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Links from GEO DataSets

Items: 10

1.

PGC-1a Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from ParvalbuminPositive Interneurons

(Submitter supplied) PGC-1a is a master regulator for cell mitochondrial and metabolism function. In this experiment neurons were infected with a PGC-1a/GFP adenovirus to examine what genes were upregulated by over expression. Known targets related to mitochondrial health were confirmed while new neuron specific targets were discovered.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE100341
ID:
200100341
2.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
3.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
4.

Analysis of PGC-1alpha overexpression effects on the whole transcriptome in cultured skeletal muscle cells

(Submitter supplied) The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a chief activator of the mitochondrial and metatolic program in skeletal muscle (skm) and prevents atrophy. Here we tested whether PGC-1α overexpression could restructure the transcriptome and metabolism of cultured human skeletal myotubes, which display an athropic phenotype. An oligonucleotide microarray analysis was used to reveal PGC-1α effects on the whole transcriptome, and the possible impact on fuel metabolism reprogramming was examined. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE28206
ID:
200028206
5.

Gene Expression Profiling of PGC-1a KO mouse striata

(Submitter supplied) Huntington’s Disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy metabolism have been implicated in HD pathogenesis. We report here that mutant huntingtin causes disruption of mitochondrial function by inhibiting expression of PGC-1a, a transcriptional coactivator that regulates several metabolic processes including mitochondrial biogenesis and respiration. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2391
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5786
ID:
200005786
6.
Full record GDS2391

PGC-1alpha transcriptional coactivator null mutation effect on the brain striatum

Analysis of brain striatum of PGC-1alpha transcriptional coactivator null mutants. PGC-1alpha regulates several metabolic processes. Altered energy metabolism is implicated in Huntington's disease (HD). Results provide insight into the role of PGC-1alpha in HD pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5786
6 Samples
Download data
DataSet
Accession:
GDS2391
ID:
2391
7.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE34773
ID:
200034773
8.

Regulation of HSF1-mediated transcriptional programs by PGC-1alpha

(Submitter supplied) We examined global gene expression patterns in response to PGC-1 expression in cells derived from liver or muscle. As our study revealed regulation of HSF1 by PGC-1alpha, in some experiments we knocked-down HSF1 using siRNAs in addition to inducing PGC-1alpha expression.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6246 GPL6244
19 Samples
Download data: CEL
Series
Accession:
GSE51498
ID:
200051498
9.

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression

(Submitter supplied) This RNA-seq dataset was generated to identify genes whose transcription relies on the CBP80-binding motif (CBM) of PGC-1α in C2C12 mouse myoblasts.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE103566
ID:
200103566
10.

Expression data form P90 mouse hippocampus - various mutant condition

(Submitter supplied) The level of Synaptotagmin-2 (Syt2) was altered by deletion of IPMK protein in the male mouse brain. We investigated gene expression changes in the hippocampal region of IPMK conditional knockout (cKO) mice by performing genome-wide transcriptome analyses. In this dataset, we include the expression data obtained from dissected mouse hippocampus using loss-of-function IPMK mutants. These data are used to obtain 5 genes that are differentially expressed in response to IPMK signaling
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
4 Samples
Download data: CEL, XLSX
Series
Accession:
GSE131748
ID:
200131748
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