GEO DataSets

(Submitter supplied) We aimed to investigate whether HRV infection induces a specific gene expression pattern in airway epithelial cells. The study suggests the underlying molecular regulatory networks genes which might be involved in pathogenicity of the HRV-B and potential targets for further validations and development of effective treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

24 Samples

Download data: CEL, CHP

(Submitter supplied) We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified sets of genes associated with asthma specific viral responses. These genes are related to inflammatory pathways, epithelial remodeling and cilium assembly and function, including those described previously (e.g. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

24 Samples

Download data: TXT

(Submitter supplied) This study was performed to test the hypothesis that cigarette smoke extract would alter the responses of primary cultures of human bronchial epithelial cells to infection with purified human rhinovirus 16. The data show marked alterations in rhinovirus-induced expression profiles of a number of genes in the presence of cigarette smoke extract (CSE).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4832

Platform:

GPL570

16 Samples

Download data: CEL, CHP

Analysis of cultured bronchial epithelial cells (BECs) after rhinovirus (RV) infection, cigarette smoke extract exposure, or both. The airway epithelial cell is the primary site of RV infection. Results provide insight into the impact of cigarette smoking on the response of BECs to RV infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 4 individual sets

Platform:

GPL570

Series:

GSE27973

16 Samples

Download data: CEL, CHP

(Submitter supplied) Primary human bronchial epithelial cells were transfected with siRNA to knockdown IRF7 gene expression, allowed to recover, and then infected with human rhinovirus. At 24 hrs post rhinovirus infection, gene expression patterns were profiled on microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20609

20 Samples

Download data: CEL

(Submitter supplied) Background: Rhinovirus (HRV) is associated with the large majority of virus-induced asthma exacerbations in children and young adults, but the mechanisms remain poorly defined. Methods: Asthmatics and non-asthmatic controls were inoculated with HRV-A16, and nasal epithelial samples were obtained 7 days before, 36 hours after, and 7 days after viral inoculation. RNA was extracted and subjected to RNA-seq analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15433

33 Samples

Download data: TXT

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) RATIONALE: Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases. OBJECTIVES: To define changes in gene expression profiles during in vivo rhinovirus infections. METHODS: Nasal epithelial scrapings were obtained before and during experimental rhinovirus infection, and gene expression was evaluated by microarray. Naturally acquired rhinovirus infections, cultured human epithelial cells, and short interfering RNA knockdown were used to further evaluate the role of viperin in rhinovirus infections. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

93 Samples

Download data: CEL, CHP

(Submitter supplied) The severity and outcome of respiratory viral infections is partially determined by the cellular response mounted by infected lung epithelial cells. Disease prevention and treatment is dependent on our understanding of the shared and unique responses elicited by diverse viruses. We used microarray analysis to compare changes in gene expression of murine lung epithelial cells infected by one of three respiratory viruses causing mild (rhinovirus, RV1B), moderate (coronavirus, MHV-1), and severe (influenza A virus, PR8) disease in mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL15887

21 Samples

Download data: XYS

(Submitter supplied) Analysis of human alveolar epithelial cell signatures at gene expression level. The aim of the study was to identify candidate genes that are induced in human alveolar epithelial type II cells on collagen-coated dishes. Results provide important information about changes hAT2 cells undergo in the transformation to AT1-like cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

24 Samples

Download data: TXT