GEO DataSets

(Submitter supplied) The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states is considered to be critical in metastatic processes, cancer progression, and treatment resistance. To investigate a transient epithelial-mesenchymal transition (EMT) in prostate adenocarcinoma, LNCaP cells with inducible and reversible expression of SNAI1 or SNAI2 were generated. Cells were treated with doxycycline to induce a SNAI1- or SNAI2-mediated EMT for 5 days and then subsequently removed for 3, 5, and 20 days to allow for MET. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16604

44 Samples

Download data: TXT

(Submitter supplied) TGF-beta is a known driver of epithelial-mesenchymal transition (EMT) which is associated with tumor aggressiveness and metastasis. However, EMT has not been fully explored in clinical specimens of castration-resistant prostate cancer (CRPC) metastases. To assess EMT in CRPC, gene expression analysis was performed on 149 visceral and bone metastases from 62 CRPC patients and immunohistochemical analysis was performed on 185 CRPC bone and visceral metastases from 42 CRPC patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15659

149 Samples

Download data: TXT

(Submitter supplied) Chronic activation of Notch1 synergizes with multiple oncogenic pathways altered in early prostate cancer to promote the development of prostate adenocarcinoma. Expression profiling revealed that these tumors display features of epithelial-to-mesenchymal transition, a cellular state associated with increased tumor aggressiveness.Tumors driven by Notch1 intracellular domain in combination with multiple pathways altered in prostate cancer are metastatic and resistant to androgen deprivation.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

8 Samples

Download data: TXT

(Submitter supplied) The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compared gene expression profiles of mouse prostate stem cells ( Lin-CD44+CD133+Sca-1+CD117+) and prostate non-stem cells (Lin-CD44-CD133-Sca-1-CD117-).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

9 Samples

Download data: TXT

(Submitter supplied) Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castration.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4120

Platform:

GPL570

10 Samples

Download data: CEL, TXT

NOD/SCID mice with established LuCaP35 xenografts were castrated, and tumors were isolated 4 weeks later. Androgen deprivation regresses androgen-dependent disease, but relapse often occurs in an androgen-independent manner. Results provide insight into the molecular basis of castration resistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE33316

10 Samples

Download data: CEL