GEO DataSets

(Submitter supplied) We report differential gene expression with tissue-specific signatures in tick cell lines infected with Anaplasma phagocytophilum - transcriptional response to infection of I. scapularis ISE6 cells resembled that of tick hemocytes while the response in I. ricinus IRE/CTVM20 cells resembles that of tick midguts.

Organism:

Ixodes ricinus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21340

4 Samples

Download data: FPKM_TRACKING

(Submitter supplied) There has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis, and human anaplasmosis. The primary tick vectors implicated are hard ticks of the Ixodes genera. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. more...

Organism:

Ixodes ricinus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21340

6 Samples

Download data: FPKM_TRACKING

(Submitter supplied) Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcriptome and proteome in response to A. phagocytophilum infection. However, in the post-genomic era, the integration of omics datasets through a systems biology approach allows network-based analyses to describe the complexity and functionality of biological systems such as host-pathogen interactions and the discovery of new targets for prevention and control of infectious diseases. more...

Organism:

Ixodes scapularis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18496

4 Samples

Download data: GTF

(Submitter supplied) Ticks are blood feeding arthropod ectoparasites that transmit pathogens, which cause diseases in humans and animals worldwide. In the past ten decades, the continuous human exploitation of environmental resources and the increase in human outdoor activities has promoted contact with arthropod vectors normally present in the wild, resulting in increased transmission of vector-borne pathogens. In addition, vector populations are expanding in response to climate change and human interventions that impact reservoir host movement and human exposure to infected vectors. more...

Organism:

Ixodes scapularis

Type:

Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL21603

4 Samples

Download data: GTF

(Submitter supplied) Ixodes species ticks are competent vectors of tick-borne viruses including tick-borne encephalitis and Powassan encephalitis.  Tick saliva has been shown to facilitate and enhance viral infection.  This likely occurs by saliva-mediated modulation of host responses into patterns favorable for viral infection and dissemination.  Because of the rapid kinetics of tick-borne viral transmission, this modulation must occur as early as tick attachment and initiation of feeding.  In this study, the gene expression profile of cutaneous bite-site lesions created by uninfected ticks were analyzed at 1, 3, 6, and 12 hours after Ixodes scapularis nymphal tick attachment to discover host pathways or responses potentially important in tick-borne viral establishment.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4357

Platform:

GPL8321

15 Samples

Download data: CEL

Analysis of ear bite-site biopsies from BALB/c hosts up to 12 hours after post nymphal tick infestation. Tick saliva facilitates and enhances viral infection. Results provide insight into immunomodulation at tick-host interface induced by tick saliva that facilitates tick-born virus transmission.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 stress, 5 time sets

Platform:

GPL8321

Series:

GSE39100

15 Samples

Download data: CEL