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Links from GEO DataSets

Items: 20

1.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18802
16 Samples
Download data: CEL
Series
Accession:
GSE107374
ID:
200107374
2.

Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/β-catenin Signaling

(Submitter supplied) Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/β-catenin signaling is likely to be a major effector of its tumor-promoting role.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: XLSX
Series
Accession:
GSE101061
ID:
200101061
3.

microRNAs in Wnt/b-catenin dependent murine HCC

(Submitter supplied) Wnt/b-catening dependent HCC mouse models was used to assess microRNA profiles downstream of Wnt/b-catening pathway in mice HCC
Organism:
Mus musculus
Type:
Other
Platform:
GPL17873
6 Samples
Download data: TXT
Series
Accession:
GSE78912
ID:
200078912
4.

Long non-coding RNA in liver of HCC mouse model

(Submitter supplied) Wnt/b-catening dependent HCC mouse models was used to assess T-UCR profiles in mice HCC downstream of Wnt/b-catening pathway.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL15691
6 Samples
Download data: TXT
Series
Accession:
GSE78911
ID:
200078911
5.

Long ncRNA in HCC cells

(Submitter supplied) Normal human hepatocytes and 3 different HCC cell lines have been analyzed for the global expression of long non coding RNA (lncRNA). Total RNA was extracted from each sample using RNeasy Kit (Qiagen) according to the manufacturer’s instructions. RNA quality was assessed by Nanodrop ND-1000 and Bioanalyser2100. DNA microarray The Human Long Non-coding RNA Array was manufactured by Roche NimbleGen. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL11269
4 Samples
Download data: PAIR
Series
Accession:
GSE25859
ID:
200025859
6.

Differential gene expression pattern of mouse livers transfected with dual oncogenes (day-7 post-injection data set)

(Submitter supplied) To understand global gene expression patterns of mouse livers upon dual-oncogene transfection, RNA sequencing and analysis were conducted on liver samples from Shp2F/F or Shp2∆H (Shp2F/F:Alb-cre) mice hydrodynamically injected with the combination of Met/β-Catenin or Met/PIK3CA .
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
18 Samples
Download data: DIFF
Series
Accession:
GSE109544
ID:
200109544
7.

Transcriptomic characterization of Hepatocellular Carcinoma with CTNNB1 mutation

(Submitter supplied) we report transcritomic characterization of changes in CTNNB1 mutation positive HCCs in comparison to paratumoral tissues
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9115
8 Samples
Download data: TXT
Series
Accession:
GSE55048
ID:
200055048
8.

Cooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz

(Submitter supplied) One of the transcriptional targets of b-catenin/TCF and a key downstream effector of the WNT/b-catenin pathway in several tissues is the MYC proto-oncogene, which encodes for a transcription factor that is a master regulator of proliferation- and growth-related genes. However, several evidences indicate that this epistatic relationship does not seem to occur in liver: indeed Myc was not induced upon b-catenin activation driven by APC loss, and Myc deletion in hepatocytes does not suppress the effects of APC loss on cell proliferation and liver zonation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL24247
33 Samples
Download data: TXT
Series
Accession:
GSE138296
ID:
200138296
9.

Global analysis of genes regulated by canonical Wnt pathway

(Submitter supplied) Up-regulation of canonical Wnt signaling has been implicated in liver fibrosis and cancer. To determine canonical Wnt target genes potentially implicated in these diseases, we performed microarray analysis of culture-activated rat hepatic stellate cells (HSCs) treated with canonical Wnt inhibitors, DKK-1, ICG-001, or FJ9.
Organism:
Rattus norvegicus albus; Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE76330
ID:
200076330
10.

YAP Inhibition in HCC cells (Hep3B)

(Submitter supplied) siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA. Loss of contact inhibition and anchorage-independent growth are hallmarks of cancer cells. In this context, frequent inactivation of the Hippo pathway and subsequent nuclear enrichment of the transcriptional coactivator yes-associated protein (YAP) uncouple cell proliferation and anti-apoptosis from contact inhibition, associated with uncontrolled tumor growth and tumor cell dissemination. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE35004
ID:
200035004
11.

