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Links from GEO DataSets

Items: 20

1.

Global analysis of genes regulated by canonical Wnt pathway

(Submitter supplied) Up-regulation of canonical Wnt signaling has been implicated in liver fibrosis and cancer. To determine canonical Wnt target genes potentially implicated in these diseases, we performed microarray analysis of culture-activated rat hepatic stellate cells (HSCs) treated with canonical Wnt inhibitors, DKK-1, ICG-001, or FJ9.
Organism:
Rattus norvegicus; Rattus norvegicus albus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE76330
ID:
200076330
2.

LRP5 and LRP6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells

(Submitter supplied) The canonical Wnt signaling pathway has been demonstrated as a critical role in the self-renewal, proliferation and differentiation of Hematopoietic Stem Cells (HSCs), but the functions are indeterminacy in adult HSCs since the different experimental systems using gain- or loss- functions mice models. Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6) are important co-receptors in the canonical Wnt/β-catenin pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
5 Samples
Download data: TXT
Series
Accession:
GSE122635
ID:
200122635
3.

Unique MicroRNA Expression Signature Predicts Survival, Metastases and Recurrence of HCC

(Submitter supplied) In this study we investigated the miRNA expression profile of Hepatocellular carcinoma (HCC) specimens from radical resection. We developed a unique 20 miRNA signature that could significantly distinguish HCC venous metastasis from metastasis-free HCC. In contrast to HCC staging systems, this signature was capable of predicting survival and recurrence of HCC patients with multinodular or solitary tumors, including those with early-stage disease. more...
Organism:
Mus musculus; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL4700
482 Samples
Download data: GPR, TXT, XLS
Series
Accession:
GSE6857
ID:
200006857
4.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18802
16 Samples
Download data: CEL
Series
Accession:
GSE107374
ID:
200107374
5.

Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/β-catenin Signaling

(Submitter supplied) Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/β-catenin signaling is likely to be a major effector of its tumor-promoting role.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: XLSX
Series
Accession:
GSE101061
ID:
200101061
6.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL4125 GPL4124
8 Samples
Download data: TXT
Series
Accession:
GSE17733
ID:
200017733
7.

Induction of hepatocellular carcinoma through activation of stromal cells in Pdgf-c transgenic mice

(Submitter supplied) Liver cirrhosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes patients to tumorigenesis are not well understood. Transgenic mice expressing platelet-derived growth factor C (Pdgf-c) under the control of the albumin promoter provide a unique animal model that mimics the step-wise disease progression in humans from fibrosis to HCC. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5320
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE38199
ID:
200038199
8.
Full record GDS5320

Platelet-derived growth factor C transgenic model of hepatocellular carcinoma: liver stromal cells

Analysis of liver stroma from 8.8-week-old PDGF-C transgenics wherein PDGF-C is ectopically expressed in hepatocytes. The transgenics develop progressive liver fibrosis with a high incidence of HCC. Results provide insight into PDGF-C-driven molecular changes in liver stroma contributing to HCC.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE38199
16 Samples
Download data: CEL
9.

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

(Submitter supplied) Background & Aims: Cirrhosis and chronic inflammation precede development of hepatocellular carcinoma (HCC) in approximately 80% of cases. We investigated immune-related gene expression patterns in liver tissues surrounding early-stage HCCs and chemopreventive agents that might alter these patterns to prevent liver tumorigenesis. Methods: We analyzed gene expression profiles of non-tumor liver tissues from 392 patients with early-stage HCC (training set, n=167 and validation set, n=225) and liver tissue from patients with cirrhosis without HCC (n=216, controls) to identify changes in expression of genes that regulate the immune response that could contribute to hepatocarcinogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21382
22 Samples
Download data: CEL
Series
Accession:
GSE125975
ID:
200125975
10.

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(Submitter supplied) Genome-wide expression analysis of 228 hepatocellular carcinoma and 168 cirrhotic samples as part of a integrated study of gene expression and DNA-methylation de-regulation in patients with hepatocellular carcinoma Analysis of whole-genome transcriptome changes in human samples from hepatocellular carcinoma patients
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
396 Samples
Download data: CEL
Series
Accession:
GSE63898
ID:
200063898
11.

