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Dermal fibroblasts play a central role in skin model protection against C. albicans invasion

(Submitter supplied) This study shows that, in the presence of CD4+ T cells, dermal fibroblasts shift towards an antimicrobial phenotype leading to reduced dermal invasion by C. albicans. This is dependent on TLR2 activation and pro-IL-1β cleavage and results in expression of genes involved in defense against various classes of pathogens.
Organism:
Candida albicans SC5314; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL22432 GPL16791
18 Samples
Download data: TXT
Series
Accession:
GSE86926
ID:
200086926

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