macaca mulatta polyomavirus 1; Cytomegalovirus; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
90 Samples
Download data: TXT, XLSX
Series
Accession:
GSE60839
ID:
200060839
16.

Expression data from macrophage maturation and polarization c-Myc in alternative macrophage activation experiments

(Submitter supplied) In response to microenvironmental signals macrophages undergo different activation, indicated as classic/M1 and alternative/M2 polarization. C-Myc transcription factor could be an essential player in M2 polarization. Functional relevance of c-Myc in M2 macrophage biology is investigated by evaluating the effect of 100-58F4, on the transcriptional profile induced on human macrophages by IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE32164
ID:
200032164
17.

microRNA expression during tumor-associated macrophage (TAM) differentiation

(Submitter supplied) To further analyze the change of microRNA(miRNA) between normal peritoneal macrophage(PEC) and TAM from early tumor(12 days after 4T1 cell injection) or TAM from late tumor(21 days after 4T1 cell injection) , we employed Agilent mouse microRNA microarray Rel 12.0 as a discovery platform to identify miRNAs
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL9756
9 Samples
Download data: TXT
Series
Accession:
GSE67408
ID:
200067408
18.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
141 Samples
Download data: TSV
Series
Accession:
GSE106706
ID:
200106706
19.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TSV
Series
Accession:
GSE106705
ID:
200106705
20.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
53 Samples
Download data: TSV
Series
Accession:
GSE106704
ID:
200106704
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