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Links from GEO DataSets

Items: 13

1.

Effects of exendin-4 in Brunner's glands of male GLP-1R-/- and wild-type control mice

(Submitter supplied) To gain insight into the biological functions of the highly expressed GLP-1R in Brunner’s glands, transcriptome analyses were conducted in male GLP-1R-/- and wild-type control mice. Analyses were performed 6 hours after a single s.c. dose of exendin-4 (1.0mg/kg s.c.), following 18 hours of two doses of exendin-4 (1.0 mg/kg s.c., administered at 0 and 9 hours), and in untreated controls. Brunner’s glands were isolated by laser capture micro dissection and extracted total RNA was used for microarray profiling.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20766
18 Samples
Download data: CEL
Series
Accession:
GSE80119
ID:
200080119
2.

Gene expression data from lung 1 day after influenza infection with liraglutide

(Submitter supplied) We found liraglutide ameliorates influenza virus infection in mice.Using a microarray, we identified a group of up-regulated genes that could explain influenza improvement.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
6 Samples
Download data: TXT
Series
Accession:
GSE151886
ID:
200151886
3.

GLP-1 receptor signaling increases PCSK1 and beta-cell features in human alpha-cells

(Submitter supplied) Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under certain circumstances alpha-cells can express the prohormone convertase required for proglucagon processing to GLP-1, prohormone convertase 1/3 (PC1/3), and can produce GLP-1. However, the mechanisms through which this occurs are poorly defined. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
7 Samples
Download data: TXT
Series
Accession:
GSE163744
ID:
200163744
4.

Copper Metabolism Domain-Containing 1 Represses Genes That Promote Inflammation and Protects Mice From Colitis and Colitis-Associated Cancer

(Submitter supplied) Background & Aims Activation of the transcription factor nuclear factor-κB (NF-κB) has been associated with the development of inflammatory bowel disease (IBD). Copper metabolism MURR1 domain containing 1 (COMMD1), a regulator of various transport pathways, has been shown to limit NF-κB activation. We investigated the roles of COMMD1 in the pathogenesis of colitis in mice and IBD in human beings.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
12 Samples
Download data: TXT
Series
Accession:
GSE53368
ID:
200053368
5.

Genome-wide analysis of gene expression in mouse jejunum following exposure to the GLP-1R agonist exendin-4 or Fibroblast growth factor-7.

(Submitter supplied) To determine whether Ex-4 and Fgf7 acitvate a subset of overlapping gene expression profiles in mouse jejunum.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
30 Samples
Download data: TXT
Series
Accession:
GSE63841
ID:
200063841
6.

Transcriptome analysis of TNFR2-knockout mouse colon

(Submitter supplied) PURPOSE: The goal of this study was to determine the gene expression networks regulated by tumor necrosis factor receptor 2 (TNFR2, or Tnfrsf1b) and to evaluate their potential bearing on immune cell subsets and inflammatory bowel disease (IBD). METHODS: mRNA-seq was performed on isolated distal colons from TNFR2-knockout and wildtype mice. Differentially expressed transcripts were compared to human ulcerative colitis microarray datasets on Gene Expression Omnibus and to mouse immunological expression datasets at the Immunological Genome Project. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: CSV
Series
Accession:
GSE65408
ID:
200065408
7.

Gene expression study identifies important protective pathways utilized by appendicitis and appendectomy for ameliorating colitis

(Submitter supplied) BACKGROUND: Appendicitis followed by appendectomy (AA) at a young age protects against later inflammatory bowel disease (IBD). Using a novel murine appendicitis model we earlier demonstrated that AA proffered significant protection against subsequent experimental colitis. AIM: To delineate genes and biological pathways involved in the protective effect of AA against subsequent colitis using gene set enrichment analysis (GSEA) of DNA microarray data. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE23914
ID:
200023914
8.

