Similar studies for GEO DataSets (Select 200083838) - GEO DataSets

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Items: 20

Select item 2000838381.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [rt-pcr]

(Submitter supplied) Thyroid transcription factor-1 (TTF-1), also known as NKX2-1, plays a role as a lineage-survival oncogene in lung adenocarcinoma with double-edged sword characteristics. Although previous studies steadily accumulated evidence for roles of TTF-1 in the transcriptional regulation of protein-coding genes, very little is known about its regulatory relationship with miRNAs. In this study, we have identified miR-532-5p as a novel transcriptional target of TTF-1 by an integrative approach, which was designed to extract maximal information from expression profiles of both patient tumors in vivo and TTF-1-inducible cell lines in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL11316
4 Samples

Download data: TXT

Series

Accession:: GSE83838

ID:: 200083838

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000838392.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by RT-PCR

Platforms:: GPL11316 GPL17077
99 Samples

Download data: TXT

Series

Accession:: GSE83839

ID:: 200083839

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000838373.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [cell line]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
20 Samples

Download data: TXT

Series

Accession:: GSE83837

ID:: 200083837

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000838364.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [pts]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
75 Samples

Download data: TXT

Series

Accession:: GSE83836

ID:: 200083836

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000405845.

Analysis of Nkx2-1-regulated gene expression in A549 lung carcinoma cells

(Submitter supplied) A transcription factor Nkx2-1 (also known as TTF-1) regulates the expression of different sets of genes. Gene expression analysis was performed using mRNAs from Nkx2-1-induced A549 cells compared to that from the control A549 cells. We used microarrays to detail the global program of gene expression controlled by Nkx2-1 and identified distinct classes of up-regulated and down-regulated genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE40584

ID:: 200040584

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000405086.

Expression data of mouse mucinous lung tumors

(Submitter supplied) Transgenic mice (Scgb1a1-rtTA/[tetO]-KRAS.G12D/Nkx2-1+/-) develop mucinous lung tumors. Gene expression analysis was performed using mRNAs from the whole lungs of the mice compared to that of the control mice. We used microarrays to detail the global program of gene expression underlying development of mucinous lung tumors and identified distinct classes of up-regulated genes during this process.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE40508

ID:: 200040508

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000336727.

Expression data of NCI-H441 cells stably expressing hsa-mir-365-2 vs empty vector

(Submitter supplied) Hsa-mir-365-2 is one of the two precursors that give rise to miR-365. We discovered that miR-365 directly regulates a lung cancer and developmental gene termed thyroid transcription factor 1 (TTF-1 or NKX2-1). Hsa-mir-365-2 was transfected into NCI-H441 cells via retrovirus-mediated gene transfer. Arrays hybridized: Affymetrix GeneChip Human Gene 1.0 ST Array.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5496
Platform:: GPL6244
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE33672

ID:: 200033672

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54968.

miR-365 expression effect on lung adenocarcinoma cell line

Analysis of NCI-H441 adenocarcinoma cells expressing hsa-miR-365-2, a precursor of miR-365. Results identify targets of miR-365 and the role of miR-365 in the pulmonary transcriptional program responsible for lung development and malignancy.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL6244
Series:: GSE33672
4 Samples

Download data: CEL

DataSet

Accession:: GDS5496

ID:: 5496

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001320119.

RNA-seq of DV90 cells with REG4 siRNA

(Submitter supplied) DV90 cells with REG4 siRNAs were subjected to RNA isolation and RNA-seq analyses were generated by deep sequencing using Illumina Hiseq.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
3 Samples

Download data: TXT

Series

Accession:: GSE132011

ID:: 200132011

Select item 20004325210.

Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

(Submitter supplied) Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of lung epithelial cells upon loss of their master cell fate regulator. Nkx2-1 deletion in normal and neoplastic lung causes not only loss of pulmonary identity but also gastric transdifferentiation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
31 Samples

Download data: BED, WIG

Series

Accession:: GSE43252

ID:: 200043252

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003647311.

