GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10558 GPL6885

87 Samples

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(Submitter supplied) The radiolabelled somatostatin analogue 177Lu-octreotate is a promising treatment option for malignant neuroendocrine tumors that overexpress somatostatin receptors. The human small intestine neuroendocrine tumor cell line GOT1 and Medullary thyroid carcinoma model GOT2 have shown promising treatment response to 177Lu-octreotate in xenografted mice. In clinical studies, however, only low cure rates have been achieved to date. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

73 Samples

Download data: TXT

(Submitter supplied) The radiolabelled somatostatin analogue 177Lu-octreotate is a promising treatment option for malignant neuroendocrine tumors that overexpress somatostatin receptors. The human small intestine neuroendocrine tumor cell line GOT1 and Medullary thyroid carcinoma model GOT2 have shown promising treatment response to 177Lu-octreotate in xenografted mice. In clinical studies, however, only low cure rates have been achieved to date. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

14 Samples

Download data: TXT

(Submitter supplied) This work aimed to examine the regulation of apoptosis-related genes in GOT1 tumors one and seven days after administration of 177Lu-octreotate with and without A1M and of A1M alone. At study start, 22 adult female Balb/c GOT1 tumor-bearing mice were divided into four groups of six animals that received 30 MBq 177Lu-octreotate or 5 mg/kg A1M, or co-treatment with both 177Lu-octreotate and A1M by i.v. more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL32151

22 Samples

Download data: TXT, XLSX

(Submitter supplied) The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues such as octreotide have been used in clinic to treat patients with neuroendocrine tumors (NETs). However, the molecular mechanism leading either to successful therapy or acquired resistance to the analogues is still to large extent unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4330

Platform:

GPL6244

8 Samples

Download data: CEL, CHP

Analysis of ileum neuroendocrine tumor (NET) cell line CNDT2.5 treated with octreotide for up to 16 months. Somatostain analog octreotide is used to treat NET patients. Results provided insight into molecular basis of successful octreotide therapy or the development of drug resistance in NETs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 5 cell line, 3 time sets

Platform:

GPL6244

Series:

GSE24358

8 Samples

Download data: CEL, CHP

(Submitter supplied) We sought to define the gene expression profiles of small intestine neuroendocrine tumors (SI-NETs) in order to identify clinically relevant subgroups of tumors, prognostic markers and novel targets for treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

43 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse tissue and blood following 177Lu irradiation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

108 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse kidney cortex and medulla following 177Lu irradiation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

72 Samples

Download data: TXT

(Submitter supplied) This study explores the hypothesis that stimulating the chemo-sensing olfactory receptor 51E1 (OR51E1) decreases SI-NET proliferation suggesting a mechanism that explains a difference in proliferative rate based on tumor location

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

2 Samples

Download data: XLSX

(Submitter supplied) RNA microarray analysis of low-dose and dose rate responses versus time after i.v. administration of 211At. Female BALB/c nude mice were intravenously injected with 1.7 kBq 211At and killed after 1 h, 6 h, or 7 d, or injected with 105 or 7.5 kBq and killed after 1 h and 6 h, respectively. Controls were mock-treated. Kidneys, liver, lungs, and spleen were excised, flash-frozen, and stored at -80°C. Total RNA was extracted and subjected to expression analysis using RNA microarray technology. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

80 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 211At irradiation Introduction The cellular response to stimuli can be studied on different molecular levels, including gene expression regulation. RNA microarray is a high-throughput technique that enables comparison of genome-wide transcriptional status between samples. 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

24 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 131At irradiation In the present investigation, microarray analysis was used to monitor transcriptional activity in thyroids in mice 24 h after 131I exposure. The aims of this study were to 1) assess the transcriptional patterns associated with 131I exposure in normal mouse thyroid tissue and 2) identify novel biomarkers for 131I exposure. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5803

Platform:

GPL6885

4 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profiling of normal mouse thyroid tissue following 211At irradiation Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer (LET) for creating DNA double strand breaks, and is thus proposed for radionuclide therapy when bound to tumor-seeking agents. Un-bound 211At accumulates in the thyroid gland. The concept of basal radiation-induced biological effects in thyroid tissue is to a high degree unknown and is most valuable. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT

Analysis of thyroid from normal BALB/c adults 24 hours after injection in the tail vein with 13, 130, or 260 kBq of radioactive iodine (131I). The absorbed doses to thyroid were 0.85, 8.5, or 17 Gy. Results provide insight into dose-specific molecular responses of thyroid after 131I administration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 dose sets

Platform:

GPL6885

Series:

GSE54594

4 Samples

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