Transcriptome study of colon epithelial cells in Reg3a-transgenic mice

(Submitter supplied) The human C-type lectin Reg3a (HIP/PAP) is an antimicrobial peptide that kills Gram-positive bacteria. Reg3a preserves gut microbiota homeostasis, reinforces intestinal barrier function and thereby helps to fight induced colitis in mice. Transcriptomic data revealed an upregulation of numerous genes involved in the robustness of the intestinal barrier, and the biosynthesis pathway of mucin core 1 and 3 O-glycans.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
35 Samples
Download data: CEL
Series
Accession:
GSE64932
ID:
200064932
9.

Effects of dietary curcumin and rutin on colonic inflammation and gene expression in mdr1a-/- mice, a model of IBD

(Submitter supplied) Damage of the intestinal epithelial barrier by xenobiotics or reactive oxygen species and a dysregulated immune response are both factors involved in the pathogenesis of inflammatory bowel diseases (IBD). Curcumin and rutin are polyphenolic compounds known to have anti-oxidant and anti-inflammatory activities, but their mechanism(s) of action are yet to be fully elucidated. Mdr1a-/- mice spontaneously develop intestinal inflammation, predominantly in the colon, with pathology similar to IBD, so this mouse model is relevant for studying diet-gene interactions and potential effects of foods on remission or development of IBD. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
8 Samples
Download data: GPR
Series
Accession:
GSE10684
ID:
200010684
10.

Changes in colon gene expression assoc. with increased colon inflam. in IL-10-/- mice inoculated with Enterococcus sp.

(Submitter supplied) Inappropriate response to normal intestinal bacteria is involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn’s Disease (CD), ulcerative colitis (UC)) and variations in the host genome may mediate this process. IL-10-/- mice develop CD-like colitis mainly in the colon, in part due to inappropriate responses to normal intestinal bacteria including Enterococcus strains. Comprehensive characterization of changes in gene expression associated with the observed inflammation in the IL-10-/- mouse model has yet to be reported. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
20 Samples
Download data: GPR, XLS
Series
Accession:
GSE12223
ID:
200012223
11.

Expression data from mouse colon tissue response to T cell transfer at week 0, 2, 4 and 6

(Submitter supplied) Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell dependent experimental colitis models have gained prominent favor as useful models to identify potential pathogenic mechanisms. The naïve CD4+CD45Rbhigh cell transfer model into recombinase activating gene-1 deficient (RAG-/-) mice induces both colitis and small bowel inflammation reflecting Crohn's disease with unclear pathogenic mechanisms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4363
Platform:
GPL1261
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE27302
ID:
200027302
12.
Full record GDS4363

CD4CD45Rbhi T-cell transfer colitis model: time course

Temporal analysis of colon tissue from RAG-1-/- C57BL/6 males injected with CD4+CD45RBhigh T cells from healthy wild type C57BL/6 males to induce colitis. T cells critically regulate clinical inflammatory bowel diseases (IBD). Results provide insight into the molecular basis of colitis development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 time sets
Platform:
GPL1261
Series:
GSE27302
16 Samples
Download data: CEL, CHP
13.

RNA-Seq analysis on the liver of mice treated with high-fat diet and liraglutide

(Submitter supplied) GLP-1 based diabetes drugs are effective to reduce hepatic lipid accumulation beyong glycemic control. As GLP-1 receptor (GLP-1R) is not expressed in hepatocytes, the mechanism behind the beneficial effects of GLP-1 based drugs on the liver remained elusive. Several studies have shown that the expression of hepatic fibroblast growth factor 21 (FGF21) can be stimulated by GLP-1-based drugs. Therefore, the present study aimed to assess such stimulation in mice and in mouse primary hepatocytes, determine whether hepatic FGF21 mediates functions of the GLP-1R agonist liraglutide, and to explore the potential mechanisms of liraglutide regulating the expression of FGF21. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: CSV
Series
Accession:
GSE168937
ID:
200168937
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