Similar studies for GEO DataSets (Select 200101392) - GEO DataSets

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Items: 2

Select item 2001013921.

Toll-like receptors 2 and 4 control adaptive β-cell expansion in diet-induced obesity

(Submitter supplied) Adult pancreatic β cells are refractory to proliferation, a roadblock for the treatment of insulin-deficient diabetes. Consumption of energy-dense Western or high-fat diet (HFD) triggers mild adaptive β cell mass expansion to compensate for peripheral insulin resistance; however, the underlying molecular mechanism remains unclear. Here we show that Toll-like receptors (TLR) 2/TLR4 act as molecular “brakes” for diet-induced β cell replication in both mice and humans. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
14 Samples

Download data: CEL

Series

Accession:: GSE101392

ID:: 200101392

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001020272.

Gene expression profiles from islets of a β-cell-specific CB1-knockout mice

(Submitter supplied) The cannabinoid 1 receptor (CB1) regulates insulin sensitivity and glucose metabolism in peripheral tissues. CB1 is expressed on pancreatic beta (β)-cells where its functions have not been fully described. We generated a β-cell-specific CB1-knockout (β-CB1-/-) mouse to study the long-term consequences of CB1 ablation on β-cell function in adult mice. β-CB1-/- mice had increased basal- and stimulated-insulin secretion and intra-islet cAMP levels, resulting in primary hyperinsulinemia, as well as increased β-cell viability, proliferation, and islet area. more...