Gene-expression profiles of hepatitis C-related, early-stage liver cirrhosis

(Submitter supplied) BACKGROUND & AIMS: Cirrhosis affects 1% to 2% of the world population and is the major risk factor for hepatocellular carcinoma (HCC). Hepatitis C cirrhosis-related HCC is the most rapidly increasing cause of cancer death in the United States. Noninvasive methods have been developed to identify patients with asymptomatic early-stage cirrhosis, increasing the burden of HCC surveillance, but biomarkers are needed to identify patients with cirrhosis who are most in need of surveillance. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8432
216 Samples
Download data: TXT
Series
Accession:
GSE15654
ID:
200015654
12.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
387 Samples
Download data: TXT
Series
Accession:
GSE10143
ID:
200010143
13.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Validation Set)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
225 Samples
Download data: TXT
Series
Accession:
GSE10142
ID:
200010142
14.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, HCC)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
80 Samples
Download data: TXT, XLS
Series
Accession:
GSE10141
ID:
200010141
15.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, Liver)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
82 Samples
Download data: TXT
Series
Accession:
GSE10140
ID:
200010140
16.

FGFR3-shRNA induced transcriptional changes in RT112 bladder cancer cells

(Submitter supplied) Aberrant activation of FGFR3 via overexpression or mutation is a frequent feature of bladder cancer; however, its molecular and cellular consequences and functional relevance to carcinogenesis are not well understood. In this study with a bladder carcinoma cell line expressing inducible FGFR3 shRNAs, we sought to identiy transcriptional targets of FGFR3 and investigate their contribution to bladder cancer development.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4454
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE41035
ID:
200041035
17.
Full record GDS4454

Fibroblast growth factor receptor 3 depletion effect on bladder cancer cell line RT112

Analysis of bladder cancer cell line RT112 subjected to doxycycline-inducible, shRNA knockdown of FGFR3. Knockdown of FGFR3 in RT112 cells significantly attenuates tumor growth in vitro and in vivo. Results provide insight into the molecular mechanisms underlying FGFR3-driven bladder cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 genotype/variation, 2 protocol sets
Platform:
GPL570
Series:
GSE41035
24 Samples
Download data: CEL
DataSet
Accession:
GDS4454
ID:
4454
18.

Expression data from murine hepatic stellate cells

(Submitter supplied) Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the cAMP-response element-binding protein-binding protein (CBP)/β-catenin interaction, on liver fibrosis were examined using carbon tetrachloride (CCl4)- or bile duct ligation (BDL)-induced mouse liver fibrosis models. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE73603
ID:
200073603
19.

A comparative miRNA/mRNA analysis in distinct murine liver cancer models reveals miR-193a-5p and NUSAP1 as therapeutic targets in HCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Expression profiling by RT-PCR
Platforms:
GPL11533 GPL22525
69 Samples
Download data: CEL, TXT
Series
Accession:
GSE102418
ID:
200102418
20.

A comparative miRNA/mRNA analysis in distinct murine liver cancer models reveals miR-193a-5p and NUSAP1 as therapeutic targets in HCC [miRNA]

(Submitter supplied) BACKGROUND & AIMS: We performed an integrated analysis to identify microRNAs (miRNAs) and mRNAs with altered expression in liver tumors from 3 mouse models of hepatocellular carcinoma (HCC) and human tumor tissues. METHODS: We analyzed miRNA and mRNA expression profiles of liver tissues from mice with diethylnitrosamine-induced hepatocarcinogenesis, conditional expression of lymphotoxin alpha and lymphotoxin beta , or inducible expression of a Myc transgene (Tet-O-Myc mice), as well as male C57BL/6 mice (controls). more...
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by RT-PCR
Platform:
GPL22525
34 Samples
Download data: TXT
Series
Accession:
GSE102417
ID:
200102417
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