GEO DataSets

(Submitter supplied) Background: HIV infection is associated with impaired gas transfer in the lung as indicated by a low diffusing capacity (DLCO). Mechanisms for reduced DLCO in the setting of HIV infection are not well understood. We hypothesized that HIV-associated gas exchange impairment is indicative of system-wide perturbations that could be reflected by alterations in peripheral blood gene expression. Methods: A total of 40 HIV-infected (HIV+) and uninfected (HIV-) men with preserved versus reduced DLCO were selected from a larger cohort study of lung function. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

39 Samples

Download data: CEL

(Submitter supplied) Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. Previous studies have been hampered by difficulties in obtaining early specimens. We studied 29 HIV infected subjects 1 month from presentation and 46 contemporaneous uninfected controls. We used RNA-seq to examine circulating immune cells to describe in detail the profound gene dysregulation observed in early HIV infection. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

74 Samples

Download data: CSV

(Submitter supplied) Analysis of HIV-associated neurocognitive disorder (HAND) in peripheral monocytes at the gene expression level. The hypothesis tested in the present study was that monocyte gene expression would be predictive of HAND. Results provide information of the associations between monocytes and global neurocognitive function.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

248 Samples

Download data: TXT