Similar studies for GEO DataSets (Select 200078911) - GEO DataSets

(Submitter supplied) Normal human hepatocytes and 3 different HCC cell lines have been analyzed for the global expression of long non coding RNA (lncRNA). Total RNA was extracted from each sample using RNeasy Kit (Qiagen) according to the manufacturer’s instructions. RNA quality was assessed by Nanodrop ND-1000 and Bioanalyser2100. DNA microarray The Human Long Non-coding RNA Array was manufactured by Roche NimbleGen. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL11269
4 Samples

Download data: PAIR

Series

Accession:: GSE25859

ID:: 200025859

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001073744.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18802
16 Samples

Download data: CEL

Series

Accession:: GSE107374

ID:: 200107374

Select item 2001010615.

Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/β-catenin Signaling

(Submitter supplied) Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/β-catenin signaling is likely to be a major effector of its tumor-promoting role.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: XLSX

Series

Accession:: GSE101061

ID:: 200101061

PubMed Similar studies SRA Run Selector

Select item 2000177336.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL4125 GPL4124
8 Samples

Download data: TXT

Series

Accession:: GSE17733

ID:: 200017733

Select item 2002397777.

MeDIP-seq profiles of mouse ApcDHep hepatocytes at day 6 vs wt hepatocytes

(Submitter supplied) We analyzed the level of DNA methylation by MeDIPseq in hepatocytes isolated by collagenase perfusion from Apclox/loxlivers, six days after injection of 2mg tamoxifen vs wt hepatocytes. Our aims was to study the impact of the beta-catenin on DNA methylation during the early steps of liver tumorigenesis

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: BW

Series

Accession:: GSE239777

ID:: 200239777

PubMed Similar studies

Select item 2000685948.

Hyperexpression of transcribed noncoding RNA containing ultraconserved genomic regions 8 promotes bladder tumorigenesis

(Submitter supplied) Ultraconserved regions (UCRs) are segments of the human genome located in both intragenic and intergenic regions that are highly conserved in orthologous regions of the human, rat, and mouse genomes. Their transcriptional products, called T-UCRs, compose a new category of long noncoding RNA (lncRNAs). Most importantly, recent data suggests that T-UCRs are altered at the transcriptional level in human tumorigenesis and the aberrant T-UCRs expression profiles can be used to differentiate human cancer types. more...

Organism:: Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL20120
53 Samples

Download data: GPR

Series

Accession:: GSE68594

ID:: 200068594

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002119309.

chromatin openin profiles in mouse ApcDeltaHep or wt hepatocytes

(Submitter supplied) We analyzed chromatin opening in hepatocytes isolated from ApcDeletaHep livers or wt by ATAC-seq. We thus explore how an aberrant activation of beta-catenin signaling modifies chromatin structure in hepatocytes

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BW

Series

Accession:: GSE211930

ID:: 200211930

PubMed Similar studies

Select item 20021048210.

Kinetic RNA profiles in mouse ApcDeltaHep hepatocytes at day 6, 15 and 21 after activation vs wt hepatocytes

(Submitter supplied) We analyzed the expression of RNAs in hepatocytes isolated from Apclox/lox livers, after injection of adenovirus Ad5-Cre-GFP and hepatocyte sorting on the basis of GFP signal at day 6, 15 and 21 post-injection. Our aims was to study the transcriptional impact of the beta-catenin during the early steps of liver tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
15 Samples

Download data: BW

Series

Accession:: GSE210482

ID:: 200210482

PubMed Similar studies

Select item 20020626211.

RNA and miRNA profiles in mouse hepatocytes ApcdeltaHep ROSA or DLK1DeltaWRE

(Submitter supplied) We analyzed the expression of RNAs and microRNAs in hepatocytes isolated from ApcDeltaHep livers, either ROSA26 or deleted for the b-catenin binding site upstream of the DLK1/DIO3 locus by Crispr/Cas9 (DLK1DeltaWRE). We thus explored if editing of this regulatory site impaired the expression of the entire locus and which signaling pathways were modulated.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19057
17 Samples

Download data: CSV, RESULTS, TSV, TXT

Series

Accession:: GSE206262

ID:: 200206262

PubMed Similar studies

Select item 20002009912.

microRNA/UCR expression profiling of human Barrett's carcinogenesis

(Submitter supplied) To test the hypothesis that there are specific miRNA/UCR expression signature which characterizes Barrett's esophagus development and progression, we performed miRNA/UCR microarray analysis comparing normal esophageal squamous epithelium with all the phenotypic lesions seen in the Barrett's carcinogenic process

Organism:: Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL8871
51 Samples

Download data: GPR

Series

Accession:: GSE20099

ID:: 200020099

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021351813.

A novel kinase inhibitor for b-catenin mutant hepatocellular carcinoma II

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21626 GPL24247
23 Samples

Download data: BW

Series

Accession:: GSE213518

ID:: 200213518

PubMed Full text in PMC Similar studies

Select item 20021351714.

A novel kinase inhibitor for b-catenin mutant hepatocellular carcinoma [RNA-seq]

(Submitter supplied) We screened HCC organoids to identify a CTNNB1-mutant HCC selective small molecule (WNTinib), with MOA depending on reactivation of cytoplasmic EZH2, leading to its nuclear translocation and selective transcriptional block of WNT targets We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 genetically different organoids at 3 time points.