GEO DataSets

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of nine different naked mole-rat tissue from breeders and non-breeders.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

215 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Heterocephalus glaber; Cavia porcellus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21195 GPL22346

476 Samples

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(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from breeders and non-breeders.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

23 Samples

Download data: XLS

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of ten different guinea pig tissue from breeders and non-breeders.

Organism:

Cavia porcellus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22346

238 Samples

Download data: XLS

(Submitter supplied) Deep sequencing of mRNA from naked mole rat

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13793

13 Samples

Download data: BEDGRAPH

(Submitter supplied) The naked mole-rat (NMR) is an exceptionally long-lived rodent that does not show increased mortality with age, uniquely defining NMR as a demographically non-aging mammal. Here, we performed bisulfite sequencing on over one hundred NMR blood samples differing in age, assessing more than 3 million common CpG sites. We observed an information loss of the NMR methylome during aging suggesting that NMR ages. more...

Organism:

Heterocephalus glaber

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL21195

107 Samples

Download data: COV

(Submitter supplied) We compared RNA-seq expression patterns in liver, an organ with high oxidative metabolism and abundant spontaneous DNA damage, from humans, naked mole rats, and mice, differing in maximum lifespan over a range of ~100, 30, and 3 years, respectively, for 130 genes involved in DNA repair. The results show that the longer-lived species, human and naked mole rat, share higher expression of these DNA repair genes, including core genes in several DNA repair pathways. more...

Organism:

Heterocephalus glaber; Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL17021 GPL21195

9 Samples

Download data: CSV

(Submitter supplied) Deep sequencing of mRNA from Fukomys damarensis to uncover the reproduce regulation

Organism:

Fukomys damarensis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17710

16 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat1,2. To study whether the benefits of increased HMW-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHAS2). nmrHAS2 mice showed increase in hyaluronan levels in several tissues, and lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

144 Samples

Download data: TXT

(Submitter supplied) Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat1,2. To study whether the benefits of increased HMW-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHAS2). nmrHAS2 mice showed increase in hyaluronan levels in several tissues, and lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL16417

39 Samples

Download data: TXT

(Submitter supplied) Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat1,2. To study whether the benefits of increased HMW-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHAS2). nmrHAS2 mice showed increase in hyaluronan levels in several tissues, and lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan. more...

Organism:

Mus musculus; Homo sapiens; Rattus norvegicus

Type:

Expression profiling by array; Methylation profiling by array

Platform:

GPL28271

19 Samples

Download data: IDAT

(Submitter supplied) The naked mole rat (NMR; Heterocephalus glaber) exhibits cancer resistance and an exceptionally long lifespan of approximately 30 years. The longevity of the NMR is widely debated, as it poses challenges to theories associated with aging, cancer, and redox homeostasis. In the present study, we report unique mechanisms of cholesterol metabolism in NMR cells that could be responsible in part for their anti-senescent properties. more...

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

2 Samples

Download data: CSV

(Submitter supplied) The goal was to find genes which are differentially expressed between the naked mole-rat (Heterocephalus glaber) and the wild-type mice liver tissue. The genes which are most differentially expressed may provide a clue for the remarkable differences between naked mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments.

Organism:

Mus musculus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL9185 GPL13940

2 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18694 GPL21195

18 Samples

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(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from young and old animals. We identified differentially expressed genes and provide functional profiles, which give insights into the aging process of long-lived rodents.

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21195

9 Samples

Download data: XLS

(Submitter supplied) Heathly naked mole-rats kept under normal housing conditions harbor either a small or enlarged spleen. The aim of the study is to compare RNAseq of naked mole-rat (NM-R) small and enlarged spleens between them and to compare them with RNAseq of mouse spleen.

Organism:

Heterocephalus glaber; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21195 GPL17021

9 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca fascicularis; Mus musculus; Murina leucogaster; Peromyscus leucopus; Tamias sibiricus; Papio anubis; Ursus americanus; Petaurus breviceps; Castor canadensis

Type:

Expression profiling by high throughput sequencing

9 related Platforms

90 Samples

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(Submitter supplied) Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. more...

Organism:

Petaurus breviceps; Murina leucogaster; Papio anubis; Ursus americanus; Peromyscus leucopus; Tamias sibiricus; Macaca fascicularis; Castor canadensis

Type:

Expression profiling by high throughput sequencing

8 related Platforms

48 Samples

Download data: CSV

(Submitter supplied) This dataset consists of liver and kidney gene expression profiles of young UM-HET3 mice subjected to the following compounds for 1 month: AS-703026 (liver and kidney), enzastaurin (liver and kidney), GDC-0941 (liver and kidney), ascorbyl-palmitate (kidney), AZD8055 (kidney) and KU0063794 (kidney). Corresponding age-, sex- and strain-matched littermate controls for kidney are also presented. This dataset complements liver RNAseq profiles of control UM-HET3 mice and mice subjected to ascorbyl-palmitate, AZD8055 and KU0063794 (collected and sequenced at the same time) stored at GSE131868.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

42 Samples

Download data: CSV

(Submitter supplied) Cells were isolated from adult or fetal samples, using either A2B5 or CD140 as selection marker.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

8 Samples

Download data: CSV