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Links from GEO DataSets

Items: 13

1.

COPD is accompanied by coordinated transcriptional perturbation in the quadriceps affecting the mitochondria and ECM

(Submitter supplied) In this experiment we catalogue transcriptional changes accompanying COPD in the quadriceps. We measure global gene transcription in the quadriceps using Affymetrix HuGene 1.1 ST arrays in an unselected cohort of 79 stable COPD patients in secondary care and 16 healthy age-and gender-matched controls. We identified 1,826 differentially expressed transcript clusters, comprising 6 modules of co-expressed genes, which differentially associate with clinical and immunological features of COPD.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
95 Samples
Download data: CEL
Series
Accession:
GSE100281
ID:
200100281
2.

Vastus lateralis muscle of patients with an acute COPD exacerbation

(Submitter supplied) To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients. Keywords: cross-sectional patient study
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2891
9 Samples
Download data
Series
Accession:
GSE10828
ID:
200010828
3.

RNA sequencing of human bronchial epithelial cell transcriptomes after repopulation and differentiation on bronchial scaffolds from COPD patients and healthy donors

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is a serious global health problem characterized by chronic airway inflammation, progressive airflow limitation and destruction of lung parenchyma. Remodeling of the bronchial airways in COPD includes changes in both the bronchial epithelium and the subepithelial extracellular matrix (ECM). To explore the impact of an aberrant ECM on epithelial cell phenotype in COPD we developed a new ex vivo model, in which normal human bronchial epithelial (NHBE) cells repopulate and differentiate on decellularized human bronchial scaffolds derived from COPD patients and healthy individuals. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
36 Samples
Download data: TXT
Series
Accession:
GSE107971
ID:
200107971
4.

Transcriptomic analysis of lung tissue from cigarette smoke induced emphysema murine models and human COPD show shared and distinct pathways

(Submitter supplied) Although cigarette smoke (CS) is the primary risk factor for COPD, the underlying molecular mechanisms for the significant variability in developing COPD in response to CS are incompletely understood. We performed lung gene expression profiling of two different wild-type murine strains (C57BL/6J, NZW/LacJ) and two genetic models with mutations in COPD GWAS genes (HHIP, FAM13A) after 6 months of chronic CS exposure and compared the results to human COPD lung tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
109 Samples
Download data: TXT
Series
Accession:
GSE87292
ID:
200087292
5.

A COPD-related gene expression signature in squamous cell lung cancer

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) and squamous cell lung carcinoma (SCC) are both smoking-related diseases. Interestingly, COPD itself is a risk factor for SCC, and this is independent of smoking history. Inferring from this knowledge, it is plausible to assume that patients with COPD may have a different gene expression profile in normal bronchial epithelium and in SCC. To test this hypothesis, we compared gene expression profiles in bronchial epithelium and in SCC from patients with and without COPD. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1708
63 Samples
Download data: TXT
Series
Accession:
GSE12472
ID:
200012472
6.

Specific genomic aberrations in squamous cell lung carcinoma with lymph node or distant metastasis

(Submitter supplied) The majority of patients with squamous cell lung cancer (SCC) die because of metastatic disease. The genomic mechanisms underlying this metastatic behaviour are underexposed. We analyzed a cohort of patients with primary squamous cell carcinoma (SCC) using array-based comparative genomic hybridization (aCGH) to identify which genomic aberrations were related metastatic behaviour. The cohort consisted of 34 patients with a follow-up of at least 5 years, including 15 without any metastases, 8 with metastases in regional lymph nodes only, and 11 with metastases exclusively in distant organs within two years after surgery. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL7096
34 Samples
Download data: TXT
Series
Accession:
GSE12280
ID:
200012280
7.

Airway epithelial gene expression in asthma versus healthy controls

(Submitter supplied) Airway epithelial brushings were obtained for microarray analysis by research bronchoscopy in 62 subjects with mild-to-moderate asthma not on inhaled steroids and 43 healthy controls. Asthma subjects were stratified into 2 subgroups, Th2 high and Th2 low asthma, based on their expression of a three-gene signature of Type 2 inflammation: POSTN, SERPINB2, and CLCA1.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16311
105 Samples
Download data: CEL
Series
Accession:
GSE67472
ID:
200067472
8.

Whole-genome gene expression profiles of non-tumorous human lung tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
1349 Samples
Download data: CEL
Series
Accession:
GSE23546
ID:
200023546
9.

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
445 Samples
Download data: CEL
Series
Accession:
GSE23545
ID:
200023545
10.

Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
405 Samples
Download data: CEL
Series
Accession:
GSE23529
ID:
200023529
11.

Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
499 Samples
Download data: CEL
Series
Accession:
GSE23352
ID:
200023352
12.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic association studies, with IRP2 increased in the lungs of COPD patients. Here we demonstrate that mice deficient in IRP2 are protected from cigarette smoke (CS)-induced COPD. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE57073
ID:
200057073
13.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading.

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic association studies, with IRP2 increased in the lungs of COPD patients. Here we demonstrate that mice deficient in IRP2 are protected from cigarette smoke (CS)-induced COPD. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17777
11 Samples
Download data: CEL
Series
Accession:
GSE57048
ID:
200057048
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