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Links from GEO DataSets

Items: 17

1.

4 or 14-Day Food Restriction Study in Sprague Dawley Rats

(Submitter supplied) This study is designed to determine effects on parameters routinely measured in toxicology studies
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
49 Samples
Download data: CEL
Series
Accession:
GSE98621
ID:
200098621
2.

Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes

(Submitter supplied) Context-specific Genome-scale Metabolic Network Reconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predict biomarkers of liver toxicity using the Transcriptionally Inferred Metabolic Biomarker Response (TIMBR) algorithm. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
18 Samples
Download data: TSV
Series
Accession:
GSE129814
ID:
200129814
3.

Expression data of LoVo cells treated by 10mM metformin for eigher 8 or 24h

(Submitter supplied) Metformin is effective for prevention or treatment of various tumors. There are a lot of studies on the underlying mechanisms of metformin as respect to its anti-tumor action. We used microarrays to detail the global programme of gene expression underlying the anti-tumor effects of metformin on LoVo cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE67342
ID:
200067342
4.

Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
123 Samples
Download data: CEL
Series
Accession:
GSE25484
ID:
200025484
5.

Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig (HP data set)

(Submitter supplied) German landrace gilts were fed a high protein diet (HP, 30% CP) throughout their whole pregnancy. Subsequently hepatic transcriptome profiles of the offspring were analysed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn) Keywords: ANOVA
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
63 Samples
Download data: CEL
Series
Accession:
GSE25483
ID:
200025483
6.

Fetal programming of hepatic transcriptome in response to gestational dietary protein levels in the pig (AP data set)

(Submitter supplied) German landrace gilts were fed an adequate protein diet (AP, 12% CP) throughout their whole pregnancy. Subsequently hepatic transcriptome profiles of the offspring were analysed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn). Keywords: ANOVA
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
60 Samples
Download data: CEL
Series
Accession:
GSE25482
ID:
200025482
7.

Burn-CLP

(Submitter supplied) The experimental design included three biological replicates for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2235
Platform:
GPL341
9 Samples
Download data
Series
Accession:
GSE1781
ID:
200001781
8.
Full record GDS2235

Burn sepsis model: liver

Analysis of livers of animals subjected to moderate burn injury followed two days later by cecum ligation and puncture (CLP) to produce sepsis. The dual insult induces a systemic hypermetabolic state. Results provide insight into regulation of the hypermetabolic response in the liver.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL341
Series:
GSE1781
9 Samples
Download data
9.

Prepartum body condition score and plane of nutrition affect the hepatic transcriptome during the transition period in grazing dairy cows

(Submitter supplied) A transcriptomic approach was used to evaluate potential interactions between prepartum body condition score (BCS) and feeding management in the weeks before calving on hepatic metabolism during the transition period. Thirty-two mid-lactation grazing dairy cows of mixed age and breed were randomly allocated to one of four treatment groups in a 2 × 2 factorial arrangement: two prepartum BCS categories [4.0 (thin, BCS4) and 5.0 (optimal, BCS5); based on a 10-point scale], and two levels of energy intake during the 3 wk preceding calving (75 and 125% of estimated requirements). more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL11648
48 Samples
Download data: GPR, XLSX
Series
Accession:
GSE81958
ID:
200081958
10.

Transcriptomic profiling of five industrial wine yeast strains at three time points during allcoholic fermentation

(Submitter supplied) Our study involves a transcriptomic approach to the analysis of industrial yeast metabolism. Historically, among the hundreds of yeast species, Saccharomyces cerevisiae has played an important role in scientific investigations and industrial applications, and it is universally acknowledged as one of the model systems for eukaryotic organisms. Yeast is also an important component of the wine fermentation process and determines various attributes of the final product. more...
Organism:
Saccharomyces cerevisiae; Schizosaccharomyces pombe
Type:
Expression profiling by array
Dataset:
GDS3725
Platform:
GPL2529
43 Samples
Download data: CEL, CHP
Series
Accession:
GSE11651
ID:
200011651
11.
Full record GDS3725

Industrial wine yeast strains during fermentation: time course

Analysis of five industrial wine yeast strains during fermentation. Yeast is an important component of wine fermentation and determines various attributes of the final product. Results provide insight into the differences in wine yeast physiology and metabolism during fermentation.
Organism:
Schizosaccharomyces pombe; Saccharomyces cerevisiae
Type:
Expression profiling by array, count, 5 strain, 3 time sets
Platform:
GPL2529
Series:
GSE11651
43 Samples
Download data: CEL, CHP
12.

The effect of mequindox on gene expression in rat liver tissue

(Submitter supplied) Veterinary drug mequindox, 3-methyl-2-acethyl-quindoxaline-N-1,4-dioxide, belongs to a class of antibiotic and growth-prompting drug called quinoxalines that are often used in livestock and poultry industry. Previous researches focused on traditional toxicity. However, the effect of mequindox on endogenous metabolic profile remains unknown. We used microarrays to detail the global programme of gene expression underlying mequindox toxicity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
11 Samples
Download data: CEL
Series
Accession:
GSE30935
ID:
200030935
13.

Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat

(Submitter supplied) A high phosphorus (HP) diet causes disorders of renal function, bone metabolism, and vascular function. We previously demonstrated that DNA microarray analysis is an appropriate method to comprehensively evaluate the effects of a HP diet on kidney dysfunction such as calcification, fibrillization, and inflammation. We reported that type IIb sodium-dependent phosphate transporter is significantly up-regulated in this context. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE71201
ID:
200071201
14.

Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

(Submitter supplied) Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wildtype, PPARα-/-, CREB3L3-/- and combined PPARα/CREB3L3-/- mice were subjected to a 16-hour fast or 4 days of ketogenic diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
30 Samples
Download data: CEL
Series
Accession:
GSE121096
ID:
200121096
15.

Exposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines

(Submitter supplied) Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as well as exposures to military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS4953 GDS4954
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE51207
ID:
200051207
16.
Full record GDS4954

Cobalt effect on liver cell line MH1C1: dose response

Analysis of MH1C1 liver cells exposed to 160 or 310 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent, 3 dose sets
Platform:
GPL1355
Series:
GSE51207
12 Samples
Download data: CEL
17.
Full record GDS4953

Cobalt effect on liver cell line H4IIEC3: dose response

Analysis of H4IIEC3 liver cells exposed to 29 or 62 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent, 3 dose sets
Platform:
GPL1355
Series:
GSE51207
12 Samples
Download data: CEL
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