Nkx2.1 represses a latent gastric differentiation program in lung adenocarcinoma

(Submitter supplied) During cancer evolution, cellular differentiation programs become dysregulated. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of lung epithelial cells upon loss of their master cell fate regulator. Nkx2-1 deletion in normal and neoplastic lung causes not only loss of pulmonary identity but also gastric transdifferentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
12 Samples

Download data: CEL, PGF, TXT

Series

Accession:: GSE36473

ID:: 200036473

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004705512.

The homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; synthetic construct

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL6246 GPL8786
12 Samples

Download data: CEL

Series

Accession:: GSE47055

ID:: 200047055

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004705413.

The homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (mRNA)

(Submitter supplied) Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expression. microRNAs are a class of small non-coding RNA that control one of the major mechanisms of gene repression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL

Series

Accession:: GSE47054

ID:: 200047054

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004705314.

The homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (microRNA)

Organism:: Mus musculus; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL8786
6 Samples

Download data: CEL

Series

Accession:: GSE47053

ID:: 200047053

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002687415.

Suppression of Lung Adenocarcinoma Progression by Nkx2-1

(Submitter supplied) Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-pathway2, using conditional alleles in mice3-5. Lentiviral-mediated somatic activation of oncogenic Kras and deletion of p53 in the lung epithelial cells of KrasLSL-G12D/+;p53flox/flox mice initiates lung adenocarcinoma development4. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
29 Samples

Download data: CEL, PGF, TXT

Series

Accession:: GSE26874

ID:: 200026874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007252616.

miRNAs classifiers are powerful diagnostic/prognostic tools in ALK, EGFR, KRAS driven lung cancer

(Submitter supplied) microRNA profiles of NSCLCs driven by ALK, EGFR or KRAS in order to find driver-specific diagnostic and prognostic microRNA signatures.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20275
85 Samples

Download data: TXT, XLS

Series

Accession:: GSE72526

ID:: 200072526

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004296217.

SABiosciences Human miRNA PCR array assay of normal respiratory epithelia and lung cancer cells with or without treatment of CSC

(Submitter supplied) MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in normal human respiratory epithelia and lung cancer cells cultured in the presence or absence of cigarette smoke condensate (CSC). more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16382
8 Samples

Download data: TXT

Series

Accession:: GSE42962

ID:: 200042962

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006000118.

MicroRNA profile of tumorigenic cells during formation of pulmonary adenocarcinoma

(Submitter supplied) Study designed to obtain microRNA profile of tumorigenic Sca-1+CD34+ cells during the formation of pulmonary adenocarcinoma. After intranasal infection with adenovirus CRE (Ad-Cre), lung adenocarcinoma was identified pathologically in Lox-stop-lox Kras (LSL-Kras) G12D mice. Sca-1+CD34+ cells were sorted by flow cytometry and tested for the tumor-initiating ability to undergo self-renewal and differentiation. more...

Organism:: Mus musculus; Murid betaherpesvirus 1; Murid gammaherpesvirus 4

Type:: Non-coding RNA profiling by array

Platform:: GPL19029
3 Samples

Download data: TXT

Series

Accession:: GSE60001

ID:: 200060001

Select item 20008363419.

Inhibition of NF-κB signaling by a novel siRNA sequence induces apoptosis and suppresses tumor growth in KRAS mutant colorectal cancer.

(Submitter supplied) KRAS mutation is one of the major genetic alterations in colorectal cancer (CRC). Treating patients with KRAS mutant CRC remains one of the biggest challenges in oncology. In this study, we aimed to discover an effective therapeutic microRNA (miRNA) that could target KRAS mutant CRC. For this purpose, we investigated the functional relevance of dysregulated miRNAs in KRAS mutant cancers. We transfected exogenous KRASG12V into human embryonic kidney 293 (HEK293) cells and human lung fibroblasts (MRC5) cells, and performed comprehensive microRNA expression profiling by microarray analysis. more...