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Links from GEO DataSets

Items: 20

1.

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

(Submitter supplied) The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed immunoproteasome function for polarization of alveolar macrophages which are highly specialized tissue macrophages of the alveolar surface of the lung. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE72000
ID:
200072000
2.

Gene expression profiling of mouse macrophages following long noncoding RNA Malat1 knockdown

(Submitter supplied) We applied next-generation sequencing to investigate the gene expression profiles in mouse bone-marrow derived macrophages with or without long noncoding RNA-Malat1 knockdown. We identified a number of differentially regulated genes in cells with Malat1 knockdown.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TXT
Series
Accession:
GSE106913
ID:
200106913
3.

RNA-Seq analysis of alveolar macrophages from normal and fibrotic mouse lungs

(Submitter supplied) We performed gene expression profiling of alveolar macrophages from mice that were intratracheally instilled with saline or bleomycin. We identified a number of differentially expressed genes in the two groups of cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: TXT
Series
Accession:
GSE98468
ID:
200098468
4.

Transcript dynamics in classically and alternatively activated macrophages

(Submitter supplied) Using RNA-seq, we have reported that signaling crosstalk among IFN-γ and LPS is integrated at the level of transcriptome and have associated with TFs and TcoFs changes. In addition, we also argue that the transcriptional differences between BMDMs and RAW264.7 macrophage cell line as well as IL-4 and IL-13 on M2 macrophages activation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
25 Samples
Download data: TAB
Series
Accession:
GSE103958
ID:
200103958
5.

Gene expression profiles from murine BALB/c macrophages at the extremes of the M1 and M2 polarized phenotypes

(Submitter supplied) Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M1 and M2 polarized phenotypes. The aim of the present study was to screen for differentially expressed genes (DEGs) that were associated with macrophage polarization. The transcription profiles of three M1 and three M2 samples were obtained using microarray analysis. Based on the threshold of fold-change >2.0 and a p-value < 0.05, we screened a total of 1,253 DEGs, of which 696 were upregulated and 557 downregulated in M1 macrophages compared to that in M2 macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20939
6 Samples
Download data: TXT
Series
Accession:
GSE81922
ID:
200081922
6.

Development, phenotype and function of a distinct macrophage subpopulation induced by IL-23

(Submitter supplied) Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses. Classically, macrophages are categorized into two different subsets named inflammatory M1 and anti-inflammatory M2 macrophages. We herein identified a unique pathogenic macrophage subpopulation, named M17, driven by IL-23 with a distinct gene expression profile including cytokines and membrane molecules. In contrast to M1 and M2-polarized macrophages, M17 macrophages express high levels of CXCR5 on the cell surface and produce large amounts of IL-17A, IL-22 and IFN-γ. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: TXT, XLSX
Series
Accession:
GSE102274
ID:
200102274
7.

Role of Gq/11 and G12/13 signalling in Type II alveolar epithelial cells

(Submitter supplied) We have used microarrays to identify individual genes and pathways regulated by Gq/11 or G12/13 signalling in type II alveolar epithelial cells isolated from the lungs of knockout mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE87842
ID:
200087842
8.

Expression Data from murine control and IL6ralpha-deficient macrophages stimulated with Interleukin-6

(Submitter supplied) IL-6 induces IL4ralpha expression in macrophages. This mechanism is necessary to promote macrophage polarization towards an M2-phenotype and is crucial to limit the inflammatory response both upon obesity and LPS-endotoxemia. In this dataset, we include the expression data obtained from primary murine bone marrow-derived macrophages from control and IL6ralpha-deficient macrophages (n=4vs4) stimulated with interleukin-6 (IL-6)
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5383
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE47426
ID:
200047426
9.
Full record GDS5383

Interleukin-6 effect on interleukin-6 receptor α-deficient macrophages

Analysis of interleukin-6 receptor α-deficient bone marrow-derived macrophages (BMDMs) stimulated with interleukin-6 (IL-6). Cytokine IL-6 is linked to obesity, and macrophages are key mediators of obesity-associated inflammation. Results provide insight into the role of IL-6 in macrophages.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE47426
8 Samples
Download data: CEL
10.

