Similar studies for GEO DataSets (Select 200100281) - GEO DataSets

Select item 2001002811.

COPD is accompanied by coordinated transcriptional perturbation in the quadriceps affecting the mitochondria and ECM

(Submitter supplied) In this experiment we catalogue transcriptional changes accompanying COPD in the quadriceps. We measure global gene transcription in the quadriceps using Affymetrix HuGene 1.1 ST arrays in an unselected cohort of 79 stable COPD patients in secondary care and 16 healthy age-and gender-matched controls. We identified 1,826 differentially expressed transcript clusters, comprising 6 modules of co-expressed genes, which differentially associate with clinical and immunological features of COPD.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
95 Samples

Download data: CEL

Series

Accession:: GSE100281

ID:: 200100281

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Select item 2000108282.

Vastus lateralis muscle of patients with an acute COPD exacerbation

(Submitter supplied) To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients. Keywords: cross-sectional patient study

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL2891
9 Samples

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Series

Accession:: GSE10828

ID:: 200010828

Select item 2001079713.

RNA sequencing of human bronchial epithelial cell transcriptomes after repopulation and differentiation on bronchial scaffolds from COPD patients and healthy donors

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is a serious global health problem characterized by chronic airway inflammation, progressive airflow limitation and destruction of lung parenchyma. Remodeling of the bronchial airways in COPD includes changes in both the bronchial epithelium and the subepithelial extracellular matrix (ECM). To explore the impact of an aberrant ECM on epithelial cell phenotype in COPD we developed a new ex vivo model, in which normal human bronchial epithelial (NHBE) cells repopulate and differentiate on decellularized human bronchial scaffolds derived from COPD patients and healthy individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
36 Samples

Download data: TXT

Series

Accession:: GSE107971

ID:: 200107971

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Select item 2000872924.

Transcriptomic analysis of lung tissue from cigarette smoke induced emphysema murine models and human COPD show shared and distinct pathways

(Submitter supplied) Although cigarette smoke (CS) is the primary risk factor for COPD, the underlying molecular mechanisms for the significant variability in developing COPD in response to CS are incompletely understood. We performed lung gene expression profiling of two different wild-type murine strains (C57BL/6J, NZW/LacJ) and two genetic models with mutations in COPD GWAS genes (HHIP, FAM13A) after 6 months of chronic CS exposure and compared the results to human COPD lung tissues. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
109 Samples

Download data: TXT

Series

Accession:: GSE87292

ID:: 200087292

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Select item 2000124725.

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) and squamous cell lung carcinoma (SCC) are both smoking-related diseases. Interestingly, COPD itself is a risk factor for SCC, and this is independent of smoking history. Inferring from this knowledge, it is plausible to assume that patients with COPD may have a different gene expression profile in normal bronchial epithelium and in SCC. To test this hypothesis, we compared gene expression profiles in bronchial epithelium and in SCC from patients with and without COPD. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
63 Samples

Download data: TXT

Series

Accession:: GSE12472

ID:: 200012472

Select item 2000122806.

Specific genomic aberrations in squamous cell lung carcinoma with lymph node or distant metastasis

(Submitter supplied) The majority of patients with squamous cell lung cancer (SCC) die because of metastatic disease. The genomic mechanisms underlying this metastatic behaviour are underexposed. We analyzed a cohort of patients with primary squamous cell carcinoma (SCC) using array-based comparative genomic hybridization (aCGH) to identify which genomic aberrations were related metastatic behaviour. The cohort consisted of 34 patients with a follow-up of at least 5 years, including 15 without any metastases, 8 with metastases in regional lymph nodes only, and 11 with metastases exclusively in distant organs within two years after surgery. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL7096
34 Samples

Download data: TXT

Series

Accession:: GSE12280

ID:: 200012280

Select item 2000235467.

Whole-genome gene expression profiles of non-tumorous human lung tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10379
1349 Samples

Download data: CEL

Series

Accession:: GSE23546

ID:: 200023546

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Select item 2000235458.

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).