Similar studies for GEO DataSets (Select 200094318) - GEO DataSets

Select item 2000943181.

Expression profiling by array in the splenic marginal zone lymphoma (SMZL)

(Submitter supplied) The transformation mechanism into a high-grade malignancy of SMZL has not been well studied. To define and compare the differentially expressed genes between primary SMZL cells at the different clinical periods, we analyzed the gene expression profiles using the CodeLink Human Whole Genome Bioarray.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL2895
2 Samples

Download data: TXT

Series

Accession:: GSE94318

ID:: 200094318

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000353832.

INTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by array; Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array

7 related Platforms
148 Samples

Download data: CEL, TXT

Series

Accession:: GSE35383

ID:: 200035383

Select item 2000353673.

INTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (CGH)

(Submitter supplied) Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas (p<10-6). The presence of unmutated IgVH genes, genomic complexity, 17p13-P53 deletion and 8q gain including MYC gene, but not 7q deletion, were correlated with shorter overall survival. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platforms:: GPL15168 GPL3869 GPL3868
76 Samples

Download data: TXT

Series

Accession:: GSE35367

ID:: 200035367

Select item 2000353294.

INTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (SNP data)

(Submitter supplied) Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas (p<10-6). The presence of unmutated IgVH genes, genomic complexity, 17p13-P53 deletion and 8q gain including MYC gene, but not 7q deletion, were correlated with shorter overall survival. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:: GPL3718 GPL3720 GPL2005
63 Samples

Download data: CEL

Series

Accession:: GSE35329

ID:: 200035329

PubMed Similar studies

Select item 2000350825.

INTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (expression)

(Submitter supplied) Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas (p<10-6). The presence of unmutated IgVH genes, genomic complexity, 17p13-P53 deletion and 8q gain including MYC gene, but not 7q deletion, were correlated with shorter overall survival. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE35082

ID:: 200035082

Select item 2000178956.

Somatic Mutation Screen of Clear Cell RCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9101
160 Samples

Download data: CEL, TXT

Series

Accession:: GSE17895

ID:: 200017895

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Select item 2000178187.

Somatic Mutation Screen of Clear Cell RCC II

(Submitter supplied) Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9101
115 Samples

Download data: CEL, TXT

Series

Accession:: GSE17818

ID:: 200017818

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Select item 2000178168.

Somatic Mutation Screen of Clear Cell RCC I

(Submitter supplied) Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/. These samples were run at a different facility than VARI - scmmlab.com

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9101
45 Samples

Download data: CEL, TXT

Series

Accession:: GSE17816

ID:: 200017816

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Select item 2000354269.

An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma (Affymetrix HG-U133plus2 gene expression microarray)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE35426

ID:: 200035426

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Select item 20003542510.

An integrated genomic and expression analysis of 7q deletion in SMZL (Oligo aCGH)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10383
21 Samples

Download data: TXT

Series

Accession:: GSE35425

ID:: 200035425

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Select item 20003542411.

An integrated genomic and expression analysis of 7q deletion in SMZL (Illumina Infinium Human Methylation 27 array)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
24 Samples

Download data: TXT

Series

Accession:: GSE35424

ID:: 200035424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003534812.

An Integrated genomic and expression analysis of 7q deletion in SMZL

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
27 Samples

Download data: CEL

Series

Accession:: GSE35348

ID:: 200035348

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003527813.

Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities

(Submitter supplied) Lymphoplasmacytic lymphomas and marginal zone lymphomas of nodal, extra-nodal and splenic types account for 10% of non-Hodgkin lymphomas. They are similar at the cell differentiation level, sometimes making difficult to distinguish them from other indolent non-Hodgkin lymphomas. To better characterize their genetic basis, we performed array-based comparative genomic hybridization in 101 marginal zone lymphomas (46 MALT, 35 splenic and 20 nodal marginal zone lymphomas) and 13 lymphoplasmacytic lymphomas. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL4091
114 Samples

Download data: TXT

Series

Accession:: GSE35278

ID:: 200035278

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Select item 20002155414.

An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma (Main Study)

(Submitter supplied) Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, transcriptomic and miRNomic data. High resolution array comparative genomic hybridization of 56 cases of SMZL delineated a minimally deleted region (2.8Mb) at 7q32, but showed no evidence of any cryptic homozygous deletion or recurrent breakpoint in this region. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array; Expression profiling by array; Methylation profiling by array

Platforms:: GPL10383 GPL570 GPL8490
69 Samples

Download data: CEL, TXT

Series

Accession:: GSE21554

ID:: 200021554

PubMed Full text in PMC Similar studies Analyze with GEO2R

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