Similar studies for GEO DataSets (Select 200079462) - GEO DataSets

Select item 2000794621.

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
36 Samples

Download data: CEL

Series

Accession:: GSE79462

ID:: 200079462

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000794612.

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [organoids]

(Submitter supplied) The aim of this study was to determine the effects of TGFβ at the premalignant stage of CRC development. Organoid cultures were isolated from normal colon and from tubular adenomas. One normal colon culture was genetically engineered using the CRISPR-Cas9 system to carry the BRAFV600E mutation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
20 Samples

Download data: CEL

Series

Accession:: GSE79461

ID:: 200079461

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000794603.

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas]

(Submitter supplied) Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to determine the activity of TGFβ signaling and the role of this cytokine in subtype affiliation. Adenoma samples were collected in the Academic Medical Center (AMC), Amsterdam, The Netherlands. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
16 Samples

Download data: CEL

Series

Accession:: GSE79460

ID:: 200079460

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002372494.

Consensus molecular subtype transition during progression of colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL33581 GPL33582
72 Samples

Download data: RCC

Series

Accession:: GSE237249

ID:: 200237249

Select item 2002372485.

Consensus molecular subtype transition during progression of colorectal cancer [Tumor Signaling 360™ Panel]

(Submitter supplied) The consensus molecular subtype (CMS) classification divides colorectal cancer (CRC) into four distinct subtypes based on RNA-expression profiles. The biological differences between CMSs are already present in CRC precursor lesions, but not all CMSs pose the same risk of malignant transformation. To fully understand the path to malignant transformation and to determine whether CMS is a fixed entity during progression, genomic and transcriptomic data from two regions of the same CRC lesion were compared: the precursor and carcinoma region. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL33582
24 Samples

Download data: RCC

Series

Accession:: GSE237248

ID:: 200237248

Select item 2002372476.

Consensus molecular subtype transition during progression of colorectal cancer [NanoClassifier Gene Set]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL33581
48 Samples

Download data: RCC

Series

Accession:: GSE237247

ID:: 200237247

Select item 2001612777.

Dissecting the Epithelial and Immune Evolution during Colorectal Carcinogenesis by Single-Cell RNA Sequencing

(Submitter supplied) Adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal carcinoma. However, cellular heterogeneity in aberrant epithelia and the complexity of tumor microenvironment limited the understanding of carcinogenesis. Here we performed a scRNA-seq survey from patient-matched samples, including blood, normal, para-cancer, polyp, and cancer tissues.