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Links from GEO DataSets

Items: 20

1.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Rattus norvegicus; Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL18609 GPL18615
340 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE72088
ID:
200072088
2.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)

(Submitter supplied) The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has been proven successful in improving the prediction of genotoxicity in vivo and the understanding of underlying mechanisms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18615
184 Samples
Download data: CEL
Series
Accession:
GSE72081
ID:
200072081
3.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)

(Submitter supplied) The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has been proven successful in improving the prediction of genotoxicity in vivo and the understanding of underlying mechanisms. more...
Organism:
Mus musculus; Homo sapiens; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL18609
156 Samples
Download data: GPR, TXT
Series
Accession:
GSE72014
ID:
200072014
4.

Evaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL18609 GPL18615
120 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE57132
ID:
200057132
5.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]

(Submitter supplied) The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18615
60 Samples
Download data: CEL
Series
Accession:
GSE57129
ID:
200057129
6.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]

(Submitter supplied) The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL18609
60 Samples
Download data: GPR, TXT
Series
Accession:
GSE57082
ID:
200057082
7.

MicroRNA and mRNA biomarkers for short-term in vivo genotoxic and non-genotoxic carcinogen classification

(Submitter supplied) Many innovative techniques and scientific improvements are available to tackle societal concerns, like public health safety and confining the risk of cancerous exposure to chemicals, but have not been thoroughly tested and implicated yet. We investigated if microRNA and mRNA transcription profiles can be implemented in a short-term carcinogen classifier assay. Our study is additionally focusing on the drawbacks of present-day carcinogen screening strategies and also aims to contribute to a more ethical approach towards animal use and welfare within risk assessment. more...
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL16560
68 Samples
Download data: TXT
Series
Accession:
GSE43847
ID:
200043847
8.

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

(Submitter supplied) At present, substantial efforts are focused on the development of in vitro assays coupled with ”omics” technologies for the identification of carcinogenic substances as an alternative to the classical 2-year rodent carcinogenicity bioassay. A prerequisite for the eventual regulatory acceptance of such assays, however, is the in vivo relevance of the observed in vitro findings.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
72 Samples
Download data: CEL
Series
Accession:
GSE36524
ID:
200036524
9.

Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(Submitter supplied) For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared.
Organism:
Homo sapiens; Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL13916 GPL15933
548 Samples
Download data: CEL
Series
Accession:
GSE40117
ID:
200040117
10.

Gene expression profiling to recognize specific features of (non-) genotoxic carcinogens

(Submitter supplied) The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demon­strated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17198
88 Samples
Download data: CEL
Series
Accession:
GSE47345
ID:
200047345
11.

Gene expression profiling to recognize specific features of non-genotoxic carcinogens

(Submitter supplied) The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demonstrated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15125
111 Samples
Download data: CEL, TXT
Series
Accession:
GSE44088
ID:
200044088
12.

Trancriptional profiling of rat liver after short-term (up tp 14 days) administration of carcinogenic and non-carcinogenic chemicals

(Submitter supplied) The carcinogenic potential of chemicals is currently evaluated with rodent life-time bioassays, which are time consuming, and expensive with respect to cost, number of animals and amount of compound required. Since the results of these 2-year bioassays are not known until quite late during development of new chemical entities, and since the short-term test battery to test for genotoxicity, a characteristic of genotoxic carcinogens, is hampered by low specificity, the identification of early biomarkers for carcinogenicity would be a big step forward. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
421 Samples
Download data: CEL
Series
Accession:
GSE68110
ID:
200068110
13.

Transcriptional profiling of microRNAs after short-term exposure of CD1-mice to carcinogenic and non-carcinogenic chemicals

(Submitter supplied) Assessing the carcinogenic potential of drug candidates is a costly procedure which requires the life-long treatment of rodents at different dose levels. A promising approach, which may to a certain degree reduce the need for animal studies in the future is toxicogenomics. The idea is to employ microarray platforms for the genome-wide expression profiling of compounds, which may facilitate the discovery of biomarker genes and provide insights in molecular mechanisms. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL13493
224 Samples
Download data: TXT
Series
Accession:
GSE67943
ID:
200067943
14.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array; Protein profiling by protein array
Platforms:
GPL14889 GPL17787 GPL341
189 Samples
Download data: CEL, CSV, TXT
Series
Accession:
GSE53085
ID:
200053085
15.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (protein)

(Submitter supplied) In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. more...
Organism:
Mus musculus; Rattus norvegicus
Type:
Protein profiling by protein array
Platform:
GPL17787
63 Samples
Download data: CSV
Series
Accession:
GSE53084
ID:
200053084
16.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (miRNA)

(Submitter supplied) In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL14889
63 Samples
Download data: TXT
Series
Accession:
GSE53083
ID:
200053083
17.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)

(Submitter supplied) In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
63 Samples
Download data: CEL
Series
Accession:
GSE53082
ID:
200053082
18.

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.

(Submitter supplied) Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alternative test are urgently needed. Non-genotoxic carcinogens, however, act through different modes of action, which complicates the development of such an assay. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15125
71 Samples
Download data: CEL, TXT
Series
Accession:
GSE35058
ID:
200035058
19.

Expression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens.

(Submitter supplied) Assessing the carcinogenic potential of drug candidates is a costly procedure which requires the life-long treatment of rodents at different dose levels. A promising approach, which may to a certain degree reduce the need for animal studies in the future is toxicogenomics. The idea is to employ microarray platforms for the genome-wide expression profiling of compounds, which may facilitate the discovery of biomarker genes and provide insights in molecular mechanisms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
450 Samples
Download data: CEL
Series
Accession:
GSE44783
ID:
200044783
20.

Expression Profiles of HepG2 cells treated with genotoxic and non-genotoxic agents

(Submitter supplied) The lack of accurate in vitro assays for predicting in vivo toxicity of chemicals together with new legislations demanding replacement and reduction of animal testing has triggered the development of alternative methods. This study aimed at developing a transcriptomics-based in vitro prediction assay for in vivo genotoxicity. The transcriptomics changes induced in the human liver cell line HepG2 by 34 compounds after treatment for 12h, 24h and 48h were used for the selection of gene-sets that can discriminate between in vivo genotoxins (GTX) and in vivo non-genotoxins (NGTX). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9101
560 Samples
Download data: CEL
Series
Accession:
GSE28878
ID:
200028878
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