Niclosamide ethanolamine reverses gene expression and inhibits growth of hepatocellular carcinoma in vitro and in vivo

(Submitter supplied) Hepatocellular carcinoma (HCC) is a fatal malignancy with a dismal prognosis. The recent advances in genomics and transcriptomics have led to large volumes of molecular data for HCC, providing an unprecedented opportunity to translate these data into more effective therapeutics. By creating HCC gene expression signatures and comparing with drug response signatures from multiple datasets, we identified four antihelminthics (from over 1000 FDA-approved drugs) that can reverse the HCC disease gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data: TXT
Series
Accession:
GSE77322
ID:
200077322
12.

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma

(Submitter supplied) Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal liver development. We found a major shift in expression of Wnt and RXR-α pathway genes (up and down, respectively) coincident with the transition from hepatoblasts to hepatocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5818
Platform:
GPL7202
11 Samples
Download data: TXT
Series
Accession:
GSE65063
ID:
200065063
13.
Full record GDS5818

Normal liver developmental stages: embryonic and postnatal

Analysis of hepatoblasts, immature hepatocytes and hepatocytes from livers at different developmental timepoints (embryonic day 14, embryonic day 18, post-natal day 5, post-natal day 56). Results provide insight into molecular mechanisms underlying normal liver development.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 age, 3 cell type, 2 development stage sets
Platform:
GPL7202
Series:
GSE65063
11 Samples
Download data: TXT
14.

ADAMTSL2, a missing link in Wnt/ß-catenin regulated CNS vascular development

(Submitter supplied) Context dependent molecular cues shape the formation of the cerebral vascular network and the function of the blood-brain barrier (BBB). The Wnt/ß-catenin pathway is orchestrating CNS vascular development, but downstream mediators have not been characterized. Here we generated an endothelial cell-specific R26-Axin1 overexpression (AOE) mouse model to inhibit Wnt/ß-catenin signaling. In AOE mice we discovered that blockade of Wnt/ß-catenin pathway leads to premature regression and remodeling without compromising BBB integrity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE66848
ID:
200066848
15.

β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma

(Submitter supplied) We study the role of CTNNB1 in immune escape in HCC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
22 Samples
Download data: TXT
Series
Accession:
GSE125336
ID:
200125336
16.

RNA Helicase DDX5, a Negative Regulator of Wnt Activation and Hepatocyte Reprogramming in Hepatitis B Virus-associated Hepatocellular Carcinoma

(Submitter supplied) We demonstrate that HBV infection induces expression of the proto-oncogenic miR17~92 and miR106b~25 clusters which target the downregulation of DDX5. Increased expression of these miRNAs is also detected in HBV-driven HCCs exhibiting reduced DDX5 mRNA. Stable DDX5 knockdown (DDX5KD) in HBV replicating hepatocytes increased viral replication, and resulted in hepatosphere formation, drug resistance, Wnt activation, and pluripotency gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
19 Samples
Download data: BED, BW, TXT
Series
Accession:
GSE131257
ID:
200131257
17.

Concomitant Nrf2 and beta-catenin activation in hepatocellular cancer subset

(Submitter supplied) In the current study, we want to explore the crosstalk between NFE2L2 and beta-catenin.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
9 Samples
Download data: CSV, WIG
Series
Accession:
GSE156386
ID:
200156386
18.

Transcriptomic analysis of two models of zebrafish beta-catenin-driven HCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18413 GPL24995
23 Samples
Download data: MTX, TSV
Series
Accession:
GSE137788
ID:
200137788
19.

Bulk transcriptomic analysis of two models of zebrafish beta-catenin-driven HCC

(Submitter supplied) Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. β-catenin has dual cellular functions as a component of the Wnt signaling pathway and adherens junctions. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and downstream activation of Wnt target genes. In patient HCC samples, β-catenin nuclear and cytoplasmic localization are typically patchy, even among HCC with highly active CTNNB1 mutations. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24995
20 Samples
Download data: TXT
Series
Accession:
GSE137787
ID:
200137787
20.

Single-cell transcriptomic analysis of two models of zebrafish beta-catenin-driven HCC

(Submitter supplied) Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. β-catenin has dual cellular functions as a component of the Wnt signaling pathway and adherens junctions. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and downstream activation of Wnt target genes. In patient HCC samples, β-catenin nuclear and cytoplasmic localization are typically patchy, even among HCC with highly active CTNNB1 mutations. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18413
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE137784
ID:
200137784
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