Similar studies for GEO DataSets (Select 200095119) - GEO DataSets

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Items: 18

Select item 2000951191.

Gene expression profile of tumors developed in the spleen of p53-haploinsufficient mice

(Submitter supplied) We aimed to ivestigate the effects of LSD1 on the gene expression program of p53-haploinsufficient mice to understand the molecular mechanisms underlying the development of lymphoid malignancies.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
3 Samples

Download data: TXT

Series

Accession:: GSE95119

ID:: 200095119

Select item 2000719752.

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas

(Submitter supplied) We used gene transcript profiling to gain a deeper understanding of the role of FBXW7 in tumor development and to determine the influence of mTOR inhibition by rapamycin on tumor transcriptome and biological functions. In comparison to tumors from p53 single heterozygous (p53+/-) mice, we find that tumors from Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice show significant deregulation of cholesterol metabolic processes independent of rapamycin treatment, while cell cycle related genes were upregulated in tumors from placebo treated Fbxw7+/-p53+/- mice, but not in tumors from rapamycin treated Fbxw7+/-p53+/- mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
40 Samples

Download data: TXT

Series

Accession:: GSE71975

ID:: 200071975

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000267233.

aCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas

(Submitter supplied) Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood solid tumours and severe chromosomal instability. In contrast to BRCA1- or BRCA2-associated cancers, breast tumours in heterozygous PALB2 mutation carriers do not show loss of the wild type allele, suggesting PALB2 might be haploinsufficient for tumour suppression. more...

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platform:: GPL11620
26 Samples

Download data: PAIR, TXT

Series

Accession:: GSE26723

ID:: 200026723

Select item 2000632714.

A Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory

(Submitter supplied) LSD1n regulates transcriptional elongation by removing H4K20 methylation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
41 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE63271

ID:: 200063271

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000900245.

Transcriptome analysis to investigate the oncogenic TGF-β-Smad-Snail signaling pathway

(Submitter supplied) Our study shows that TGF-β signaling promotes tumorigenesis in the liver through upregulation of its target gene, Snail. We explored gene expression changes in tumors following TGF-β inhibition, and tumors ectopically expressing Snail with the TGF-β inhibition. RNA samples were harvested from tumors expressing Smad7 (S7HP tumors), firefly luciferase (LHP tumors), and Smad7 plus Snail (S7HP+Snail), respectively. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: TXT

Series

Accession:: GSE90024

ID:: 200090024

PubMed Similar studies SRA Run Selector

Select item 2001119506.

Effect of mutant TRP53 proteins on nutlin-3a treated mouse lymphoma cell lines (RNA-seq)

(Submitter supplied) Mutations in TRP53, prevalent in human cancers, reportedly drive tumorigenesis through dominant-negative-effects (DNE) over wt TRP53 and neomorphic gain-of-function (GOF) effects. We show that five TRP53 mutants do not accelerate lymphomagenesis on a TRP53-deficient background but strongly synergize with c-MYC over-expression. RNA-seq analysis revealed that mutant TRP53 does not globally repress wt TRP53 function but exerts a DNE with disproportionate impact on subsets of wt TRP53 target genes, particularly those involved in DNA repair, proliferation and metabolism. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
36 Samples

Download data: TXT

Series

Accession:: GSE111950

ID:: 200111950

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000758577.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [HA-H33-H31_ChIP]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: BED

Series

Accession:: GSE75857

ID:: 200075857

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000758568.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Cbx2_ChIP]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
3 Samples

Download data: TXT

Series

Accession:: GSE75856

ID:: 200075856

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000758559.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [H31_ChIP-Rx]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas

Organism:: Drosophila melanogaster; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21227
6 Samples

Download data: TXT

Series

Accession:: GSE75855

ID:: 200075855

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007585410.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1a-1b_RNASeq]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE75854

ID:: 200075854

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007585311.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_Chondroblastoma_H3K36M_H3WT]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TSV

Series

Accession:: GSE75853

ID:: 200075853

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20006929112.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus; Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL17021 GPL21227
69 Samples

Download data

Series

Accession:: GSE69291

ID:: 200069291

PubMed Full text in PMC Similar studies

Select item 20006928913.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [ChIP-Rx]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE69289

ID:: 200069289

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006928614.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1b_ChIP]

(Submitter supplied) The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE69286

ID:: 200069286

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006928515.

Histone H3K36M mutation impairs mesenchymal differentiation and drives sarcoma development [RNA_H33_K36M_HMT]

(Submitter supplied) The goal of this study is to understand the alterations in transcriptome induced by histone H3K36M mutations

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: TXT

Series

Accession:: GSE69285

ID:: 200069285

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006927816.

H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_H31K36M_H33LAIMR]

(Submitter supplied) The goal of this study is to understand the alterations in transcriptome induced by histone H3K36M mutations

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TSV

Series

Accession:: GSE69278

ID:: 200069278

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007429417.

Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet in P53 -/- mice

(Submitter supplied) Gene expression for genes differentially expressed between early vs. late tumor onset and high fat diet (HFD) vs. low fat diet (LFD) in P53 -/- mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
41 Samples

Download data: TXT

Series

Accession:: GSE74294

ID:: 200074294

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007437718.

Overexpression of PHF8 promotes an EMT-related gene signature in MCF10A cells

(Submitter supplied) PHF8 exerts distinct functions in different types of cancer. However, the mechanisms underlying its specific functions in each case remain obscure. To establish whether overexpression of PHF8 regulates the TGF-β induced the epithelial-mesenchymal transition (EMT), we treated MCF10A-Mock (control) and MCF10A-PHF8wt (overexpressing wild-type PHF8) cells with TGF-β1 for 0, 24, 48 and 72 hours and performed RNA-seq in biological duplicates. more...