GEO DataSets

(Submitter supplied) Since follicular lymphoma (FL) grade 3A often coexist with a FL1/2 component a linear progression model of FL1, FL2 and FL3A has been developed. FL3B, on the other hand, is supposed to be more closely related to diffuse large B-cell lymphoma (DLBCL) and both FL3B and DLBCL are often simultaneously present in one tumor (DLBCL/FL3B). To obtain more detailed insight into FL progression, comprehensive analysis of a well-defined set of FL1/2 (n=22), FL3A (n=16), FL3B (n=6), DLBCL/FL3B (n=9) and DLBCL (n=45) was performed using gene expression profiling, immunohistochemical staining and genetic analysis by fluorescence in situ hybridization (FISH).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

84 Samples

Download data: CEL

(Submitter supplied) MYC translocations are the biologic hallmark of Burkitt lymphomas but also occur in other mature B-cell lymphomas. If accompanied by chromosomal breaks targeting the BCL2 and/or BCL6 oncogenes, these MYC translocation-positive (MYC+) lymphomas are called double-hit lymphomas (DHLs); otherwise, the term single-hit lymphoma (SHL) is applied. In order to characterize the biologic features of these MYC+ lymphomas other than Burkitt lymphomas, we explored, after exclusion of molecular Burkitt lymphoma (mBL) as defined by gene expression profiling (GEP), the molecular, pathological and clinical aspects of 80 MYC translocation (MYC+) lymphomas (31 SHL, 26 BCL2+/MYC+, 14 BCL6+/MYC+, 6 BCL2+/BCL6+/MYC+ and 3 MYC+ lymphomas with unknown BCL6 status). more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL96

32 Samples

Download data: CEL, TXT

(Submitter supplied) Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been found in a significant number of patients with FL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

69 Samples

Download data: CEL

(Submitter supplied) Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene expression profiles between transformed DLBCL and their antecedent FL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2979

54 Samples

Download data

(Submitter supplied) The distinction between the Burkitt lymphoma and diffuse large B-cell lymphoma is imprecise using current diagnostic criteria. We applied transcriptional and genomic profiling to molecularly define Burkitt lymphoma. Gene expression profiling employing Affymetrix GeneChips (U133A) was performed in 220 mature aggressive B-cell lymphomas, including a core group of eight Burkitt lymphomas, which fulfilled all diagnostic criteria of the WHO classification. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

221 Samples

Download data: CEL, CSV

(Submitter supplied) Recently, a subset of MYC-translocation negative aggressive B-cell lymphomas resembling Burkitt lymphoma (BL) characterized by proximal gains and distal losses in the long arm of chromosome 11 has been described. In the 2016 revision of the WHO classification these MYC-translocation negative lymphomas have been introduced as new provisional entity designated “Burkitt-like lymphoma with 11q aberration” (MNBLL 11q). more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL22855

11 Samples

Download data: TXT

(Submitter supplied) Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation partners were cloned within the network “Molecular Mechanisms in Malignant Lymphomas” (MMML) by long-distance inverse polymerase chain reaction. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

271 Samples

Download data: CEL, TXT

(Submitter supplied) Individualized diagnosis prediction classifiers were successfully constructed through expression profiling of a total of 8,644 genes in 49 patients with relapse/refractory diffuse large B cell lymphoma, prospectively treated in a randomized trial. keyword(s): Diagnosis prediction

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

82 Samples

Download data: TXT

(Submitter supplied) To identify c-myc target genes by siRNA transfection in a lymphoma cell line. Keywords: time series design

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3278

4 Samples

Download data: GPR

(Submitter supplied) Burkitt Lymphoma patient samples using gene expression to create a molecular definition of the disease. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Keywords: clinical history design

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3706

303 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL27429 GPL570

448 Samples

Download data: CEL, TXT

(Submitter supplied) Copy Number Variations (CNVs) were identified performing Comparative Genomic Hybridization (CGH) on 225 patients after whole-genome amplification, using Agilent SurePrint G3 4x180K microarrays. CNVs were further integrated with gene expression (Affymetrix U133+2 arrays) and mutations (targeted DNA resequencing). Complete description of the methods, array quality checks and called segments are available as supplemental material in the corresponding publication.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL27429

225 Samples

Download data: TXT

(Submitter supplied) Diffuse large B-cell lymphoma (DLBCL) is currently divided into three main molecular subtypes, defined by gene expression profiling (GEP): Germinal Center B-cell like (GCB), Activated B-Cell like (ABC), and Primary Mediastinal B-cell Lymphoma (PMBL). DLBCL subtypes were determined according to patients' gene expression profiles.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

223 Samples

Download data: CEL

(Submitter supplied) Pet dogs may provide a useful large-animal model of spontaneously occuring non-Hodgkin lymphoma, but complete molecular characterization is lacking. We used gene expression microarrays to molecularly characterize canine lymphoma, and found similarities between canine B-cell lymphoma and human diffuse large B-cell lymphoma.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

58 Samples

Download data: CEL

(Submitter supplied) GEP on Affymetrix U133+2.0 microarrays was performed on 6 centroblasts and 6 paired centrocytes from human tonsils in order to explore CB/CC transition and GC-B cell specific signatures

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) CD40L and IL-21 are major contributors to the transcriptional emergency of PC identify genes in committed B cells. In order to decipher specific CD40L- and IL21-targeted genes, fresly purified human tonsil centroblasts (n=6) were cultured for 3 hours in presence or not of CD40L and IL-21 before transciptome analysis were performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) GEP on Affymetrix U133+2.0 microarrays was performed on ex vivo cell-sorted B lymphocytes from FL patients, according to the CD20hiCD44loCD38posIgDnegCD138neg phenotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

10 Samples

Download data: CEL

(Submitter supplied) Determination of the ion channel and transporters gene expression profile of Follicular Lymphoma (FL). We have compared it with that of the relapsed follicular pymphomas and with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

14 Samples

Download data: TXT

(Submitter supplied) The aim of this work was to identify the copy number aberrations (CNAs) by high-resolution array comparative genomic hybridization (aCGH) on 7 dogs with newly diagnosed FL and 5 dogs with newly diagnosed MZL.

Organism:

Canis lupus familiaris

Type:

Genome variation profiling by array

Platform:

GPL24897

12 Samples

Download data: TXT

(Submitter supplied) Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tissue-specific mesenchymal cells impact on the diversification of aggressive lymphoma clones is still unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

30 Samples

Download data: TXT