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Links from GEO DataSets

Items: 20

1.

Remodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation

(Submitter supplied) The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription program of mitochondrial biogenesis and thermogenesis. In the present study, we evaluated the role of NT-PGC-1α in brown adipocyte energy metabolism by genome-wide profiling of NT-PGC-1α-responsive genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
4 Samples
Download data: TXT
Series
Accession:
GSE71774
ID:
200071774
2.

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15907
16 Samples
Download data
Series
Accession:
GSE110056
ID:
200110056
3.

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue [SAGE]

(Submitter supplied) Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many different transcription factors to regulate expression of genes involved in mitochondrial biogenesis, fatty acid oxidation, respiration and thermogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15907
12 Samples
Download data: TXT
Series
Accession:
GSE110055
ID:
200110055
4.

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue [ChIP-Seq]

(Submitter supplied) Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many different transcription factors to regulate expression of genes involved in mitochondrial biogenesis, fatty acid oxidation, respiration and thermogenesis. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15907
4 Samples
Download data: BEDGRAPH
Series
Accession:
GSE110053
ID:
200110053
5.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

(Submitter supplied) Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2123
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5042
ID:
200005042
6.

Expression of the brown fat thermogenic gene program requires PGC-1alpha

(Submitter supplied) To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severly reduced the induction of thermogenic genes. In order to assess the specific requirement for PGC-1α in the global transcriptional response to cAMP, we used Affymetrix arrays to compare the sets of genes induced in response to a 4 hr dbcAMP treatment in differentiated wt and KO cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2149
Platform:
GPL1261
8 Samples
Download data
Series
Accession:
GSE5041
ID:
200005041
7.
Full record GDS2149

PGC-1alpha null brown adipocyte response to cAMP

Analysis of PGC-1alpha null brown adipocytes treated with cAMP for 4 hours. PGC-1alpha is required for the thermogenic function of brown fat cells, and cAMP plays a role in thermogenesis. Results provide insight into the role of PGC-1alpha in the global transcriptional response to cAMP.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5041
8 Samples
Download data
DataSet
Accession:
GDS2149
ID:
2149
8.
Full record GDS2123

Brown fat cell response to PGC-1alpha and PGC-1beta deficiency

Analysis of brown fat cells lacking PGC-1alpha or both PGC-1alpha and PGC-1beta. PGC-1alpha is required for the thermogenic function of brown fat cells, and PGC-1beta is the closest homolog of PGC-1alpha. Results provide insight into the specific roles of PGC-1alpha and PGC-1beta in brown fat cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5042
6 Samples
Download data
DataSet
Accession:
GDS2123
ID:
2123
9.

Expression data from white adipose tissue of Perilipin A transgenic mice

(Submitter supplied) Perilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Adipocyte specific overexpression of PeriA caused resistance to diet-induced obesity and resulted in improved insulin sensitivity. In order to better understand the biological basis for this observed phenotype we performed DNA microarray analysis on white adipose tissue (WAT) from PeriA transgenic (Tg) and control wildtype (WT) mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE21754
ID:
200021754
10.

Sex-dependent effects of Siah2 on brown adipose tissue whitening and inflammation with a high fat diet

(Submitter supplied) The goal of this experiment was to examine the sex-dependent effect of Siah2 in brown adipose tissue
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6885 GPL6887
18 Samples
Download data: TXT
Series
Accession:
GSE123990
ID:
200123990
11.

Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057 GPL13112
21 Samples
Download data: BW
Series
Accession:
GSE83928
ID:
200083928
12.

Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge [RNA-Seq]

(Submitter supplied) Brown adipose tissue (BAT) is a thermogenic organ that requires Uncoupling Protein 1 (UCP1) to dissipate chemical energy as heat, to defend core body temperature against hypothermia, and counteract obesity and metabolic diseases1. However, the transcriptional mechanism ensuring BAT thermogenic capacity for survival prior to environmental cold is unknown. Here we show histone deacetylase 3 (HDAC3) is a required transcriptional regulator of BAT enhancers to ensure thermogenic aptitude and survival. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: XLSX
Series
Accession:
GSE83927
ID:
200083927
13.

Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge [ChIP-Seq, GRO-Seq]

(Submitter supplied) Brown adipose tissue (BAT) is a thermogenic organ that requires Uncoupling Protein 1 (UCP1) to dissipate chemical energy as heat, to defend core body temperature against hypothermia, and counteract obesity and metabolic diseases1. However, the transcriptional mechanism ensuring BAT thermogenic capacity for survival prior to environmental cold is unknown. Here we show histone deacetylase 3 (HDAC3) is a required transcriptional regulator of BAT enhancers to ensure thermogenic aptitude and survival. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL17021 GPL13112 GPL19057
15 Samples
Download data: BW
14.

Transcriptome analysis in adipose tissues of BAF60a knockout mice

(Submitter supplied) Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. BAF60a serves an indispensable role in cold-induced thermogenesis in brown fat. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
12 Samples
Download data: CEL
Series
Accession:
GSE145498
ID:
200145498
15.

BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

(Submitter supplied) Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL21103
12 Samples
Download data: BW, CSV
Series
Accession:
GSE128747
ID:
200128747
16.

Brown versus white tissue adipose selective genes

(Submitter supplied) The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Keywords: tissue comparison from mice
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2813
Platform:
GPL1261
6 Samples
Download data: CEL, CHP, DCP, TXT
Series
Accession:
GSE8044
ID:
200008044
17.
Full record GDS2813

Brown and white adipose tissues

Comparison of brown and white adipose tissues. Brown fat cells are specialized to dissipate energy and can counteract obesity. Results provide insight into the molecular mechanisms controlling brown fat cell determination.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL1261
Series:
GSE8044
6 Samples
Download data: CEL, CHP, DCP, TXT
18.

RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

(Submitter supplied) RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE78143
ID:
200078143
19.

Gene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes

(Submitter supplied) Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4851
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE40280
ID:
200040280
20.
Full record GDS4851

TRPV4 depletion effect on adipocyte cell line

Analysis of 3T3-F442A adipocytes depleted for transient receptor potential vanilloid 4 (TRPV4). TRPV4 is a cation channel. Results provide insight into the function of TRPV4 in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL8321
Series:
GSE40280
4 Samples
Download data: CEL
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