Similar studies for GEO DataSets (Select 200082323) - GEO DataSets

Select item 2000823231.

Distinct skeletal muscle gene regulation from active contraction, passive vibration, and whole body heat stress in humans

(Submitter supplied) We used a novel approach to study the acute effect of three physiologic stressors (active contractions, vibration, and systemic heat stress) in human skeletal muscle. Three hours after the completion of a dose of physiologic stress, we sampled the soleus (contraction and vibration) or vastus lateralis (heat) muscle and developed a unique gene expression signature for each stressor. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold change), PGC-1α (5.46 fold change), and ABRA (5.98 fold change); and repressed MSTN (0.56 fold change). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
34 Samples

Download data: CEL

Series

Accession:: GSE82323

ID:: 200082323

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Select item 2000634232.

Influence of muscle activity on paralyzed muscle

(Submitter supplied) We investigated the short and long term effects of electrically induced exercise on mRNA expression of human paralyzed muscle. We developed an exercise dose that activated the muscle for 0.6% of the day. The short term effects were assessed 3 hours after a single dose of exercise, while the long term effects were assessed after training 5 days per week for at least one year (adherence 81%). A single dose of electrical stimulation increased the mRNA expression of transcriptional, translational, and enzyme regulators of metabolism important to shift muscle toward an oxidative phenotype (PGC-1a, NR4A3, IFRD1, ABRA, PDK4). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
20 Samples

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Series

Accession:: GSE63423

ID:: 200063423

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Select item 2000646833.

Influence of low and high force muscle activity on paralyzed muscle gene expression

(Submitter supplied) We used a novel approach to study the acute effect of two frequencies of stimulation (20 Hz and 5 Hz; high and low force, respectively) on gene regulation in people with chronic paralysis. Three hours after the completion of the electrical stimulation protocol (5 Hz or 20 Hz), we sampled the vastus lateralis muscle and examined genes involved with metabolic transcription, glycolysis, oxidative phosphorylation, and mitochondria remodelling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
24 Samples

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Series

Accession:: GSE64683

ID:: 200064683

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Select item 2001424264.

Impact of short and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury

(Submitter supplied) Exercise attenuates the development of chronic non-communicable diseases (NCDs). Gene signaling pathway analysis offers an opportunity to discover if electrically induced muscle exercise regulates key pathways among people living with spinal cord injury (SCI). We examined short-term and long-term durations of electrically induced skeletal muscle exercise on complex gene signaling pathways, specific gene regulation, and epigenetic tagging of PGC1a, a major transcription factor in skeletal muscle of men with SCI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
30 Samples

Download data: CEL

Series

Accession:: GSE142426

ID:: 200142426

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Select item 2000735725.

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles

(Submitter supplied) Transcriptional microarray analysis was conducted on gastrocnemius muscle of control and PGC-1β(i)skm-/- mice one week after the last tamoxifen administration using the Affymetrix Mouse Gene 1.0 ST.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE73572

ID:: 200073572

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Select item 2000757856.

The microRNA expression profiles changes associated with constant heat stress in porcine skeletal muscle as measured by deep sequencing

(Submitter supplied) To characterize the changes of miRNAs in skeletal muscle responding to heat stress, the miRNA expression profiles of longissimus dorsi muscles of pigs raised under constant heat stress (30°C, n=8) or control temperature (22 C, n=8) for 21 days were analyzed by Illumina deep sequencing. 58 differentially expressed miRNAs were identified with 30 down-regulated and 28 up-regulated and 63 differentially expressed target genes were predicted by miRNA-mRNA joint analysis. more...

Organism:: Sus scrofa

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11429
2 Samples

Download data: XLS

Series

Accession:: GSE75785

ID:: 200075785

PubMed Similar studies SRA Run Selector

Select item 2000670497.

Microarray analysis of skeletal muscle in PGC1α transgenic mice

(Submitter supplied) Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC1α) is a coactivator of various nuclear receptors and other transcription factors that shows increased expression in skeletal muscle during exercise. In skeletal muscle, PGC1α is considered to be involved in contractile protein function, mitochondrial function, metabolic regulation, intracellular signaling, and transcriptional responses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

Download data: TXT

Series

Accession:: GSE67049

ID:: 200067049

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Select item 2001068658.

A longitudinal gene expression microarray analysis of skeletal muscle resistance training

(Submitter supplied) Skeletal muscle adapts to resistance exercise (RE) performance acutely and chronically. An important regulatory step of muscle adaptation to RE is gene expression. Microarray analysis can be used as an exploratory method to investigate how genes and gene clusters are modulated acutely and chronically by RE. The purpose of the present study was to investigate the effect of training status in the basal (rested) and pre- to 24h post-RE on the global transcriptome in vastus lateralis muscle biopsies of young men. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
40 Samples

Download data: IDAT, TXT

Series

Accession:: GSE106865

ID:: 200106865

Select item 2000877499.

An electrical pulse stimulation protocol to study acute epigenetic response to muscle cell contraction uncovers acute hydroxymethylation of the exercise-responsive gene Nr4a3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16417 GPL16791
56 Samples

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Series

Accession:: GSE87749

ID:: 200087749

PubMed Full text in PMC Similar studies

Select item 20008774810.

An electrical pulse stimulation protocol to study acute epigenetic response to muscle cell contraction uncovers acute hydroxymethylation of the exercise-responsive gene Nr4a3 [RNA-Seq]

(Submitter supplied) Physical exercise triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic factors like DNA methylation participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induces dynamic DNA demethylation at gene promoters, but the contribution of the demethylation precursor hydroxymethylcytosine is unknown. more...