GEO DataSets

(Submitter supplied) Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca2+ release, reverses aging-induced memory impairment and neuronal Ca2+ dysregulation. Here, we test the hypothesis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulation. We gave hippocampal microinjections of FKBP1b-expressing viral vector to male rats at either 13-months-of-age (long-term) or 19-months-of-age (short-term) and tested memory performance in the Morris water maze at 21-months-of-age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

23 Samples

Download data: CEL

(Submitter supplied) Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways associated with aging-related cognitive impairment. Aged rats were separated into cognitively unimpaired (AU) or impaired (AI) groups, based on their Morris water maze performance relative to young-adult (Y) animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2639

Platform:

GPL341

78 Samples

Download data: CEL, EXP, XLS

Analysis of hippocampi from aged learning-impaired animals on the last day of training in the Morris water maze (MWZ) or 21 days post-training. The MWZ task is a dorsal hippocampal-dependent task. Results provide insight into the molecular basis of aging-related cognitive impairment.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 3 disease state, 3 protocol sets

Platform:

GPL341

Series:

GSE5666

78 Samples

Download data: CEL, EXP

(Submitter supplied) Male Fischer 344 rats aged 4 months (young, n=10), 14 months (mid-aged, n=10), and 24 months (aged, n=10) were trained sequentially on two tasks: Morris Spatial Water Maze (SWM) and Object Memory Task (OMT). The training/testing sequence lasted 7 d, and hippocampal tissue was collected 24 hr later. Training and testing occured on each day except for days 2 and 3 of the 7 d sequence. (01/10/05: Series was updated to correct mislabeling of all sample signal values within the Young Treatment Group) Keywords = bioinformatics Keywords = gene expression Keywords = memory Keywords = synaptic plasticity Keywords = myelin Keywords = inflamation Keywords = aging Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS520

Platform:

GPL85

29 Samples

Download data: CEL, TXT

Identification of aging-dependent cognitive decline gene expression. Hippocampal CA1 tissue collected from 4, 14, and 24 month old male Fischer 344 rats after 7 days training on water maze and object memory task.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL85

Series:

GSE854

29 Samples

Download data: CEL, TXT

(Submitter supplied) The therapeutic potential of histone deacetylase inhibitor (HDACi) treatment has attracted considerable attention in the emerging area of cognitive neuroepigenetics. The possibility that ongoing cognitive experience importantly regulates the cell biological effects of HDACi administration, however, has not been systematically examined. In an initial experiment addressing this issue, we tested whether water maze training influences the gene expression response to acute systemic HDACi administration in the young adult rat hippocampus. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

84 Samples

Download data: TXT

(Submitter supplied) Intranasal insulin is a safe and effective method for ameliorating memory deficits associated with pathological brain aging. However, the impact of different formulations and the duration of treatment on insulin’s efficacy and the cellular processes targeted by the treatment remain unclear. Here, we tested whether intranasal insulin aspart, a short-acting insulin formulation, could alleviate memory decline associated with aging and whether long-term treatment affected regulation of insulin receptors and other potential targets. more...

Organism:

Rattus; Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL23040

26 Samples

Download data: CEL

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3915

Platform:

GPL341

49 Samples

Download data: CEL

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age sets

Platform:

GPL341

Series:

GSE9990

49 Samples

Download data: CEL

(Submitter supplied) RNA samples were prepared from ipsilateral rat hippocampi 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls. For details please see Matzilevich et al., J Neurosci Res 2002 Mar 1;67(5):646-63. Keywords = Brain injury Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

3 Samples

Download data

(Submitter supplied) Vitamin D is an important calcium-regulating hormone with diverse functions in numerous tissues including the brain. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Using aging rodents, we attempted to model the range of human serum vitamin D levels, from deficient to sufficient, to test whether vitamin D could preserve or improve cognitive function with aging. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5345

Platform:

GPL6247

26 Samples

Download data: CEL

Analysis of hippocampus from F344 rats fed dietary supplement of cholecalciferol (vitamin D3) at doses of 10,000, 1000 and 100 IU/kg diet for 18 weeks. Results provide insight into molecular mechanisms underlying vitamin D-mediated synaptic function enhancement.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 dose sets

Platform:

GPL6247

Series:

GSE61326

26 Samples

Download data: CEL

(Submitter supplied) The goals of this study include examining long-lasting changes in hippocampal gene expression in males and in females after a systemic, subchronic immune challenge and transcriptional response to a subsequent, acute immune insult

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

24 Samples

Download data: TXT

(Submitter supplied) Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cognitive aging. Methodology: We measured sleep stages in young adult and aged F344 rats during inactive (enhanced sleep) and active (enhanced wake) periods. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3939

Platform:

GPL1355

12 Samples

Download data: CEL

Analysis of parietal cortices of young and aged F344 males implanted with telemetry devices to measure sleep architecture. Animals were trained in the Morris water maze to assess cognitive function. Results provide insight into possible mechanistic links between sleep changes and cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 6 specimen sets

Platform:

GPL1355

Series:

GSE24515

12 Samples

Download data: CEL

(Submitter supplied) Short-term folate deficiency has been linked to cognitive defects. Given folate’s role in regulating nucleotide synthesis and DNA and histone methylation, these changes are often linked to altered gene expression. We hypothesize that chronic folate deficiency will induce memory deficits that can be linked to tissue-specific changes in gene expression. This study placed mice on folic acid deficient or replete diets, containing either no source of folate or AIN-93G normal folic acid intake, beginning post-weaning and persisting through the end of adult life at 18 months. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL25015

12 Samples

Download data: TXT

(Submitter supplied) To evaluate differentially expressed genes and pathways in hippocampus between young (3-month-old, 3M) and aging (22-month-old, 22M) group. We then performed gene expression profiling analysis using data obtained from mRNA-seq in hippocampus of 3M and 22M group.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

6 Samples

Download data: XLSX

(Submitter supplied) Multiple mechanisms and pathophysiological changes after anesthesia, such as brain aging and neurodegenerative diseases. And the gene transcription patterns and modulation networks after general anesthesia remains to be elucidated. We used microarrays to detail the global programme of gene expression in rats after sevoflurane anesthesia and identified distinct classes of changed.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22388

6 Samples

Download data: CEL