STAT2 Signaling Regulates Macrophage Phenotype during Influenza and Bacterial Super-infection

(Submitter supplied) Influenza is the common respiratory problem that infects between 5-20% of the US population and results in 30,000 deaths annually. A primary cause of the influenza-associated death is due to secondary bacterial pneumonia. In this study, we investigated the role of STAT2 signaling during influenza and influenza-bacterial super-infection in mice. Herein, we demonstrate that STAT2 signaling is required for viral control, regulation of inflammation, and limiting mortality during influenza single infection. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: DIFF
Series
Accession:
GSE119029
ID:
200119029
11.

Single-cell RNA sequencing reveals non-canonical brain macrophage activation states in murine neurotrauma

(Submitter supplied) Background: Macrophage polarization programs, commonly referred to as “classical” and “alternative” activation, are widely considered as distinct states that are exclusive of one another, and are associated with different functions such as inflammation and wound healing, respectively. In a number of disease contexts, such as traumatic brain injury (TBI), macrophage polarization influences the extent of pathogenesis, and efforts are underway to eliminate pathogenic subsets. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
45 Samples
Download data: TXT
Series
Accession:
GSE79510
ID:
200079510
12.

Metabolic reprogramming of macrophage polarization by creatine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL23479 GPL13112
12 Samples
Download data: BED, TXT, WIG
Series
Accession:
GSE110456
ID:
200110456
13.

Metabolic reprogramming of macrophage polarization by creatine [ATAC-seq]

(Submitter supplied) We found that the creatine metabolic pathway was differentially regulated under M1 versus M2 polarizing conditions. In return, creatine could suppress M1 by blocking STAT1 tyrosine phosphorylation while promote M2 by sustaining chromatin accessibility of specific gene loci.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: BED, WIG
Series
Accession:
GSE110403
ID:
200110403
14.

Metabolic reprogramming of macrophage polarization by creatine [RNA-seq]

(Submitter supplied) We found that the creatine metabolic pathway was differentially regulated under M1 versus M2 polarizing conditions. In return, creatine could suppress M1 by blocking STAT1 tyrosine phosphorylation while promote M2 by sustaining chromatin accessibility of specific gene loci.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
8 Samples
Download data: TXT
Series
Accession:
GSE110395
ID:
200110395
15.

mRNA expression data from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6246 GPL11533
84 Samples
Download data: CEL
Series
Accession:
GSE47551
ID:
200047551
16.

mRNA expression data from whole trachea dissected from either wild-type mice or Scnn1b-Tg mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47550
ID:
200047550
17.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; and Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84. Briefly, overexpression of the Scnn1b transgene in airway Club cells leads to hyperabsorption of sodium from the airway surface liquid, dehydrated airway surface liquid and mucus, and reduced mucus clearance associated with accumulation of mucus plugs/plaques. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
36 Samples
Download data: CEL
Series
Accession:
GSE47548
ID:
200047548
18.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration [left lobe only]

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47546
ID:
200047546
19.

Expression data from lipopolysaccharide treated and untreated equine alveolar macrophages and basal comparison with peritoneal macrophages

(Submitter supplied) Alveolar macrophages are the first line of defense against pathogens in the lungs of all mammalian species and therefore may constitute an appropriate therapeutic target cell in the treatment and prevention of opportunistic airway infections. Analysis of alveolar macrophages from several species has revealed a unique cellular phenotype and transcriptome, presumably linked to their distinct airway environment and function in host defense. more...
Organism:
Equus caballus
Type:
Expression profiling by array
Platforms:
GPL18123 GPL20334
13 Samples
Download data: CEL
Series
Accession:
GSE69871
ID:
200069871
20.

Comparison of gene expression in thyrocytes between wildtype and thyroid-specific IFNg transgenic mice

(Submitter supplied) Hürthle cells are found in thyroid tumors and autoimmunity, and have a unique appearance characterized by swollen eosinophilic cytoplasm filled with mitochondria and hyperchromatic nucleus. The pathogenesis of Hürthle cells remains unknown. We have generated transgenic mice expressing IFNg specifically in thyroid gland, and shown they develop changes in the thyroid follicular cell that resemble those of the human Hürthle cell. more...
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL8251
2 Samples
Download data
Series
Accession:
GSE15114
ID:
200015114
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